Geochemical characteristics of dissolved heavy metals in Zhujiang River, Southwest China: spatial-temporal distribution, source, export flux estimation, and a water quality assessment

To investigate the sources and spatial-temporal distribution of dissolved heavy metals in river water, and to evaluate the water quality, a total of 162 water samples were collected from 81 key sampling points in high and low flow seasons separately in the Zhujiang River, Southwest China. Ten dissolved heavy metals (V, Cr, Mn, Co, Ni, Cu, Mo, Cd, Ba, and Pb) in the Zhujiang River water exhibit little variation at temporal scale, but vary with a significant spatial heterogeneity. Furthermore, different metals present different variation trends along the main channel of the Zhujiang River. Our results suggest that Ba (14.72 μg L−1 in low flow season and 12.50 μg L−1 in high flow season) and Cr (6.85 μg L−1 in low flow season and 7.52 μg L−1 in high flow season) are consistently the most abundant metals in the two sampling periods. According to the water quality index (WQI values ranged from 1.3 to 43.9) and health risk assessment, metals investigated in Zhujiang River are below the hazard level (all hazard index (HI) < 1). Application of statistical approaches, including correlation matrix and principal component analysis (PCA), identify three principal components that account for 61.74% of the total variance, the results conclude that the anthropogenic heavy metals (V, Cr, Ni, and Cu) are greatly impacted by the dilution effect, and the heavy metals in Zhujiang River are mainly presented a natural sources signature from the perspective of entire basin. Moreover, our results reveal that the estimated export budget of several heavy metals including V (735.6 t year−1), Cr (1,561.1 t year−1), Ni (498.2 t year−1), and Mo (118.9 t year−1) to the ocean are higher than the world average

Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell.

Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration (IVDD). However, the increased levels of reactive oxygen species (ROS) in the degenerated region will impede the efficiency of human adipose-derived stem cells (human ADSCs) transplantation therapy. It inhibits human ADSCs proliferation, and increases human ADSCs apoptosis. Herein, we firstly devised a novel amphiphilic copolymer PEG-PAPO, which could self-assemble into a nanosized micelle and load lipophilic kartogenin (KGN), as a single complex (PAKM). It was an injectable esterase-responsive micelle, and showed controlled release ability of KGN and apocynin (APO). Oxidative stimulation promoted the esterase activity in human ADSCs, which accelerate degradation of esterase-responsive micelle. Compared its monomer, the PAKM micelle possessed better bioactivities, which were attributed to their synergistic effect. It enhanced the viability, autophagic activation (P62, LC3 II), ECM-related transcription factor (SOX9), and ECM (Collagen II, Aggrecan) maintenance in human ADSCs. Furthermore, it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in rats. Therefore, PAKM micelles perform promoting cell survival and differentiation effects, and may be a potential therapeutic agent for IVDD

The competition and equilibrium in power markets under decarbonization and decentralization

Equilibrium analysis has been widely studied as an effective tool to model gaming interactions and predict market results. However, as competition modes are fundamentally changed by the decarbonization and decentralization of power systems, analysis techniques must evolve. This article comprehensively reviews recent developments in modelling methods, practical settings and solution techniques in equilibrium analysis. Firstly, we review equilibrium in the evolving wholesale power markets which feature new entrants, novel trading products and multi-stage clearing. Secondly, the competition modes in the emerging distribution market and distributed resource aggregation are reviewed, and we compare peer-to-peer clearing, cooperative games and Stackelberg games. Furthermore, we summarize the methods to treat various information acquisition degrees, risk preferences and rationalities of market participants. To deal with increasingly complex market settings, this review also covers refined analytical techniques and agent-based models used to compute the equilibrium. Finally, based on this review, this paper summarizes key issues in the gaming and equilibrium analysis in power markets under decarbonization and decentralization

Response of soil–water characteristics to pore structure of granite residual soils

