Impossible meet-in-the-middle fault analysis on the LED lightweight cipher in VANETs

With the expansion of wireless technology, vehicular ad-hoc networks (VANETs) are emerging as a promising approach for realizing smart cities and addressing many serious traffic problems, such as road safety, convenience, and efficiency. To avoid any possible rancorous attacks, employing lightweight ciphers is most effective for implementing encryption/decryption, message authentication, and digital signatures for the security of the VANETs. Light encryption device (LED) is a lightweight block cipher with two basic keysize variants: LED-64 and LED-128. Since its inception, many fault analysis techniques have focused on provoking faults in the last four rounds to derive the 64-bit and 128-bit secret keys. It is vital to investigate whether injecting faults into a prior round enables breakage of the LED. This study presents a novel impossible meet-in-the-middle fault analysis on a prior round. A detailed analysis of the expected number of faults is used to uniquely determine the secret key. It is based on the propagation of truncated differentials and is surprisingly reminiscent of the computation of the complexity of a rectangle attack. It shows that the impossible meet-in-the-middle fault analysis could successfully break the LED by fault injections

Expression of pathogenesis related genes in response to salicylic acid, methyl jasmonate and 1-aminocyclopropane-1-carboxylic acid in Malus hupehensis (Pamp.) Rehd

<p>Abstract</p> <p>Background</p> <p>Many studies have been done to find out the molecular mechanism of systemic acquired resistance (SAR) in plants in the past several decades. Numbers of researches have been carried out in the model plants such as arabidopsis, tobacco, rice and so on, however, with little work done in woody plants especially in fruit trees such as apple. Components of the pathway of SAR seem to be extremely conserved in the variety of species. <it>Malus hupehensis</it>, which is origin in China, is strong resistance with rootstock. In the study, we attempted to make the expression pattern of pathogenesis related (PR) genes which were downstream components of the SAR pathway in response to salicylic acid(SA), methyl jasmonate(MeJA) and 1-aminocyclopropane-1-carboxylic acid(ACC) in <it>Malus hupehensis</it>.</p> <p>Findings</p> <p>In order to analyze the expression pattern, the partial sequence of three PR genes from <it>Malus hupehensis</it>, <it>MhPR1</it>, <it>MhPR5 </it>and <it>MhPR8 </it>was isolated. These three PR genes were induced by SA, MeJA and ACC. However, <it>MhPR1</it>, <it>MhPR5 </it>and <it>MhPR8 </it>performed a distinct pattern of expression in different plant organs. <it>MhPR5 </it>and <it>MhPR8 </it>were basal expression in leaves, stems and roots, and <it>MhPR1 </it>was basal expression only in stems. The expression of <it>MhPR1</it>, <it>MhPR5 </it>and <it>MhPR8 </it>was enhanced during the first 48 h post-induced with SA, MeJA and ACC.</p> <p>Conclusions</p> <p>The results showed that a distinct pattern of expression of PR genes in <it>Malus hupehensis </it>which differed from the previous reports on model plants arabidopsis, tobacco and rice. <it>MhPR1</it>, <it>MhPR5 </it>and <it>MhPR8 </it>were induced by SA, MeJA and ACC, which were regarded as the marker genes in the SAR response in <it>Malus hupehensis</it>. In contrast with herbal plants, there could be specific signal pathway in response to SA, JA and ET for woody plants.</p

