Comparison of Cisplatin and Nitrogen Mustard Derivatives in Cancer Treatment

Platinum-containing complexes and nitrogen mustard derivatives are two drug families for cancer treatment. The two core drugs of the families were Cisplatin, created in 1845, and Chlormethine (mustine), created in 1925. Cisplatin is used to treat cancers like ovarian, breast, lung, esophageal, and many more. Nitrogen mustards are used as palliative care in lung and breast cancers as well as treatment for Hodgkin’s disease. The two families of drugs in treating cancer will be compared in terms of mechanism, side effects, and resistance factors. The report will also focus on the importance of the Pt metal in cancer treatment

Comparison of Cisplatin and Nitrogen Mustard Derivatives in Cancer Treatment

Platinum-containing complexes and nitrogen mustard derivatives are two drug families for cancer treatment. The two core drugs of the families were Cisplatin, created in 1845, and Chlormethine (mustine), created in 1925. Cisplatin is used to treat cancers like ovarian, breast, lung, esophageal, and many more. Nitrogen mustards are used as palliative care in lung and breast cancers as well as treatment for Hodgkin’s disease. The two families of drugs in treating cancer will be compared in terms of mechanism, side effects, and resistance factors. The report will also focus on the importance of the Pt metal in cancer treatment

Energy-Water-Carbon Nexus Optimization for the Path of Achieving Carbon Emission Peak in China Considering Multiple Uncertainties: A Case Study in Inner Mongolia

The Chinese government has launched a guideline for carbon emissions up to the peak (CEUP) in the 2030 target. The electric power sector has to make its own contributions to the national CO2 emissions mitigation target. In this study, a patron–client interactive optimized (PCIO) model is proposed to investigate the regional energy–water–carbon nexus optimization under the policy background of the CEUP target. Inner Mongolia, the largest energy base in China, which is also facing the prominent contradiction including the energy production and serious environmental problems, is chosen as a case study. Multiple uncertainties, including the fuel price uncertainty and output of the wind and solar power, are considered to make the optimization process more realistic. Results show that coal-fired power will gradually be substituted by the gas, wind, and solar power in Inner Mongolia to reach the CEUP target. The CO2 capture and storage technology and air-cooling systems will play important roles, especially under the strict water policy scenario. However, the achievement of the CEUP and water-saving target will be at the expense of high system costs. The PCIO model makes it possible for the decision-maker to make flexible strategies to balance the CEUP target and saving system costs. The results have demonstrated the validity of the PCIO model in addressing the hierarchical programming problems

A Comparison of Two Supplementary Doses of Vitamin A on Performance, Intestine and Immune Organ Development, as well as Gene Expression of Inflammatory Factors in Young Hy-Line Brown Laying Pullets

The objective of this study was to compare two supplementary doses (6000 vs. 12,000 IU/kg) of vitamin A (VA) on the performance, development of intestine and immune organs, as well as gene expression of inflammatory factors in young Hy-Line Brown laying pullets. A total of 288 one-day-old Hy-Line Brown laying pullets (weighing 42.15 ± 0.23 g) were allotted into two treatments with 12 replicate cages and 12 birds per cage. During the 35-day period, the pullets were fed a basal diet supplemented with different doses of VA (6000 IU/kg VA in control group; 12,000 IU/kg VA in treatment group), respectively. The results showed that supplementary high doses of VA reduced the feed-to-gain ratio from day 21 to 35 (p < 0.05). Moreover, the pullets fed high doses of VA diets had increased length and relative weight of duodenum, jejunum, and ileum (p < 0.05). From observations on morphology, high doses of VA diets increased the villus height and the ratio of villus height to crypt depth in the jejunum and ileum (p < 0.05). High doses of VA diets also increased the relative weight of immune organs (p < 0.05). Furthermore, the gene expressions of inflammatory factors were decreased in the thymus of the pullets fed high doses of VA diets (p < 0.05). In summary, supplementary 12,000 IU/kg doses of VA improved performance and intestine and immune organ development, and alleviated gene expressions of inflammatory factors in young Hy-Line Brown laying pullets

