44 research outputs found

    Weighted Lp-stability For Localized Infinite Matrices

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    This dissertation originates from a classical result that the lp-stability of the convolution operator associated with a summable sequence are equivalent to each other for different p . This dissertation is motivated by the recent result by C. E. Shin and Q. Sun (Journal ofFunctional Analysis, 256(2009), 2417-2439), where the lp-stability of infinite matrices in the Gohberg-Baskakov-Sjostrand class are proved to be equivalent to each other for different p. In the dissertation, for an infinite matrix having certain off-diagonal decay, its weighted lp-stability for different p are proved to be equivalent to each other and hence a result by Shin and Sun is generalized

    Validation of the Alzheimer's disease-resemblance atrophy index in classifying and predicting progression in Alzheimer's disease

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    BACKGROUND: Automated tools for characterising dementia risk have the potential to aid in the diagnosis, prognosis, and treatment of Alzheimer’s disease (AD). Here, we examined a novel machine learning-based brain atrophy marker, the AD-resemblance atrophy index (AD-RAI), to assess its test-retest reliability and further validate its use in disease classification and prediction. METHODS: Age- and sex-matched 44 probable AD (Age: 69.13 ± 7.13; MMSE: 27–30) and 22 non-demented control (Age: 69.38 ± 7.21; MMSE: 27–30) participants were obtained from the Minimal Interval Resonance Imaging in Alzheimer’s Disease (MIRIAD) dataset. Serial T1-weighted images (n = 678) from up to nine time points over a 2-year period, including 179 pairs of back-to-back scans acquired on same participants on the same day and 40 pairs of scans acquired at 2-week intervals were included. All images were automatically processed with AccuBrain® to calculate the AD-RAI. Its same-day repeatability and 2-week reproducibility were first assessed. The discriminative performance of AD-RAI was evaluated using the receiver operating characteristic curve, where DeLong’s test was used to evaluate its performance against quantitative medial temporal lobe atrophy (QMTA) and hippocampal volume adjusted by intracranial volume (ICV)-proportions and ICV-residuals methods, respectively (HVR and HRV). Linear mixed-effects modelling was used to investigate longitudinal trajectories of AD-RAI and baseline AD-RAI prediction of cognitive decline. Finally, the longitudinal associations between AD-RAI and MMSE scores were assessed. RESULTS: AD-RAI had excellent same-day repeatability and excellent 2-week reproducibility. AD-RAI’s AUC (99.8%; 95%CI = [99.3%, 100%]) was equivalent to that of QMTA (96.8%; 95%CI = [92.9%, 100%]), and better than that of HVR (86.8%; 95%CI = [78.2%, 95.4%]) or HRV (90.3%; 95%CI = [83.0%, 97.6%]). While baseline AD-RAI was significantly higher in the AD group, it did not show detectable changes over 2 years. Baseline AD-RAI was negatively associated with MMSE scores and the rate of the change in MMSE scores over time. A negative longitudinal association was also found between AD-RAI values and the MMSE scores among AD patients CONCLUSIONS: The AD-RAI represents a potential biomarker that may support AD diagnosis and be used to predict the rate of future cognitive decline in AD patients

    Design and Fabrication of an Artificial Compound Eye for Multi-Spectral Imaging

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    The artificial compound eye (ACE) structure is a new type of miniaturized, lightweight and intelligent imaging system. This paper has proposed to design a multi-spectral ACE structure to enable the structure to achieve multi-spectral information on the basis of imaging. The sub-eyes in the compound eye structure have been designed as diffractive beam splitting lenses with the same focal length of 20 mm, but with the different designed center wavelengths of 650 nm, 532 nm, and 445 nm, respectively. The proximity exposure lithography and reactive ion etching process were used to prepare the designed multi-spectral ACE structure, and the spectral splitting and multi-spectral imaging experiments were carried out to verify the multi-spectral imaging function of the structure without axial movement. Furthermore, the structure can be designed according to actual requirements, which can be applied to covert reconnaissance, camouflage identification, gas leakage or other fields

    Alternative Design of Dammann Grating for Beam Splitting With Adjustable Zero-Order Light Intensity

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    Fabrication of Random Microwell Arrays as Pseudo-Thermal Speckle Light Source