A Novel Index for Impervious Surface Area Mapping: Development and Validation

The distribution and dynamic changes in impervious surface areas (ISAs) are crucial to understanding urbanization and its impact on urban heat islands, earth surface energy balance, hydrological cycles, and biodiversity. Remotely sensed data play an essential role in ISA mapping, and numerous methods have been developed and successfully applied for ISA extraction. However, the heterogeneity of ISA spectra and the high similarity of the spectra between ISA and soil have not been effectively addressed. In this study, we selected data from the US Geological Survey (USGS) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) spectral libraries as samples and used blue and near-infrared bands as characteristic bands based on spectral analysis to propose a novel index, the perpendicular impervious surface index (PISI). Landsat 8 operational land imager data in four provincial capital cities of China (Wuhan, Shenyang, Guangzhou, and Xining) were selected as test data to examine the performance of the proposed PISI in four different environments. Threshold analysis results show that there is a significant positive correlation between PISI and the proportion of ISA, and threshold can be adjusted according to different needs with different accuracy. Furthermore, comparative analyses, which involved separability analysis and extraction precision analysis, were conducted among PISI, biophysical composition index (BCI), and normalized difference built-up index (NDBI). Results indicate that PISI is more accurate and has better separability for ISA and soil as well as ISA and vegetation in the ISA extraction than the BCI and NDBI under different conditions. The accuracy of PISI in the four cities is 94.13%, 96.50%, 89.51%, and 93.46% respectively, while BCI and NDBI showed accuracy of 77.53%, 93.49%, 78.02%, and 84.03% and 58.25%, 57.53%, 77.77%, and 64.83%, respectively. In general, the proposed PISI is a convenient index to extract ISA with higher accuracy and better separability for ISA and soil as well as ISA and vegetation. Meanwhile, as PISI only uses blue and near-infrared bands, it can be used in a wider variety of remote sensing images

Rapamycin attenuates ioversol-induced acute kidney injury in rat models

Objective To investigate the role of autophagy in contrast-induced acute kidney injury (CI-AKI) in rats and to explore its possible mechanism. Methods SD rats were randomly divided into control group, acute kidney injury model group (intravenous injection of contrast medium ioversol via tail vein; model), rapamycin(RAPA) group and hydroxychloroquine (HCQ)group. Blood urea nitrogen(BUN) and serum creatinine(Scr) contents were measured and the potential change foun in renal pathology was detected by HE staining and microscopy. Transmission electron microscopy was used to observe auto-phagy-related changes in ultrastructure.Western blot was used to observe the expression of microtubule-associated protein 1 light chain 3(LC3)Ⅱ/LC3Ⅰ,ubiquitin-binding protein p62 and Histone deacetylase 4(HDAC4). The expression of HDAC4 was also observed by RT-qPCR. Results Compared with control group, the level of BUN, Scr and HDAC4 expression in the model and HCQ group was increased (P＜0.01),the proximal tubules of the kidney were significantly damaged. In the model group, autophagososomes and autolysosomes increased, accompanied by an increase of LC3Ⅱ/LC3Ⅰ and a decrease in the p62 level (P＜0.05,P＜0.01); Compared with model group, there were more autophagosomes and autolysosomes were found in RAPA group(P＜0.01), accompanied by increased LC3Ⅱ/LC3Ⅰ ratio and decrease in the p62 and HDAC4(P＜0.05,P＜0.01). In contrast, the number of autophagy related structures decreased in HCQ group(P＜0.01), accompanied by the simultaneous increase of LC3Ⅱ/LC3Ⅰ, p62 and the increase of HDAC4(P＜0.01). Conclusions Ioversol may induce autophagy activation, while enhancing autophagy by RAPA alleviates CI-AKI induced renal dysfunction. The mechanism is potentially atributed to the regulation of HDAC4

High Methanol Gas-Sensing Performance of Sm2O3/ZnO/SmFeO3 Microspheres Synthesized Via a Hydrothermal Method

Abstract In this work, we synthesized Sm2O3/ZnO/SmFeO3 microspheres by a hydrothermal method combined with microwave assistance to serve as a methanol gas sensor. We investigated the effect on the microstructure at different hydrothermal times (12 h, 18 h, 24 h, and 30 h), and the BET and XPS results revealed that the specific surface area and adsorbed oxygen species were consistent with a microstructure that significantly influences the sensing performance. The gas properties of the Sm2O3-doped ZnO/SmFeO3 microspheres were also investigated. With a hydrothermal time of 24 h, the gas sensor exhibited excellent sensing performance for methanol gas. For 5 ppm of methanol gas at 195 °C, the response reached 119.8 with excellent repeatability and long-term stability in a 30-day test in a relatively high humidity atmosphere (55–75% RH). Even at 1 ppm of methanol gas, the response was also higher than 20. Thus, the Sm2O3-doped ZnO/SmFeO3 microspheres can be considered as prospective materials for methanol gas sensors

Prognostic roles of hematological indicators for the efficacy and prognosis of immune checkpoint inhibitors in patients with advanced tumors: a retrospective cohort study