Nationalism, conspiracy theories and vaccine mandates: Exploring the statism determinants for attitudes to COVID-19 control in China

Introduction: China’s loosening its COVID-19 controls highlighted its insufficiency in vaccination protection. Mandatory vaccination might be necessary if the gap cannot be filled over a short time. However, few studies have explored how Chinese people view the COVID-19 vaccine mandates, let alone placing such views in the country’s highly politicized context. Material and methods: The current study utilizes data from a national survey adopting quota sampling to analyze the Chinese public's medical and non-medical considerations when judging compulsory COVID-19 vaccination (n = 1,523). The survey was conducted between 1 and 8 April 2021. All adults aged 18 years and older were eligible to take part. The survey included sociodemographic details, perceived susceptibility to infection, perceived vaccine benefit, attitudes to vaccination policies, nationalism, beliefs in various conspiracy theories and science literacy. Multiple regression analyses were done to examine factors associated with the attitude to COVID-19 vaccine mandates. Results: The study reveals that personal risk and benefit perceptions did not dominate the Chinese public’s attitude toward vaccination mandates. Instead, nationalism was relatively strongly associated with their willingness to accept mandatory vaccination. Contrary to studies in the West, various conspiracy beliefs and conspiratorial thinking were robustly related to the support for mandatory vacciniation. Science literacy didn’t link to the attitude to vaccination mandates. It only had a weak moderating effect on the influence of conspiratorial thinking on attitudes to the vaccination policies. Conclusions: The results indicated that Chinese people’s attitude to the COVID-19 vaccination policy is highly politicized and influenced by conspiracy theories. Given the potentially massive impacts of the COVID-19 infection, we need to educate the Chinese public with more medically valuable and relevant information to help them make sound decisions regarding vaccination. Meanwhile, we can adopt nationalistic tones to improve the persuasion effect, but misinformation during the process must be overcome

Policy Endorsement and Booster Shot: Exploring Politicized Determinants for Acceptance of a Third Dose of COVID-19 Vaccine in China

China’s recent termination of strict COVID-19 control necessitates taking a booster vaccine shot as a precaution against the pandemic as quickly as possible. A large body of research has examined people’s attitudes toward and intentions for the booster shot. However, most studies failed to explore how China’s sociopolitical context has shaped their attitude regarding the booster jab take-up. The current study utilizes data from a national survey adopting quota sampling to analyze the Chinese public’s medical and non-medical considerations to determine their intention for the third dose of the COVID-19 vaccine. The study found that thanks to China’s initial successful lockdown policies, personal risk and benefit perceptions did not dominate their views regarding booster vaccination. Instead, respondents’ gender, nationalism, endorsement of the zero-COVID policy, self-efficacy regarding vaccination, and perceived infection severity were the major factors underlying their booster shot intention. The situation highlights how the politicized context of China’s COVID-19 control has impacted people’s plans to practice preventive behaviors. It is necessary to offset the negative consequences. One strategy is to educate the Chinese public with more medically relevant information to help them make rational choices regarding vaccination and other protective measures. On the other hand, such education can utilize this nationalistic mental status to enhance the persuasion effect

Learning Summary-Worthy Visual Representation for Abstractive Summarization in Video

Multimodal abstractive summarization for videos (MAS) requires generating a concise textual summary to describe the highlights of a video according to multimodal resources, in our case, the video content and its transcript. Inspired by the success of the large-scale generative pre-trained language model (GPLM) in generating high-quality textual content (e.g., summary), recent MAS methods have proposed to adapt the GPLM to this task by equipping it with the visual information, which is often obtained through a general-purpose visual feature extractor. However, the generally extracted visual features may overlook some summary-worthy visual information, which impedes model performance. In this work, we propose a novel approach to learning the summary-worthy visual representation that facilitates abstractive summarization. Our method exploits the summary-worthy information from both the cross-modal transcript data and the knowledge that distills from the pseudo summary. Extensive experiments on three public multimodal datasets show that our method outperforms all competing baselines. Furthermore, with the advantages of summary-worthy visual information, our model can have a significant improvement on small datasets or even datasets with limited training data.Comment: Accepted by IJCAI-202