HS-Diffusion: Learning a Semantic-Guided Diffusion Model for Head Swapping

Image-based head swapping task aims to stitch a source head to another source body flawlessly. This seldom-studied task faces two major challenges: 1) Preserving the head and body from various sources while generating a seamless transition region. 2) No paired head swapping dataset and benchmark so far. In this paper, we propose an image-based head swapping framework (HS-Diffusion) which consists of a semantic-guided latent diffusion model (SG-LDM) and a semantic layout generator. We blend the semantic layouts of source head and source body, and then inpaint the transition region by the semantic layout generator, achieving a coarse-grained head swapping. SG-LDM can further implement fine-grained head swapping with the blended layout as condition by a progressive fusion process, while preserving source head and source body with high-quality reconstruction. To this end, we design a head-cover augmentation strategy for training and a neck alignment trick for geometric realism. Importantly, we construct a new image-based head swapping benchmark and propose two tailor-designed metrics (Mask-FID and Focal-FID). Extensive experiments demonstrate the superiority of our framework. The code will be available: https://github.com/qinghew/HS-Diffusion

Bottom-up growth of n-type monolayer molecular crystals on polymeric substrate for optoelectronic device applications.

Self-assembly of monolayers of functional molecules on dielectric surfaces is a promising approach for the development of molecular devices proposed in the 1970s. Substrate chemically bonded self-assembled monolayers of semiconducting conjugated molecules exhibit low mobility. And self-assembled monolayer molecular crystals are difficult to scale up and limited to growth on substrates terminated by hydroxyl groups, which makes it difficult to realize sophisticated device functions, particularly for those relying on n-type electron transport, as electrons suffer severe charge trapping on hydroxyl terminated surfaces. Here we report a gravity-assisted, two-dimensional spatial confinement method for bottom-up growth of high-quality n-type single-crystalline monolayers over large, centimeter-sized areas. We demonstrate that by this method, n-type monolayer molecular crystals with high field-effect mobility of 1.24 cm2 V-1 s-1 and band-like transport characteristics can be grown on hydroxyl-free polymer surface. Furthermore, we used these monolayer molecular crystals to realize high-performance crystalline, gate-/light-tunable lateral organic p-n diodes

Optical and SuperDARN radar observations of duskside shock aurora over Zhongshan Station

We present observations of a duskside shock aurora occurred on 21 April 2001 by the SuperDARN radar at Syowa Station and the all-sky camera at Zhongshan Station (ZHS) in Antarctica when the radar was operated in fast-scan mode covering the ZHS region. With the two independent data sets, we examine ionospheric plasma convection and aurora arising from a sudden impulse (SI) event associated with an interplanetary shock. During the transient shock compression, the aurora was quiescent without any optical emission at the preliminary impulse of the SI. About 7 min later, a new thin auroral arc with brighter emissions and a lifetime of ~14 min expanded westward from the region above ZHS during the main impulse of the SI. SuperDARN radar line-of-sight measurements showed periodical oscillation in the flow direction with ultra-low-frequency waves having a period of ~8 min during the shock compression. We suggest that downward field-aligned current during the preliminary impulse stage of the SI was the main driver of the first plasma flow reversal, and the subsequent new discrete auroral arc may be associated with field-aligned acceleration in the region of the main impulse related upward field-aligned currents. The ground magnetometer observations suggest that the oscillation of the ionospheric convection on the duskside was associated with field line resonance activity

Simultaneous optical and radar observations of poleward moving auroral forms under different IMF conditions

Using high temporal resolution optical data obtained from three-wavelength all-sky imagers at Chinese Yellow River Station in the Arctic, together with the EISCAT Svalbard radar (ESR) and SuperDARN radars, we investigated the dayside poleward moving auroral forms (PMAFs) and the associated plasma features in the polar ionosphere under different interplanetary magnetic field (IMF) conditions, between 0900 and 1010 UT on 22 December 2003. Simultaneous optical and ESR observations revealed that all PMAFs were clearly associated with pulsed particle precipitations. During northward IMF, particles can precipitate into lower altitudes and reach the ionospheric E-region, and there is a reverse convection cell associated with these PMAFs. This cell is one of the typical signatures of the dayside high-latitude (lobe) reconnection in the polar ionosphere. These results indicate that the PMAFs were associated with the high-latitude reconnection. During southward IMF, the PMAFs show larger latitudinal motion, indicating a longer mean lifetime, and the associated ionospheric features indicate that the PMAFs were generated by the dayside low-latitude reconnection

Genome-Wide Mapping of DNA Methylation in Chicken

Cytosine DNA methylation is an important epigenetic modification termed as the fifth base that functions in diverse processes. Till now, the genome-wide DNA methylation maps of many organisms has been reported, such as human, Arabidopsis, rice and silkworm, but the methylation pattern of bird remains rarely studied. Here we show the genome-wide DNA methylation map of bird, using the chicken as a model organism and an immunocapturing approach followed by high-throughput sequencing. In both of the red jungle fowl and the avian broiler, DNA methylation was described separately for the liver and muscle tissue. Generally, chicken displays analogous methylation pattern with that of animals and plants. DNA methylation is enriched in the gene body regions and the repetitive sequences, and depleted in the transcription start site (TSS) and the transcription termination site (TTS). Most of the CpG islands in the chicken genome are kept in unmethylated state. Promoter methylation is negatively correlated with the gene expression level, indicating its suppressive role in regulating gene transcription. This work contributes to our understanding of epigenetics in birds

Contributions to the cross shock electric field at supercritical perpendicular shocks: Impact of the pickup ions

A particle-in-cell code is used to examine contributions of the pickup ions (PIs) and the solar wind ions (SWs) to the cross shock electric field at the supercritical, perpendicular shocks. The code treats the pickup ions self-consistently as a third component. Herein, two different runs with relative pickup ion density of 25% and 55% are presented in this paper. Present preliminary results show that: (1) in the low percentage (25%) pickup ion case, the shock front is nonstationary. During the evolution of this perpendicular shock, a nonstationary foot resulting from the reflected solar wind ions is formed in front of the old ramp, and its amplitude becomes larger and larger. At last, the nonstationary foot grows up into a new ramp and exceeds the old one. Such a nonstationary process can be formed periodically. hen the new ramp begins to be formed in front of the old ramp, the Hall term mainly contributed by the solar wind ions becomes more and more important. The electric field Ex is dominated by the Hall term when the new ramp exceeds the old one. Furthermore, an extended and stationary foot in pickup ion gyro-scale is located upstream of the nonstationary/self-reforming region within the shock front, and is always dominated by the Lorentz term contributed by the pickup ions; (2) in the high percentage (55%) pickup ion case, the amplitude of the stationary foot is increased as expected. One striking point is that the nonstationary region of the shock front evidenced by the self-reformation disappears. Instead, a stationary extended foot dominated by Lorentz term contributed by the pickup ions, and a tationary ramp dominated by Hall term contributed by the solar wind ions are clearly evidenced. The significance of the cross electric field on ion dynamics is also discussed.Comment: 11 pages, 6 figs and 1 table. This paper will be published in the journal: Astrophysics and Space Scienc

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because of its diverse pharmacological characteristics. Although resveratrol possesses chemopreventive properties against several cancers, the molecular mechanisms by which it inhibits cell growth and induces apoptosis have not been clearly understood. The present study was carried out to examine whether PI3K/AKT/FOXO pathway mediates the biological effects of resveratrol.Resveratrol inhibited the phosphorylation of PI3K, AKT and mTOR. Resveratrol, PI3K inhibitors (LY294002 and Wortmannin) and AKT inhibitor alone slightly induced apoptosis in LNCaP cells. These inhibitors further enhanced the apoptosis-inducing potential of resveratrol. Overexpression of wild-type PTEN slightly induced apoptosis. Wild type PTEN and PTEN-G129E enhanced resveratrol-induced apoptosis, whereas PTEN-G129R had no effect on proapoptotic effects of resveratrol. Furthermore, apoptosis-inducing potential of resveratrol was enhanced by dominant negative AKT, and inhibited by wild-type AKT and constitutively active AKT. Resveratrol has no effect on the expression of FKHR, FKHRL1 and AFX genes. The inhibition of FOXO phosphorylation by resveratrol resulted in its nuclear translocation, DNA binding and transcriptional activity. The inhibition of PI3K/AKT pathway induced FOXO transcriptional activity resulting in induction of Bim, TRAIL, p27/KIP1, DR4 and DR5, and inhibition of cyclin D1. Similarly, resveratrol-induced FOXO transcriptional activity was further enhanced when activation of PI3K/AKT pathway was blocked. Over-expression of phosphorylation deficient mutants of FOXO proteins (FOXO1-TM, FOXO3A-TM and FOXO4-TM) induced FOXO transcriptional activity, which was further enhanced by resveratrol. Inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/KIP1 and apoptosis, and inhibition of cyclin D1 by resveratrol.These data suggest that FOXO transcription factors mediate anti-proliferative and pro-apoptotic effects of resveratrol, in part due to activation of extrinsic apoptosis pathway

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Unique solvability of the CCD scheme for convection–diffusion equations with variable convection coefficients

Abstract The combined compact difference (CCD) scheme has better spectral resolution than many other existing compact or noncompact high-order schemes, and is widely used to solve many differential equations. However, due to its implicit nature, very little theoretical results on the CCD method are known. In this paper, we provide a rigorous theoretical proof for the unique solvability of the CCD scheme for solving the convection-diffusion equation with variable convection coefficients subject to periodic boundary conditions