The growth and pluripotency of mesenchymal stem cell on the biodegradable polyurethane synthesized with ferric catalyst

<p>Polyurethane (PU) is a class of polymers that have been applied for tissue-engineering scaffolds. Cross-linked poly(ester urethane) (CPU), synthesized with ferric catalyst in our laboratory, was modified by silk fibroin (SF) grafting using our aminolysis and glutaradehyde crosslinking method. The physical and chemical properties of the materials were investigated by scanning electron microscope (SEM), atomic force microscope (AFM) and tensile tester. The results showed that SF grafted CPU possessed good strain and strength (4.29 ± 0.18 MPa/382.38 ± 0.71%). Its surface chemistry and roughness were fine to well support the growth of bone marrow mesenchymal stem cells (BMSC). The cells were verified to maintain the pluripotency after they were cultured <i>in vitro</i> for 2 weeks, which supplied us a good technology to keep cell’s stemness but proliferate cell’s number. These results are valuable for us to further study esophageal tissue engineering with BMSC and polyurethane materials as the components.</p

Clinical and cognitive features of the BSP patients based on the ACE-R scores.

<p>Clinical and cognitive features of the BSP patients based on the ACE-R scores.</p

Area and proportion of coupling coordination degree of landscape ecological security.

Area and proportion of coupling coordination degree of landscape ecological security.</p

Normative data of the healthy controls on the ACE-R (n = 68).

<p>Normative data of the healthy controls on the ACE-R (n = 68).</p

Sankey Map of landscape ecological security transfer from 1990 to 2020.

Sankey Map of landscape ecological security transfer from 1990 to 2020.</p

Screening for Cognitive Impairments in Primary Blepharospasm

<div><p>Backgrounds</p><p>Studies have reported that non-motor symptoms are an important component of primary dystonia. However, evidence supporting cognitive impairment in primary dystonia is limited and contradictory.</p><p>Methods</p><p>We applied the Chinese version of the Addenbrooke’s Cognitive Examination-Revised and the Mini-Mental State Examination (MMSE) to screen for cognitive impairment in patients with primary blepharospasm. In addition, we investigated the relationship between performance on the Addenbrooke’s Cognitive Examination-Revised and quality of life as measured by the Medical Outcomes Study 36-item Short-Form (SF36).</p><p>Results</p><p>The study included 68 primary blepharospasm patients and 68 controls matched by age, sex and education. The prevalence of cognitive deficits was 22.0% and 32.3% in primary blepharospasm patients group, as measured by the MMSE and the Addenbrooke’s Cognitive Examination-Revised, respectively. Primary blepharospasm patents had a broad range of cognitive deficits, with the most frequently affected domains being visuospatial function (30.9%) and language (30.9%), followed by memory (27.9%), orientation/attention (26.4%) and verbal fluency (22.0%). Patients with cognitive deficits had lower total SF36 scores, especially in the subdomains of physical functioning, role-physical and social functioning, compared to those without cognitive deficits. Scores on the Addenbrooke’s Cognitive Examination-Revised were significantly correlated with both the SF36 scores and the scores on the subdomains of physical functioning and social functioning.</p><p>Conclusions</p><p>Some patients with primary blepharospasm have cognitive deficits. Poor performance on the Addenbrooke’s Cognitive Examination-Revised is related to poorer quality of life.</p></div

Spatial distribution pattern of PLEL under different scenarios in 2030.

Republished from [57] under a CC BY license, with permission from Resource and environmental science data registration and publishing system, 2023.</p

Determinants of cognitive impairments based on the ACE-R cut-off score (<80) (Data were from those fifty patients not in receipt of oral medication.).

<p>Determinants of cognitive impairments based on the ACE-R cut-off score (<80) (Data were from those fifty patients not in receipt of oral medication.).</p

Relationship between the ACE-R and SF36 scores in BSP patients (n = 68).

<p>Relationship between the ACE-R and SF36 scores in BSP patients (n = 68).</p

PLEL distribution and local landscape ecological coupling coordination under EED scenario.

Republished from [57] under a CC BY license, with permission from Resource and environmental science data registration and publishing system, 2023.</p