Interplay between the Indonesian Throughflow and the Luzon Strait Throughflow

Author Posting. © Science in China Press and Springer, 2006. This is the author's version of the work. It is posted here by permission of Science in China Press and Springer for personal use, not for redistribution. The definitive version was published in Chinese Science Bulletin 51, Supple. 2 (2006): 50-58.Analysis based on the “Island Rule” and ocean assimilation dataset shows that the interannual variability of the Indonesian Throughflow and the Luzon Strait (South China Sea) Throughflow is out of phase. Wind anomaly in the equatorial Pacific plays an important role in setting up this phase relation. During El Niño events, the westerly wind bursts intensify the Northern Equator Current and induce a northward shift of its bifurcation point. As a result, the partition of volume transport between the Kuroshio and the Mindanao Current is changed, with the Kuroshio transport decreased and the Mindanao Current increased. The undershooting/overshooting phenomena occur at the Luzon Strait and the Sulawesi-Mindanao passage, caused by variability of these two currents. Water transport from the Pacific to the South China Sea increases with the Kuroshio transport decreased, and transport from the Pacific to the Indian Ocean decreases with the Mindanao Current transport increased. Therefore, the interannual variability of the Indonesian Throughflow and the Luzon Strait Throughflow is out of phase.This work was supported by the National Natural Science Foundation of China (Grant No: 40136010, 40520140074)

Organic Molecules in Low-Mass Protostellar Hot Cores: Submillimeter Imaging of IRAS 16293-2422

Arcsecond-resolution spectral observations toward the protobinary system IRAS 16293-2422 at 344 and 354 GHz were conducted using the Submillimeter Array. Complex organic molecules such as CH3OH and HCOOCH3 were detected. Together with the rich organic inventory revealed, it clearly indicates the existence of two, rather than one, compact hot molecular cores (smaller than or equal to 400 AU in radius) associated with each of the protobinary components identified by their dust continuum emission in the inner star-forming core.Comment: 11 pages, 3 figures, to be published in ApJ

Self-Assembled Amphiphilic Chitosan Nanomicelles: Synthesis, Characterization and Antibacterial Activity

Although amphiphilic chitosan has been widely studied as a drug carrier for drug delivery, fewer studies have been conducted on the antimicrobial activity of amphiphilic chitosan. In this study, we successfully synthesized deoxycholic acid-modified chitosan (CS-DA) by grafting deoxycholic acid (DA) onto chitosan C2-NH2, followed by grafting succinic anhydride, to prepare a novel amphiphilic chitosan (CS-DA-SA). The substitution degree was 23.93% for deoxycholic acid and 29.25% for succinic anhydride. Both CS-DA and CS-DA-SA showed good blood compatibility. Notably, the synthesized CS-DA-SA can self-assemble to form nanomicelles at low concentrations in an aqueous environment. The results of CS, CS-DA, and CS-DA-SA against Escherichia coli and Staphylococcus aureus showed that CS-DA and CS-DA-SA exhibited stronger antimicrobial effects than CS. CS-DA-SA may exert its antimicrobial effect by disrupting cell membranes or forming a membrane on the cell surface. Overall, the novel CS-DA-SA biomaterials have a promising future in antibacterial therapy

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

BACKGROUND: Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts as a key downstream target of both peroxisome proliferator-activated receptor α and γ, the agonists of which have been used for lipid lowering and insulin sensitization, respectively. However, the role of FGF21 in the cardiovascular system remains elusive. METHODS AND RESULTS: The roles of FGF21 in atherosclerosis were investigated by evaluating the impact of FGF21 deficiency and replenishment with recombinant FGF21 in apolipoprotein E(-/-) mice. FGF21 deficiency causes a marked exacerbation of atherosclerotic plaque formation and premature death in apolipoprotein E(-/-) mice, which is accompanied by hypoadiponectinemia and severe hypercholesterolemia. Replenishment of FGF21 protects against atherosclerosis in apolipoprotein E(-/-)mice via 2 independent mechanisms, inducing the adipocyte production of adiponectin, which in turn acts on the blood vessels to inhibit neointima formation and macrophage inflammation, and suppressing the hepatic expression of the transcription factor sterol regulatory element-binding protein-2, thereby leading to reduced cholesterol synthesis and attenuation of hypercholesterolemia. Chronic treatment with adiponectin partially reverses atherosclerosis without obvious effects on hypercholesterolemia in FGF21-deficient apolipoprotein E(-/-) mice. By contrast, the cholesterol-lowering effects of FGF21 are abrogated by hepatic expression of sterol regulatory element-binding protein-2. CONCLUSIONS: FGF21 protects against atherosclerosis via fine tuning the multiorgan crosstalk among liver, adipose tissue, and blood vessels.link_to_OA_fulltex