Use of modified pyrimidine compounds to promote stem cell migration and proliferation (CON DIV)

This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells. DIV is for the use of MS-818 to simulate proliferation of retinal stem cells

Use of modified pyrimidine compounds to promote stem cell migration and proliferation (UIC-A)

This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells

Use of modified pyrimidine compounds to promote stem cell migration and proliferation (CON DIV)

This invention provides cells and methods for stimulating proliferation and migration of endogenous and exogenous mammalian stem cells in vivo and in vitro. The invention provides reagents and methods for efficiently proliferating mammalian stem cells in an animal in need thereof and producing stem cells that can be re-introduced into an animal in need thereof to alleviate neurological and corporal disorders

Visually-Aware Context Modeling for News Image Captioning

The goal of News Image Captioning is to generate an image caption according to the content of both a news article and an image. To leverage the visual information effectively, it is important to exploit the connection between the context in the articles/captions and the images. Psychological studies indicate that human faces in images draw higher attention priorities. On top of that, humans often play a central role in news stories, as also proven by the face-name co-occurrence pattern we discover in existing News Image Captioning datasets. Therefore, we design a face-naming module for faces in images and names in captions/articles to learn a better name embedding. Apart from names, which can be directly linked to an image area (faces), news image captions mostly contain context information that can only be found in the article. Humans typically address this by searching for relevant information from the article based on the image. To emulate this thought process, we design a retrieval strategy using CLIP to retrieve sentences that are semantically close to the image. We conduct extensive experiments to demonstrate the efficacy of our framework. Without using additional paired data, we establish the new state-of-the-art performance on two News Image Captioning datasets, exceeding the previous state-of-the-art by 5 CIDEr points. We will release code upon acceptance

Evidence of the Coulomb gap in the density of states of MoS2_2

$\mathrm{MoS_2}$ is an emergent van der Waals material that shows promising prospects in semiconductor industry and optoelectronic applications. However, its electronic properties are not yet fully understood. In particular, the nature of the insulating state at low carrier density deserves further investigation, as it is important for fundamental research and applications. In this study, we investigate the insulating state of a dual-gated exfoliated bilayer $\mathrm{MoS_2}$ field-effect transistor by performing magnetotransport experiments. We observe positive and non-saturating magnetoresistance, in a regime where only one band contributes to electron transport. At low electron density ($\sim 1.4\times 10^{12}~\mathrm{cm^{-2}}$) and a perpendicular magnetic field of 7 Tesla, the resistance exceeds by more than one order of magnitude the zero field resistance and exponentially drops with increasing temperature. We attribute this observation to strong electron localization. Both temperature and magnetic field dependence can, at least qualitatively, be described by the Efros-Shklovskii law, predicting the formation of a Coulomb gap in the density of states due to Coulomb interactions. However, the localization length obtained from fitting the temperature dependence exceeds by more than one order of magnitude the one obtained from the magnetic field dependence. We attribute this discrepancy to the presence of a nearby metallic gate, which provides electrostatic screening and thus reduces long-range Coulomb interactions. The result of our study suggests that the insulating state of $\mathrm{MoS_2}$ originates from a combination of disorder-driven electron localization and Coulomb interactions.Comment: Data repository: https://doi.org/10.3929/ethz-b-00059215

Mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof

This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells

Mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof

This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells

Genetically engineered human mesenchymal stem cells produce met-enkephalin at augmented higher levels in vitro

We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain. However, the usefulness of this procedure is minimal because the availability of human adrenal tissue is very limited. Alternative xenogeneic materials, such as porcine and bovine adrenal chromaffin cells present problems of immune rejection and possible pathogenic contamination. In an attempt to develop opioid peptide-producing cells of autologous origin, we have transfected human mesenchymal stem cells (hMeSCs) with a mammalian expression vector containing a fusion gene of green fluorescent protein (GFP) and human preprocrikephalin (hPPE), a precursor protein for enkephalin opioid peptides. Enkephalins are major neurotransmitters that play an important role in analgesia by activating peripheral opioid receptors. Following the establishment of stable transfection of hMeSCs, the expressions of hPPE and GFP were confirmed and the production of methionine enkephalin (Met-enkephalin) was significantly increased compared to control naive hMeSCs (p \u3c 0.05). Our in vitro data demonstrated that genetically engineered hMeSCs with transfected hPPE gene can constitutively produce opioid peptide Met-enkephalin at an augmented high level. hMeSCs are relatively easy to isolate from a patient\u27s bone marrow aspirates and expand in culture by repeated passages. Autologous hMeSCs would not require immunosuppression when transplanted back into the same patient. Through targeted gene manipulation such as hPPE gene transfection, this may offer a virtually unlimited safe cell supply for the treatment of opioid-sensitive pain in humans

​INTERPLAY BETWEEN SUPERCONDUCTIVITY AND FERROMAGNETISM IN A VAN DER WAALS SUPERCONDUCTOR

Ph.DDOCTOR OF PHILOSOPHY (NUSGS

Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof

This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such that the cells properly migrate and differentiate and a neurological or corporal deficit is improved or remedied as a result