Drug-coated balloon treatment in coronary artery disease: Recommendations from an Asia-Pacific Consensus Group

Coronary artery disease (CAD) is currently the leading cause of death globally, and the prevalence of thisdisease is growing more rapidly in the Asia-Pacific region than in Western countries. Although the useof metal coronary stents has rapidly increased thanks to the advancement of safety and efficacy of newergeneration drug eluting stent (DES), patients are still negatively affected by some the inherent limitationsof this type of treatment, such as stent thrombosis or restenosis, including neoatherosclerosis, andthe obligatory use of dual antiplatelet therapy (DAPT) with unknown optimal duration.Drug-coated balloon (DCB) treatment is based on a leave-nothing-behind concept and therefore it is notlimited by stent thrombosis and long-term DAPT; it directly delivers an anti-proliferative drug whichis coated on a balloon after improving coronary blood flow. At present, DCB treatment is recommendedas the first-line treatment option in metal stent-related restenosis linked to DES and bare metal stent.For de novo coronary lesions, the application of DCB treatment is extended further, for conditions suchas small vessel disease, bifurcation lesions, and chronic total occlusion lesions, and others. Recently,several reports have suggested that fractional flow reserve guided DCB application was safe for largercoronary artery lesions and showed good long-term outcomes. Therefore, the aim of these recommendationsof the consensus group was to provide adequate guidelines for patients with CAD based on objectiveevidence, and to extend the application of DCB to a wider variety of coronary diseases and guide theirmost effective and correct use in actual clinical practice

Identification of a wetland ecological network for urban heat island effect mitigation in Changchun, China

The rapid development of cities has led to severe fragmentation of wetland landscapes, destroying their ecological function in climate regulation. However, most studies on the climate regulation services of wetlands focused on isolated wetland units, ignoring the overall function of wetland networks. The climate regulation function of wetlands can be improved by integrating fragmented wetland resources and building a stable wetland network. A case study was carried out in Changchun City, China, to improve the method of identifying ecological networks by considering the network energy flows. First, morphological spatial pattern analysis and landscape connectivity index combined with the wetland cooling index were used to identify ecological sources with high cooling capacity, and an ecological resistance surface was constructed with surface temperature as the main factor. The minimum cumulative resistance model was then used to identify the ecological network, which was then optimized by integrating patches as stepping stones to form the optimized ecological network. Finally, the importance of ecological corridors was evaluated by identifying ventilation corridors and integrated with the complex network theory to determine the ecological network robustness. We found that the degree of fragmentation in the studied wetlands was relatively high, and that construction of an ecological network with patches as stepping stones can improve its robustness. Each component in the ecological network had a high potential to mitigate the urban heat island effect, which can be further promoted by ecological corridors with high ventilation potential. Mutations in ecological nodes that cause network robustness played a key role in maintaining ecological network stability. This improved methodology effectively improves the scientific and practical application of wetland networks to mitigate the urban heat island effect and provides regions facing the contradiction of rapid development and wetland protection with strategies to reduce the threat of this effect

Cenozoic tectonic evolution and dynamics of Turkana Depression, East African Rift

As a typical continental rift at the embryonic stage of the Wilson cycle, the East African Rift System (EARS) is a natural place for studying plate tectonic kinematics and dynamics. The Turkana area of the EARS is of special interest science, which has been influenced by pre-existing fabrics and Mesozoic rift activities. The evolution of EARS has important significance for understanding and perfecting the evolution process of continental rifts. Based on the collected low-temperature thermochronometer study results, drilling and field outcrop data, combined with seismic data, through comprehensive analysis of rift activity time and fault activity rate analysis, this study redefined the rift evolution sequence in Turkana area, and the Cenozoic rift activity in the study area can be divided into four stages of evolution. The characteristics of the evolution of the study area are summarized as follows: early stage rift began in the south and later stage in the north, first wide rift and later narrow rift, moving to the eastward. The rift evolution is generally controlled by the combined action of pre-existing fabrics and mantle plume activity. The migration of mantle activities not only affects the migration of volcanoes and rift activities, but also may change the development pattern