Smart Materials for Wearable Healthcare Devices

Wearable devices seem to have great potential that could result in a revolutionary non-clinical approach to health monitoring and diagnosing disease. With continued innovation and intensive attention to the materials and fabrication technologies, development of these healthcare devices is progressively encouraged. This chapter gives a concise review of some of the main concepts and approaches related to recent advances and developments in the scope of wearable devices from the perspective of emerging materials. A complementary section of the review linking these advanced materials with wearable device technologies is particularly specified. Some of the strong and weak points in development of each wearable material/device are clearly highlighted and criticized

Design of Novel Fire Rescue System Based on Wireless Sensor Network

This document presents an innovative system for the traditional air respirator used for fire rescue. This system took advantage of the Micro-Electro-Mechanical Systems inertial acceleration sensor to supervise the real time posture of the personnel, conducted the pressure measurement by replacing the mechanical watch with electronic pressure transmitter, and transferred the residual aeration to the helmet and handheld instrument of the team members with 433 MHz wireless sensor network. The handheld collected the information, and sent it to the remote command center through the telecom General Packet Radio Service network. The management software can achieve the real-time information from the firemen. The system has a great significance in real application, which guarantees the life safety of the firemen to a great degree, and changes the situation in which each fireman is an information isolated island

Design of Novel Fire Rescue System Based on Wireless Sensor Network

Abstract: This document presents an innovative system for the traditional air respirator used for fire rescue. This system took advantage of the Micro-Electro-Mechanical Systems inertial acceleration sensor to supervise the real time posture of the personnel, conducted the pressure measurement by replacing the mechanical watch with electronic pressure transmitter, and transferred the residual aeration to the helmet and handheld instrument of the team members with 433 MHz wireless sensor network. The handheld collected the information, and sent it to the remote command center through the telecom General Packet Radio Service network. The management software can achieve the real-time information from the firemen. The system has a great significance in real application, which guarantees the life safety of the firemen to a great degree, and changes the situation in which each fireman is an information isolated island

Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.

BACKGROUND: In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times. METHODS: Focus group discussions were conducted with dengue patients, from before and after the POCT implementation period. In-depth interviews with semi-structured components with healthcare workers were carried out. A patient centred process mapping technique was used for evaluation, which mapped the patient's journey and was mirrored from the healthcare worker's perspective. RESULTS: Patients and healthcare workers confirmed a wide range of symptoms in adults, making it challenging to determine diagnosis. There were multiple routes to help seeking, and no 'typical patient journey', with patients either presenting directly to the hospital emergency department, or being referred there by a primary care provider. Patients groups diagnosed before and after POCT implementation expressed some differences between speed of diagnoses and attitudes of doctors, yet shared negative feelings about waiting times and a lack of communication and poor information delivery. However, the POCT did not in its current implementation do much to help waiting times. Healthcare workers expressed that public perceptions of dengue in recent years was a major factor in changing patient management, and that the POCT kit was helpful in improving the speed and accuracy of diagnoses. CONCLUSIONS: Health service delivery for dengue patients in Singapore was overall perceived to be of an acceptable clinical standard, which was enhanced by the introduction of the POCT. However, improvements can be focused on Adapting to outbreaks by reducing and rendering Waiting experiences more comfortable; Advancing education about symptom recognition, while also Recognising better communication strategies; and Expanding follow-up care options. This is presented as the Dengue AWARE model of care delivery

Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting

Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the growth of cancer cells and, ideally also precancerous cells for early prevention, but minimally affect their normal counterparts. Using genetic mouse models with neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) as the cells‐of‐origin/mutation, it is shown that the susceptibility of cells within the development hierarchy of glioma to the knockout of insulin‐like growth factor I receptor (IGF1R) is determined not only by their oncogenic states, but also by their cell identities/states. Knockout of IGF1R selectively disrupts the growth of mutant and transformed, but not normal OPCs, or NSCs. The desirable outcome of IGF1R knockout on cell growth requires the mutant cells to commit to the OPC identity regardless of its development hierarchical status. At the molecular level, oncogenic mutations reprogram the cellular network of OPCs and force them to depend more on IGF1R for their growth. A new‐generation brain‐penetrable, orally available IGF1R inhibitor harnessing tumor OPCs in the brain is also developed. The findings reveal the cellular window of IGF1R targeting and establish IGF1R as an effective target for the prevention and treatment of glioblastoma

