Design and Planning of Commercial Streets with Cultural Attraction Theme

As a major attraction of tourism and recreation, commercial streets are common gathering places in urban life, offering a constellation of goods, sightseeing and entertainment. According to McKinsey team, history, unique of landscape and business models are key elements that influence the formation of commercial streets. In this paper, I will develop two case studies about Wangfujing Street and Qianmen Dajie Street in Beijing to further demonstrate the importance of those elements. Around those key elements, historical features will be my research focus for the uniqueness of Beijing as an ancient capital of China. Based on the data collected from my case studies, I intend to show that historical features are one of the most influential elements in the formation of a commercial street in Beijing. I also argue that the lack of historic preservation may hamper the development of an already crowded commercial street in the long run

Ground state solutions to a coupled nonlinear logarithmic Hartree system

In this paper, we study the following coupled nonlinear logarithmic Hartree system \begin{align*} \left\{ \displaystyle \begin{array}{ll} \displaystyle -\Delta u+ \lambda_1 u =\mu_1\left( -\frac{1}{2\pi}\ln(|x|) \ast u^2 \right)u+\beta \left( -\frac{1}{2\pi}\ln(|x|) \ast v^2 \right)u, & x \in ~ \mathbb R^2, \vspace{.4cm}\\ -\Delta v+ \lambda_2 v =\mu_2\left( -\frac{1}{2\pi}\ln(|x|) \ast v^2 \right)v +\beta\left( -\frac{1}{2\pi}\ln(|x|) \ast u^2 \right)v, & x \in ~ \mathbb R^2, \end{array} \right.\hspace{1cm} \end{align*} where $\beta, \mu_i, \lambda_i \ (i=1,2)$ are positive constants, $\ast$ denotes the convolution in $\mathbb R^2$. By considering the constraint minimum problem on the Nehari manifold, we prove the existence of ground state solutions for $\beta>0$ large enough. Moreover, we also show that every positive solution is radially symmetric and decays exponentially

An in-depth investigation of the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine [preprint]

BACKGROUND: 50 In-depth investigations of the safety and immunogenicity of inactivated SARS-CoV-2 vaccines 51 are needed. 52 METHOD: 53 In a phase I randomized, double-blinded, and placebo-controlled trial involving 192 healthy 54 adults 18-59 years of age, two injections of three different doses (50 EU, 100 EU and 150 EU) 55 of an inactivated SARS-CoV-2 vaccine or the placebo were administered intramuscularly with 56 a 2- or 4-week interval between the injections. The safety and immunogenicity of the vaccine 57 were evaluated within 28 days. 58 FINDING: 59 In this study, 191 subjects assigned to three doses groups or the placebo group completed 60 the 28-day trial. There were 44 adverse reactions within the 28 days, most commonly mild 61 pain and redness at the injection site or slight fatigue, and no abnormal variations were 62 observed in 48 cytokines in the serum samples of immunized subjects. The serum samples 63 diluted from 1:32 to 1:4096 and incubated with the virus did not show antibody-dependent 64 enhancement effects (ADEs) with regard to human natural killer cells, macrophages or 65 dendritic cells. At day 14, the seroconversion rates had reached 92%, 100% and 96% with 66 geometric mean titers (GMTs) of 18.0, 54.5 and 37.1, and at day 28, the seroconversion rates 67 had reached 80%, 96% and 92% with GMTs of 10.6, 15.4 and 19.6in 0, 14 and 0, 28 68 procedures, respectively. Seroconversion was associated with the synchronous upregulation 69 of ELISA antibodies against the S protein, N protein and virion and a cytotoxic T lymphocyte 70 (CTL) response. Transcriptome analysis shaped the genetic diversity of immune response 71 induced by the vaccine. 72 INTERPRETATION: It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2020.09.27.20189548.this version posted October 6, 2020. The copyright holder for this preprint 4 73 In a population aged 18-59 years, this inactivated SARS-CoV-2 vaccine was safe and 74 immunogenic

Mechanics of Supercooled Liquids

Pure substances can often be cooled below their melting points and still remain in the liquid state. For some supercooled liquids, a further cooling slows down viscous flow greatly, but does not slow down self-diffusion as much. We formulate a continuum theory that regards viscous flow and self-diffusion as concurrent, but distinct, processes. We generalize Newton’s law of viscosity to relate stress, rate of deformation, and chemical potential. The self-diffusion flux is taken to be proportional to the gradient of chemical potential. The relative rate of viscous flow and self-diffusion defines a length, which, for some supercooled liquids, is much larger than the molecular dimension. A thermodynamic consideration leads to boundary conditions for a surface of liquid under the influence of applied traction and surface energy. We apply the theory to a cavity in a supercooled liquid and identify a transition. A large cavity shrinks by viscous flow, and a small cavity shrinks by self-diffusion.Engineering and Applied Science

A Novel DNA and Protein Combination COVID-19 Vaccine Formulation Provides Full Protection against SARS-CoV-2 in Rhesus Macaques

The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high -affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection