Gender-specific association between blood cell parameters and hyperuricemia in high-altitude areas

BackgroundHyperuricemia is a common metabolic disorder linked to various health conditions. Its prevalence varies among populations and genders, and high-altitude environments may contribute to its development. Understanding the connection between blood cell parameters and hyperuricemia in high-altitude areas can shed light on the underlying mechanisms. This study aimed to investigate the relationship between blood cell parameters and hyperuricemia in high-altitude areas, with a particular focus on gender differences.MethodsWe consecutively enrolled all eligible Tibetan participants aged 18–60 who were undergoing routine medical examinations at the People’s Hospital of Chaya County between January and December 2022. During this period, demographic and laboratory data were collected to investigate the risk factors associated with hyperuricemia.ResultsAmong the participants, 46.09% were diagnosed with hyperuricemia. In the male cohort, significant correlations were found between serum uric acid (SUA) levels and red blood cell (RBC) count, creatinine (Cr). Urea, alanine transaminase (ALT), and albumin (ALB). Notably, RBC exhibited the strongest association. Conversely, in the female cohort, elevated SUA levels were associated with factors such as white blood cell (WBC) count. Urea, ALT, and ALB, with WBC demonstrating the most significant association. Further analysis within the female group revealed a compelling relationship between SUA levels and specific white blood cell subtypes, particularly neutrophils (Neu).ConclusionThis study revealed gender-specific associations between SUA levels and blood cell parameters in high-altitude areas. In males, RBC count may play a role in hyperuricemia, while in females, WBC count appears to be a significant factor. These findings contribute to our understanding of metabolic dynamics in high-altitude regions but require further research for comprehensive mechanistic insights

Complex Dynamics Analysis of a Discrete Amensalism System with a Cover for the First Species

Of interest is the dynamics of the discrete-time amensalism model with a cover on the first species. We first obtain the existence and stability of fixed points and the conditions for the permanent coexistence of two species. Then we demonstrate the occurrence of flip bifurcation by using the central manifold theorem and bifurcation theory. A hybrid control strategy is used to control the flip bifurcation and stabilize unstable periodic orbits embedded in the complex attractor. Numerical simulation verifies the feasibility of theoretical analysis and reveals some novel and exciting dynamic phenomena

Lifelong Learning for Minimizing Age of Information in Internet of Things Networks

In this paper, a lifelong learning problem is studied for an Internet of Things (IoT) system. In the considered model, each IoT device aims to balance its information freshness and energy consumption tradeoff by controlling its computational resource allocation at each time slot under dynamic environments. An unmanned aerial vehicle (UAV) is deployed as a flying base station so as to enable the IoT devices to adapt to novel environments. To this end, a new lifelong reinforcement learning algorithm, used by the UAV, is proposed in order to adapt the operation of the devices at each visit by the UAV. By using the experience from previously visited devices and environments, the UAV can help devices adapt faster to future states of their environment. To do so, a knowledge base shared by all devices is maintained at the UAV. Simulation results show that the proposed algorithm can converge 25% to 50% faster than a policy gradient baseline algorithm that optimizes each device's decision making problem in isolation

Micro-CT Evaluation of Different Root Canal Irrigation Protocols on the Removal of Accumulated Hard Tissue Debris: A Systematic Review and Meta-Analysis

Accumulated hard tissue debris (AHTD) is an inevitable by-product during endodontic treatment and is difficult to remove completely using traditional syringe and needle irrigation (SNI). Adjunctive irrigation is proposed to assist the clean-up of AHTD. This systematic review and meta-analysis aimed to evaluate the AHTD removal efficacy of different root canal irrigation devices using micro-computed tomography (Micro-CT). A literature search was carried out within the main scientific databases until 20 June 2022. All results were screened with detailed eligibility criteria. Eleven studies were included for analysis. SNI, passive ultrasonic irrigation (PUI), negative pressure systems, sonically activated irrigation (SAI), mechanical-activated system and laser-activated irrigation (LAI) were assessed. PUI is superior to SNI for debris removal and LAI has better AHTD removal performance than PUI. The negative pressure system and mechanical-activated system were proved to be less effective. Registration: PROSPERO (CRD42021273892)

Associations of IFT20 and GM130 protein expressions with clinicopathological features and survival of patients with lung adenocarcinoma

Abstract Background Lung cancer is the leading cause of malignancy-related mortality and lung adenocarcinoma accounts for about 40% of lung malignancies. The aim of this study was to investigate the associations of intraflagellar transport protein 20 (IFT20) and Golgi matrix protein 130 (GM130) expression with clinicopathological features and survival in patients with lung adenocarcinoma. Methods The expressions of IFT20 and GM130 protein in cancerous and matched adjacent lung tissues of 235 patients with lung adenocarcinoma were assessed by tissue microarray and immunohistochemistry, which were indicated by the mean optical density (IOD/area), the rate of positive staining cells and staining intensity score. The correlation between IFT20 and GM130 protein was assessed by Spearman’s rank correlation. Associations of IFT20 and GM130 protein expression with clinicopathological features of patients were analyzed by multivariate logistic regression models. The survival analysis of patients was performed by Cox proportional hazard regression models. Results With adjustment for multiple potential confounders, each one-point increase in IFT20 protein staining intensity score was significantly associated with 32% and 29% reduced risk for TNM stage in II ~ IV and lymphatic metastasis of patients, respectively (P  7 cm by 29% and 38% for lung adenocarcinoma patients, respectively (P  7 cm or distant metastasis by 54% and 65%, respectively (P < 0.05). Conclusion IFT20 and GM130 protein expressions were negatively associated with tumor differentiated types, size, TNM stage and lymphatic metastasis of lung adenocarcinoma. Both IFT20 and GM130 proteins have some protective effects on the survival of lung adenocarcinoma patients with specific clinicopathological features