961 research outputs found
Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases
Neutrophils are one of the first immune cell types that are recruited to injury and infection site. As a vital component of the immune system, neutrophils are heterogeneous immune cells known to have phagocytic property and function in inflammation. Recent studies revealed that neutrophils play dual roles in tumor initiation, development, and progression. The multifunctional roles of neutrophils in diseases are mainly due to their production of different effector molecules under different conditions. N1 and N2 neutrophils or high density neutrophils (HDNs) and low density neutrophils (LDNs) have been used to distinguish neutrophils subpopulations with pro- vs. anti-tumor activity, respectively. Indeed, N1 and N2 neutrophils also represent immunostimulating and immunosuppressive subsets, respectively, in cancer. The emerging studies support their multifaceted roles in autoimmune diseases. Although such subsets are rarely identified in autoimmune diseases, some unique subsets of neutrophils, including low density granulocytes (LDGs) and CD177+ neutrophils, have been reported. Given the heterogeneity and functional plasticity of neutrophils, it is necessary to understand the phenotypical and functional features of neutrophils in disease status. In this article, we review the multifaceted activates of neutrophils in cancer and autoimmune diseases, which may support new classification of neutrophils to help understand their important functions in immune homeostasis and pathologies
Bis(1-methyl-1-phenylethyl) peroxide
In the crystal structure, the title compound (also called dicumyl peroxide), C18H22O2, lies on a center of symmetry. The COOC plane including the dioxy group makes a dihedral angle of 79.10 (5)° with the phenyl ring. An intermolecular C—H⋯π interaction is observed between the phenyl groups
Imidazolium 3-nitrobenzoate
In the title compound, C3H5N2
+·C7H4NO4
−, the benzene ring forms a dihedral angle of 40.60 (5)° with the imidizolium ring. The nitrobenzoate anion is approximately planar: the benzene ring makes dihedral angles of 3.8 (3) and 3.2 (1)° with the nitro and carboxylate groups, respectively. In the crystal structure, the cations and anions are linked by intermolecular N—H⋯O hydrogen bonds, forming a zigzag chain along the b axis
Reproducibility and relative validity of a semi-quantitative food frequency questionnaire for Chinese pregnant women
On-chip black hole: Hawking radiation and curved spacetime in a superconducting quantum circuit with tunable couplers
Hawking radiation is one of quantum features of a black hole, which can be
understood as a quantum tunneling across the event horizon of the black hole,
but it is quite difficult to directly observe the Hawking radiation of an
astrophysical black hole. Remarkable experiments of analogue black holes on
various platforms have been performed. However, Hawking radiation and its
quantum nature such as entanglement have not been well tested due to the
experimental challenges in accurately constructing curved spacetime and
precisely measuring the thermal spectrum. Based on the recent architecture
breakthrough of tunable couplers for superconducting processor, we realize
experimentally an analogue black hole using our new developed chip with a chain
of 10 superconducting transmon qubits with interactions mediated by 9
transmon-type tunable couplers. By developing efficient techniques to engineer
the couplings between qubits via tuning couplers, we realize both the flat and
curved spacetime backgrounds. The quantum walks of quasi-particle in the curved
spacetime reflect the gravitational effect around the black hole, resulting in
the behavior of Hawking radiation. By virtue of the state tomography
measurement of all 7 qubits outside the analogue event horizon, we show that
Hawking radiation can be verified. In addition, an entangled pair is prepared
inside the horizon and the dynamics of entanglement in the curved spacetime is
directly measured. Our results would stimulate more interests to explore
information paradox, entropy and other related features of black holes using
programmable superconducting processor with tunable couplers.Comment: modified manuscripts, 7 pages, 4 figures (main text) + 12 pages
(supplementary information
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