Coping strategies following the diagnosis of a fetal anomaly: A scoping review

IntroductionMany women experience severe emotional distress (such as grief, depression, and anxiety) following a diagnosis of fetal anomaly. The ability to cope with stressful events and regulate emotions across diverse situations may play a primary role in psychological wellbeing. This study aims to present coping strategies after disclosing a fetal anomaly to pregnant women.MethodsThis is a scoping review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews (PRISMA-ScR). Electronic databases, including Web of Science (WOS, BCI, KJD, MEDLINE, RSCI, SCIELO), CINAHL, and EBSCO PsycARTICLES, were used to search for primary studies from the inception of each database to 2021. The keywords were determined by existing literature and included: “fetal anomaly,” “fetal abnormality,” “fetal anomaly,” “fetal abnormality” AND “cope,” “coping,” “deal,” “manage,” “adapt*,” “emotion* regulate*,” with the use of Boolean operators AND/OR. A total of 16 articles were reviewed, followed by advancing scoping review methodology of Arksey and O'Malley's framework.ResultsIn this review, we identified 52 coping strategies using five questionnaires in seven quantitative studies and one mixed-method study. The relationship between coping strategies and mental distress was explored. However, the results were inconsistent and incomparable. We synthesized four coping categories from qualitative studies and presented them in an intersection.ConclusionThis scoping review identified the coping strategies of women with a diagnosis of a fetal anomaly during pregnancy. The relationship between coping strategies and mental distress was uncertain and needs more exploration. We considered an appropriate measurement should be necessary for the research of coping in women diagnosed with fetal anomaly pregnancy

Magneto-elastic internal resonance of an axially moving conductive beam in the magnetic field

The Hamiltonian principle is applied to the nonlinear vibration equation of an axially moving conductive beam in the magnetic field with consideration of the axial velocity, axial tension, electromagnetic coupling effect and complex boundary conditions. Nonlinear vibration characteristics of the free vibrating beam under 1:3 internal resonances are studied based on our approach. For beams with one end fixed and the other simply supported, the nonlinear vibration equation is dispersed by the Galerkin method, and the vibration equations are solved by the multiple-scales method. As a result, the coupled relations between the first-order and second-order vibration modes are obtained in the internal resonance system. Firstly, the influence of initial conditions, axial velocity and the external magnetic field strength on the vibration modes is analysed in detail. Secondly, direct numerical calculation on the vibration equations is carried out in order to evaluate the accuracy of the perturbation approach. It is found that through numerical calculations, in the undamped system, the vibration modes are more sensitive to the initial value of vibration amplitude. The amplitude changes of the first-order and second-order modes resulting from the increase of the initial amplitude value of the vibration modes respectively are very special, and present a “reversal behaviour”. Lastly, in the damped system, the vibration modes exhibit a trend of coupling attenuation with time. Its decay rate increases when the applied magnetic field strength becomes stronger

The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. In recent years, many studies have proposed a possible link between ASD and multiple environmental as well as genetic risk factors; nevertheless, recent studies have still failed to identify the specific pathogenesis. An analysis of the literature showed that oxidative stress and redox imbalance caused by high levels of reactive oxygen species (ROS) are thought to be integral parts of ASD pathophysiology. On the one hand, this review aims to elucidate the communications between oxidative stress, as a risk factor, and ASD. As such, there is also evidence to suggest that early assessment and treatment of antioxidant status are likely to result in improved long-term prognosis by disturbing oxidative stress in the brain to avoid additional irreversible brain damage. Accordingly, we will also discuss the possibility of novel therapies regarding oxidative stress as a target according to recent literature. On the other hand, this review suggests a definite relationship between ASD and an unbalanced gastrointestinal tract (GIT) microbiota (i.e., GIT dysbiosis). A variety of studies have concluded that the intestinal microbiota influences many aspects of human health, including metabolism, the immune and nervous systems, and the mucosal barrier. Additionally, the oxidative stress and GIT dysfunction in autistic children have both been reported to be related to mitochondrial dysfunction. What is the connection between them? Moreover, specific changes in the GIT microbiota are clearly observed in most autistic children, and the related mechanisms and the connection among ASD, the GIT microbiota, and oxidative stress are also discussed, providing a theory and molecular strategies for clinical practice as well as further studies

An Identity-Based Cross-Domain Authenticated Asymmetric Group Key Agreement

Cross-domain authenticated asymmetric group key agreement allows group members in different domains to establish a secure group communication channel and the senders can be anyone. However, the existing schemes do not meet the requirement of batch verification in the group key negotiation phase, which makes the schemes have low efficiency. To address this problem, an identity-based cross-domain authenticated asymmetric group key agreement is proposed that supports batch verification. The performance analysis shows that this protocol is highly efficient. Finally, the proposed protocol is proved to be secure under the k-Bilinear Diffie–Hellman Exponent assumption

A microfluidics-based method for isolation and visualization of cells based on receptor-ligand interactions.

Receptor-ligand binding has been analyzed at the protein level using isothermal titration calorimetry and surface plasmon resonance and at the cellular level using interaction-associated downstream gene induction/suppression. However, no currently available technique can characterize this interaction directly through visualization. In addition, all available assays require a large pool of cells; no assay capable of analyzing receptor-ligand interactions at the single-cell level is publicly available. Here, we describe a new microfluidic chip-based technique for analyzing and visualizing these interactions at the single-cell level. First, a protein is immobilized on a glass slide and a low-flow-rate pump is used to isolate cells that express receptors that bind to the immobilized ligand. Specifically, we demonstrate the efficacy of this technique by immobilizing biotin-conjugated FGL2 on an avidin-coated slide chip and passing a mixture of GFP-labeled wild-type T cells and RFP-labeled FcγRIIB-knockout T cells through the chip. Using automated scanning and counting, we found a large number of GFP+ T cells with binding activity but significantly fewer RFP+ FcγRIIB-knockout T cells. We further isolated T cells expressing a membrane-anchored, tumor-targeted IL-12 based on the receptor's affinity to vimentin to confirm the versatility of our technique. This protocol allows researchers to isolate receptor-expressing cells in about 4 hours for further downstream processing

20k curved output

19685 output curved triangle meshes

20k Input

19686 input feature files (.json) and segment files (.obj)

Exmaples in the paper

Input and output for the examples in the paper

Exmaples in the paper

Input and output for the examples in the paper

20k linear output

19686 output linear triangle meshes using the linear pipeline