85 research outputs found
Neural Volumetric Mesh Generator
Deep generative models have shown success in generating 3D shapes with
different representations. In this work, we propose Neural Volumetric Mesh
Generator(NVMG) which can generate novel and high-quality volumetric meshes.
Unlike the previous 3D generative model for point cloud, voxel, and implicit
surface, the volumetric mesh representation is a ready-to-use representation in
industry with details on both the surface and interior. Generating this such
highly-structured data thus brings a significant challenge. We first propose a
diffusion-based generative model to tackle this problem by generating voxelized
shapes with close-to-reality outlines and structures. We can simply obtain a
tetrahedral mesh as a template with the voxelized shape. Further, we use a
voxel-conditional neural network to predict the smooth implicit surface
conditioned on the voxels, and progressively project the tetrahedral mesh to
the predicted surface under regularizations. The regularization terms are
carefully designed so that they can (1) get rid of the defects like flipping
and high distortion; (2) force the regularity of the interior and surface
structure during the deformation procedure for a high-quality final mesh. As
shown in the experiments, our pipeline can generate high-quality artifact-free
volumetric and surface meshes from random noise or a reference image without
any post-processing. Compared with the state-of-the-art voxel-to-mesh
deformation method, we show more robustness and better performance when taking
generated voxels as input
IP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury
Patients with occupational medicamentose-like dermatitis due to trichloroethylene often suffer from immune kidney injury. Our previous study reveals that C5b-9-dependent cytosolic Ca2+ overload-induced ferroptosis is involved in trichloroethylene sensitized kidney injury. However, how C5b-9 causes cytosolic Ca2+ rise and the specific mechanism whereby overloaded Ca2+ induces ferroptosis remain unknown. The purpose of our study was to explore the role of IP3R-dependent mitochondrial dysfunction in C5b-9 mediated ferroptosis in trichloroethylene sensitized kidney. Our results showed that IP3R was activated, and mitochondrial membrane potential was decreased in the renal epithelial cells of trichloroethylene-sensitized mice, and these changes were antagonized by CD59, a C5b-9 inhibitory protein. Moreover, this phenomenon was reproduced in a C5b-9-attacked HK-2 cell model. Further investigation showed that RNA interference with IP3R not only alleviated C5b-9-induced cytosolic Ca2+ overload and mitochondrial membrane potential loss but also attenuated C5b-9-induced ferroptosis in HK-2 cells. Mechanistically, IP3R-dependent cytosolic Ca2+ overload activated the mitochondrial permeability transition pore, resulting in the loss of mitochondrial membrane potential and ferroptosis of HK-2 cells. Finally, cyclosporin A, a mitochondrial permeability transition pore inhibitor, not only ameliorated IP3R-dependent mitochondrial dysfunction but also blocked C5b-9-induced ferroptosis. Taken together, these results suggest that IP3R-dependent mitochondrial dysfunction plays an important role in trichloroethylene sensitized renal tubular ferroptosis
Does the built environment make a difference? An investigation of household vehicle use in Zhongshan Metropolitan Area, China
To address worsening urban traffic and environmental issues, planners and policy makers in China have begun to recognize the importance of shaping vehicle use through the built environment. However, very few studies can be found that examine the relationship between the built environment and vehicle u
A Survey of Air-to-Ground Propagation Channel Modeling for Unmanned Aerial Vehicles
In recent years, there has been a dramatic increase in the use of unmanned
aerial vehicles (UAVs), particularly for small UAVs, due to their affordable
prices, ease of availability, and ease of operability. Existing and future
applications of UAVs include remote surveillance and monitoring, relief
operations, package delivery, and communication backhaul infrastructure.
Additionally, UAVs are envisioned as an important component of 5G wireless
technology and beyond. The unique application scenarios for UAVs necessitate
accurate air-to-ground (AG) propagation channel models for designing and
evaluating UAV communication links for control/non-payload as well as payload
data transmissions. These AG propagation models have not been investigated in
detail when compared to terrestrial propagation models. In this paper, a
comprehensive survey is provided on available AG channel measurement campaigns,
large and small scale fading channel models, their limitations, and future
research directions for UAV communication scenarios
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