Abstract Background Immunocheckpoint inhibitor(ICI) is a major breakthrough in tumor treatment. It can activate the patient’s own immune system and play an anti-tumor role, but not all patients can benefit from it. At present, there is still a lack of effective biomarkers to guide clinical application. The systemic immune inflammation(SII) index reflects the systemic inflammatory state and immune state of patients. Prognostic nutrition index(PNI) can be used to evaluate immune status of patients. Therefore, SII and PNI indexes may have some value in predicting the efficacy and prognosis of immunotherapy, but there is still a lack of relevant research. The purpose of our study was to explore the influence of SII and PNI index on the efficacy and prognosis of immunotherapy. Methods A total of 1935 patients treated with ICIs treatment in the Fourth Hospital of Hebei Medical University from November 2016 to October 2021 were retrospectively collected. 435 patients who met the inclusion criteria and did not meet the exclusion criteria. The imaging data, blood results of each patient were collected within 1 week before ICIs treatment. The neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR), monocyte lymphocyte ratio(MLR), PNI,systemic inflammatory response index(SIRI),neutrophil-eosinophil ratio(NER) was calculated. The patients were followed up by in-patient, out-patient reexamination and telephone contact, and the efficacy evaluation and survival status were recorded. The deadline of follow-up: January 2021. SPSS-24.0 software was employed for statistical analysis. Results Among the 435 patients receiving ICI treatment, 61,236 and 138 patients were evaluated respectively as partial response (PR), stable disease (SD) and progressive disease (PD). The overall response rate(ORR) and disease control rate (DCR) of this cohort were 14.0% and 68.3%, respectively. Median progression-free survival (mPFS) is 4.0 months, The overall survival (mOS) of this cohort is 6.8 months. Multivariate analysis showed that SIRI(Hazard Ratio, HR = 1.304, P = 0.014), PNI (HR = 0.771, P = 0.019), prealbumin (PAB) (HR = 0.596, P = 0.001), and PNI(HR = 0.657, P = 0.008) were independent risk factors for PFS and OS, respectively. Conclusions Patients with high SIRI value and low PNI value before ICI treatment have shorter PFS. Patients with higher PNI value have better prognosis. Therefore, hematological indicators may become predictors of immunotherapy

Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs

The purpose of this experiment was to evaluate the effects of low protein corn-soybean meal-based diets on fecal CP, amino acid (AA) flow amount, AA digestibility and fecal and ileal microbial AA composition in growing pigs. Eighteen pigs (initial body weight = 30 &plusmn; 1.35) were randomly divided into three groups and fed with basal diets with CP levels of 12%, 15% and 18%, respectively. The Lys, Met + Cys, Thr and Trp level in the 12% CP and 15% CP groups is the same as 18% CP group by the addition of four crystalline Lys, Met + Cys, Thr and Trp to the diet. The results showed that with the decrease of dietary CP level from 18% to 12%, the fecal total nitrogen (N), CP and total AA (TAA) flow amount decreased linearly (p &lt; 0.05). Dry matter (DM) digestibility, CP digestibility, TAA digestibility, essential amino acid (EAA) digestibility and non-essential amino acid (NEAA) digestibility increased linearly with the decrease of dietary CP concentration from 18% to 12%. Compared with 18% CP group, the flow amount of Asp, Ser, Glu, Gly, Tyr, Val, Leu and Phe in feces of pigs in the 15% CP group and 12% CP group decreased significantly, while the flow amount of Arg in the 15% CP group was lower than that in the 18% CP group and 12% CP group. The fecal microbial N and AA of the 15% CP group were higher than those of the 18% CP and 12% CP groups. Fecal TAA flow amount decreased linearly with the decrease of the dietary CP levels from 18% to 12%. Fecal TAA and NEAA flow amount also decreased linearly with the decrease of dietary CP level from 18% to 12%. Except for Glu, Gly, Met, Tyr, Thr and Phe, there were significant differences among the three groups in the composition of 17 kinds of AAs in fecal microorganisms. Among the 17 AA compositions of ileal microorganisms, except Tyr and Lys, the other AAs were significantly different among the three groups (p &lt; 0.05