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    Quantum correlated imaging using the intensity fluctuations of thermal light possesses advantages of high resolution and strong anti-interference ability. The common method to produce pseudo-thermal light source is using a rotary ground glass and transmission of laser beam. In the present work, we propose a method for the fabrication of microwell arrays with randomly varied diameters, which could be used as a new structural element for pseudo-thermal speckle light source. If these are etched with random sizes then they may also have random and complex varying curvatures (diffusion limited etching) leading to random destructive interference of the coherent beam which could be a good thing. The microwell arrays, with diameters randomly varying from 5 μm to 40 μm, height varying from 200 nm to 20 μm, were fabricated by photolithography combined with acid etching. The experimental conditions are simple and can be scaled up to for large structures. The produced microwell arrays can transform the laser beam to a pseudo-thermal light source with a certain divergent angle by rational designing of mask and adjustable process parameters

    Leaf phenology rather than mycorrhizal type regulates soil nematode abundance, but collectively affects nematode diversity in seven common subtropical tree species

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    The underlying mechanisms of the relationships between tree species and the soil micro-food web in forest ecosystems remain uncertain, primarily ascribed to an insufficient understanding on how tree functional traits drive soil nematode communities, including in subtropical forests. We investigated the impacts of seven subtropical tree species (evergreen: Pinus massoniana, Mytilaria laosensis, Ilex chinensis, Michelia macclurei; and deciduous: Liquidambar formosana, Quercus acutissima, and Betula luminifera) on the soil nematode communities. We found that the abundance of soil nematodes was not affected by mycorrhizal types, but it was around 83% higher under the deciduous trees than the evergreen trees, indicating the importance of leaf phenology to the abundance of soil nematodes. Nonetheless, both the evergreen and the arbuscular mycorrhizal trees increased soil nematode diversity, resulting from changes in root traits and soil properties. Furthermore, root traits (root C, root N, and root C:N ratio), and soil properties (total C, total N, moisture content, and bulk density) were the best predictors of the community composition of soil nematodes, indicating a key role of resource quality and soil microhabitat in regulating soil nematodes. In contrast, the ectomycorrhizal trees had lower plant parasite and Wasilewska indices, and evenness, whereas the evergreen trees slightly improved the evenness of soil nematodes. This study suggests that tree species affect the soil food web through changes in soil conditions and plant functional traits in subtropical forests

    HSP70 Gene Family in <i>Brassica rapa</i>: Genome-Wide Identification, Characterization, and Expression Patterns in Response to Heat and Cold Stress

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    Heat shock proteins protect plants from abiotic stress, such as salt, drought, heat, and cold stress. HSP70 is one of the major members of the heat shock protein family. To explore the mechanism of HSP70 in Brassica rapa, we identified 28 putative HSP70 gene family members using state-of-the-art bioinformatics-based tools and methods. Based on chromosomal mapping, HSP70 genes were the most differentially distributed on chromosome A03 and the least distributed on chromosome A05. Ka/Ks analysis revealed that B. rapa evolution was subjected to intense purifying selection of the HSP70 gene family. RNA-sequencing data and expression profiling showed that heat and cold stress induced HSP70 genes. The qRT-PCR results verified that the HSP70 genes in Chinese cabbage (Brassica rapa ssp. pekinensis) are stress-inducible under both cold and heat stress. The upregulated expression pattern of these genes indicated the potential of HSP70 to mitigate environmental stress. These findings further explain the molecular mechanism underlying the responses of HSP70 to heat and cold stress

    Design and Fabrication of Flexible Naked-Eye 3D Display Film Element Based on Microstructure

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    The naked-eye three-dimensional (3D) display technology without wearing equipment is an inevitable future development trend. In this paper, the design and fabrication of a flexible naked-eye 3D display film element based on a microstructure have been proposed to achieve a high-resolution 3D display effect. The film element consists of two sets of key microstructures, namely, a microimage array (MIA) and microlens array (MLA). By establishing the basic structural model, the matching relationship between the two groups of microstructures has been studied. Based on 3D graphics software, a 3D object information acquisition model has been proposed to achieve a high-resolution MIA from different viewpoints, recording without crosstalk. In addition, lithography technology has been used to realize the fabrications of the MLA and MIA. Based on nanoimprint technology, a complete integration technology on a flexible film substrate has been formed. Finally, a flexible 3D display film element has been fabricated, which has a light weight and can be curled

    Nanobowl Array Fabrication via Conglutination Process Based on Thiol–Ene Polymer

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