Granite residual soil is a special regional soil with special mineral composition and pore structure characteristics, which is easy to induce serious geological disasters or engineering problems, so it is particularly important to study its mechanical properties of unsaturated soil and its control mechanism. However, the effects of dry density and initial water content on soil–water characteristic curve (SWCC) and their mechanisms are still unclear. Therefore, samples with different dry densities (1.30 g/cm3, 1.50 g/cm3, 1.70 g/cm3) and initial water content (14 %, 20 %, 22 %) were set up in this paper. SWCC test was conducted on the two groups of samples under the humidification path and dehumidification path using filter paper method. Combined with scanning electron microscopy (SEM) test and pore-size distribution (PSD) test, the influence mechanism of different micro-pore structure on SWCC and hysteresis characteristics of granite residual soil was analyzed qualitatively and quantitatively. The results show that the samples with different dry densities basically coincide with each other in the high suction segment. The larger the dry density is, the smaller the range of transition zone in the low suction segment is. As the initial water content of the sample increases from 14 % to 22 %, SWCC changes from a single increase curve to a double increase curve, and the corresponding pore-size distribution curve (PSDC) changes from a trimodal curve to a bimodal curve. The SWCC of granite residual soil has obvious hysteresis effect, and the hysteresis area becomes smaller with the increase of dry density. The inflection point exists in the hysteresis area of SWCCS with higher initial water content. The distribution range of macropore is determined by dry density, and the distribution range of small pore is determined by initial water content. The transformation of SWCC from a single increase curve to a double increase curve is mainly controlled by the distribution range of small pores. The bottleneck effect in the migration process of pore water in the soil and the pore redistribution during water intake and water loss are the main reason for the hysteresis of SWCC. The results of this work provide some guidance for the study of unsaturated soil mechanical properties of granite residual soils

Heavy Metals in Suspended Particulate Matter of the Zhujiang River, Southwest China: Contents, Sources, and Health Risks

To investigate the abundance, water/particle interaction behavior, sources, and potential risk of heavy metals in suspended particulate matter (SPM), a total of 22 SPM samples were collected from the Zhujiang River, Southwest China, in July 2014 (wet season). Nine heavy metal(loid)s (V, Cr, Mn, Ni, Cu, Zn, As, Cd and Pb) in SPM were detected. The results show that the selected heavy metal(loid)s in SPM appear in the following order: Mn (982.4 mg kg(-1)) > Zn (186.8 mg kg(-1)) > V (143.6 mg kg(-1)) > Cr (129.1 mg kg(-1)) > As (116.8 mg kg(-1)) > Cu (44.1 mg kg(-1)) > Ni (39.9 mg kg(-1)) > Pb (38.1 mg kg(-1)) > Cd (3.8 mg kg(-1)). Furthermore, both the enrichment factor (EF) and geo-accumulation index (I-geo) indicate that SPM is extremely enriched in metal(loid)s of Cd and As, while SPM is slightly enriched, or not enriched, in other heavy metals. According to the toxic risk index (TRI) and hazard index (HI), arsenic accounts for the majority of the SPM toxicity (TRI = 8, 48.3 +/- 10.4%) and causes the primary health risk (HI > 1), and the potential risks of V and Cr are also not negligible. By applying a correlation matrix and principal component analysis (PCA), three principal components (PC) were identified and accounted for 79.19% of the total variance. PC 1 (V, Cr, Mn, Ni, Cu, and Pb) is controlled by natural origins. PC 2 (As and Cd) is mainly contributed by anthropogenic origins in the basin. PC 3 (Zn) can be attributed to mixed sources of natural and anthropogenic origins. Moreover, all the partition coefficients (lgK(d)) exceeded 2.9 (arithmetical mean value order: Mn > Pb > Cd > V approximate to Cu > Cr approximate to Ni), indicating the powerful adsorptive ability of SPM for these heavy metal(loid)s during water/particle interaction

Optimum Design for Inserted Tooth Slips Setting Process Based on the Furrow Effect

This work established a finite element analysis (FEA) model of an inserted tooth-type slip assembly under bear setting load and axial load, calculated the differences between the inserted teeth of the sidetracking packer slip-formed furrow shapes on the casing face, and analyzed the setting reliability of the inserted tooth slip sidetracking packer. The orthogonal optimization analysis of the structural parameters of the sidetracking packer was carried out on the basis of the furrow effect. Finally, the setting experiment was conducted with the inserted tooth slip sidetracking packer developed to verify correctness of the FEA model and the simulation results. The results show that in the FEA and calculation of the setting process of the inserted tooth-type slip, it is not only necessary to consider the furrow friction coefficient, but also the effect of the ridge on the furrow friction coefficient. The corresponding furrow friction coefficient varies according to the different furrow effects occurring on the casing surface caused by the various types of teeth inserted on the packer slips. The furrow effect is related to the sharpness of the tooth tips of the slips. The sharper the tooth tips, the more obvious the furrow effect is. Under the dual effects of the furrow effect and the adhesion effect, the carbide teeth of the slip feed into the casing wall to produce a uniform and distinct indentation on the premise of meeting the inserted tooth strength to ensure a reliable setting and hanging the inserted tooth slip sidetracking packer. The optimal combination of slip parameters was obtained by taking the optimal bite depth uniformity as the objective function: slip tooth installation spacing L = 10 mm, slip tooth installation angle α = 80°, slip tooth diameter d = 10 mm, and slip wedge angle β = 6°. The standard deviation of bite depth uniformity of the optimized slip teeth is 74.45% lower than that before optimization. The research results of this paper basically meet the requirements of engineering applications