CNS-LAND score: predicting early neurological deterioration after intravenous thrombolysis based on systemic responses and injury

ImportanceEarly neurological deterioration (END) is a critical complication in acute ischemic stroke (AIS) patients receiving intravenous thrombolysis (IVT), with a need for reliable prediction tools to guide clinical interventions.ObjectiveThis study aimed to develop and validate a rating scale, utilizing clinical variables and multisystem laboratory evaluation, to predict END after IVT.Design, setting, and participantsThe Clinical Trial of Revascularization Treatment for Acute Ischemic Stroke (TRAIS) cohort enrolled consecutive AIS patients from 14 stroke centers in China (Jan 2018 to Jun 2022).OutcomesEND defined as NIHSS score increase >4 points or death within 24 h of stroke onset.Results1,213 patients (751 in the derivation cohort, 462 in the validation cohort) were included. The CNS-LAND score, a 9-point scale comprising seven variables (CK-MB, NIHSS score, systolic blood pressure, LDH, ALT, neutrophil, and D-dimer), demonstrated excellent differentiation of END (derivation cohort C statistic: 0.862; 95% CI: 0.796–0.928) and successful external validation (validation cohort C statistic: 0.851; 95% CI: 0.814–0.882). Risk stratification showed END risks of 2.1% vs. 29.5% (derivation cohort) and 2.6% vs. 31.2% (validation cohort) for scores 0–3 and 4–9, respectively.ConclusionCNS-LAND score is a reliable predictor of END risk in AIS patients receiving IVT

The DNA Methylome of Human Peripheral Blood Mononuclear Cells

Analysis across the genome of patterns of DNA methylation reveals a rich landscape of allele-specific epigenetic modification and consequent effects on allele-specific gene expression

Precessing jet nozzle connecting to a spinning black hole in M87

The nearby radio galaxy M87 offers a unique opportunity to explore the connections between the central supermassive black hole and relativistic jets. Previous studies of the inner region of M87 revealed a wide opening angle for the jet originating near the black hole. The Event Horizon Telescope resolved the central radio source and found an asymmetric ring structure consistent with expectations from General Relativity. With a baseline of 17 years of observations, there was a shift in the jet's transverse position, possibly arising from an eight to ten-year quasi-periodicity. However, the origin of this sideways shift remains unclear. Here we report an analysis of radio observations over 22 years that suggests a period of about 11 years in the position angle variation of the jet. We infer that we are seeing a spinning black hole that induces the Lense-Thirring precession of a misaligned accretion disk. Similar jet precession may commonly occur in other active galactic nuclei but has been challenging to detect owing to the small magnitude and long period of the variation.Comment: 41 pages, 7 figures, 7 table

A single slot micro-ring structure for simultaneous CO

In this paper, we proposed a single silicon-on-insulator micro-ring structure for detecting two different gas components in the same time from one output spectrum. By introducing slot structure, the sensitivity and selectivity of sensor are improved. Specifically, two different sensing mechanisms are synthesized in this structure, thus output spectrum is impacted by varying concentrations of CH4 and CO2 respectively. The resonant wavelength of micro-ring resonator is the absorption peak of CH4, the concentration of CH4 can be measured with the light intensity change. Simultaneously, the combined action of CH4 and CO2 can cause the shift of resonant wavelength, and the total concentration of CH4 and CO2 gas can be obtained through the shift amount. For enhancing the evanescent field fraction in slot area and tuning the resonant wavelength of micro-ring being located on the absorption peak of CH4 (around 3.31 µm), the parameters of slot micro-ring structure, including height of slot in silicon, slot width, radius of micro-ring, waveguide width and the gap distance in coupling section, are well tailored, meanwhile, the quality factor Q of micro-ring is considered for ensuring a satisfied accuracy of sensor. A simulation based on the finite difference time domain method is implemented and the analysis results show that the sensitivity of sensor reaches 2308 nm/refractive index unit