31 research outputs found
Dynamic Discrete GM (1,1) Model and Its Application in the Prediction of Urbanization Conflict Events
In the empirical researches, the discrete GM (1,1) model is not always fitted well, and sometimes the forecasting error is large. In order to solve this issue, this study proposes a dynamic discrete GM (1,1) model based on the grey prediction theory and the GM (1,1) model. In this paper, we use the equal division technology to fit the concavity and convexity of the cumulative sequence and then construct two dynamic average values. Based on the dynamic average values, we further develop two dynamic discrete GM (1,1) models and provide the gradual heuristics method to draw the initial equal division number and the dichotomy approach to optimize the equal division number. Finally, based on an empirical analysis of the number of conflict events in the urbanization process in China, we verify that the dynamic discrete GM (1,1) model has higher fitting and prediction accuracy than the GM (1,1) model and the discrete GM (1,1) model, and its prediction result is beneficial to the government for prevention and solution of the urbanization conflict events
The aqueous supramolecular chemistry of crown ethers
This mini-review summarizes the seminal exploration of aqueous supramolecular chemistry of crown ether macrocycles. In history, most research of crown ethers were focusing on their supramolecular chemistry in organic phase or in gas phase. In sharp contrast, the recent research evidently reveal that crown ethers are very suitable for studying abroad range of the properties and applications of water interactions, from: high water-solubility, control of Hofmeister series, “structural water”, and supramolecular adhesives. Key studies revealing more details about the properties of water and aqueous solutions are highlighted
CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1 alpha
Cold-inducible RNA binding protein (CIRBP) has been reported to be associated with distinct tumorigenesis. In this study, we investigated the role of CIRBP in human bladder cancer (BCa), indicating that CIRBP is overexpressed in BCa tissues and cell lines to promote proliferation and migration. Moreover, CIRBP could induce expression of HIF-1 alpha via binding to the 3'-UTR of its mRNA to increase the mRNA stability in BCa cells. Furthermore, we demonstrated that PTGIS is a HIF-1 alpha targeted gene, a major regulator in hypoxic cancer progression by activating transcription of various oncogenes. Our results also suggested that overexpression of HIF-1 alpha may suppress the expression of PTGIS in BCa cells, by binding to HRE sequence at the promoter region of PTGIS. In addition, we found a strongly downregulation of PTGIS in BCa tissue and transcriptionally inhibited by HIF-1 alpha in BCa cells, which could be triggered by its DNA methylation. Further result suggested that knockdown of CIRBP could promote the expression of PTGIS, meanwhile knockdown of PTGIS could partially rescue CIRBP-deficiency induced inhibition of migration and proliferation in BCa cells. Taken together, our study indicated that CIRBP could be a novel oncogene in human bladder cancer inducing transcription of HIF-1 alpha, which could inhibit expression of methylated PTGIS
Eightfold Fermionic Excitation in a Charge Density Wave Compound
Unconventional quasiparticle excitations in condensed matter systems have
become one of the most important research frontiers. Beyond two- and fourfold
degenerate Weyl and Dirac fermions, three-, six- and eightfold symmetry
protected degeneracies have been predicted however remain challenging to
realize in solid state materials. Here, charge density wave compound TaTe4 is
proposed to hold eightfold fermionic excitation and Dirac point in energy
bands. High quality TaTe4 single crystals are prepared, where the charge
density wave is revealed by directly imaging the atomic structure and a
pseudogap of about 45 meV on the surface. Shubnikov de-Haas oscillations of
TaTe4 are consistent with band structure calculation. Scanning tunneling
microscopy reveals atomic step edge states on the surface of TaTe4. This work
uncovers that charge density wave is able to induce new topological phases and
sheds new light on the novel excitations in condensed matter materials.Comment: Accepted by PRB:
https://journals.aps.org/prb/accepted/7907cK4eW0b1ee0b93fd67c1b42942bbb08eafc3
Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis
Small activating RNA induces myogenic differentiation of rat adipose-derived stem cells by upregulating MyoD
Optimal Design of Cooperative Penetration Trajectories for Multiaircraft
At present, two kinds of shortages exist in the research on cooperative combat. One is that radar detection threat (which cannot be ignored) is rarely considered. The other is that limited efforts have been made on the cooperative penetration trajectories under the conditions of long distance, vast airspace, and wide speed range. In order to offset the shortages of the research on cooperative combat, the penetration trajectory optimization method considering the influence of aircraft radar cross-section (RCS) and the cooperative penetration strategy is proposed in this study. Firstly, the RCS data are calculated by the physical optics (PO) method. The radar detection threat model is established considering the influence of the aircraft RCS. Then, a trajectory optimization framework with the dynamic model, constraint conditions, and optimal objectives is formed. Using the hp-adaptive Radau pseudospectral method, the optimal control problem for a single aircraft flight is solved. Finally, a cooperative penetration strategy is proposed to solve the cooperative penetration problem of multiaircraft. The impact time and angle constraints are given, and the virtual target point is introduced for terminal guidance. Two cases are simulated and verified. Simulation results demonstrate that the proposed method is effective. The single aircraft can effectively penetrate, and the multiaircraft can fulfill the requirement of cooperative impact time and angle under the condition of meeting the minimum threat of radar detection
Impact Time Control Cooperative Guidance Law Design Based on Modified Proportional Navigation
The paper proposes a two-dimensional impact time control cooperative guidance law under constant velocity and a three-dimensional impact time control cooperative guidance law under time-varying velocity, which can both improve the penetration ability and combat effectiveness of multi-missile systems and adapt to the complex and variable future warfare. First, a more accurate time-to-go estimation method is proposed, and based on which a modified proportional navigational guidance (MPNG) law with impact time constraint is designed in this paper, which is also effective when the initial leading angle is zero. Second, adopting cooperative guidance architecture with centralized coordination, using the MPNG law as the local guidance, and the desired impact time as the coordination variables, a two-dimensional impact time control cooperative guidance law under constant velocity is designed. Finally, a method of solving the expression of velocity is derived, and the analytic function of velocity with respect to time is given, a three-dimensional impact time control cooperative guidance law under time-varying velocity based on desired impact time is designed. Numerical simulation results verify the feasibility and applicability of the methods
Multifidelity Multidisciplinary Design Optimization of Integral Solid Propellant Ramjet Supersonic Cruise Vehicles
Integral solid propellant ramjet (ISPR) supersonic cruise vehicles share the characteristic that they are highly integrated configurations. The traditional design of vehicles cannot achieve a balance between computational expense and accuracy. A multifidelity multidisciplinary design optimization (MDO) platform has been developed in this study. The focus of the platform is on ISPR supersonic cruise vehicles. Firstly, codes of discipline with different levels of fidelity (LoF) were established, such as geometry, aerodynamics, radar cross-section calculations, propulsion, mass, and trajectory discipline codes. Secondly, two MDO frameworks were constructed through discipline codes. A low LoF MDO framework is suitable for conceptual design, and a medium LoF MDO framework is suitable for preliminary design. Finally, taking the optimization problem with the minimum overall detection probability of flight trajectory as an example, the low LoF framework first explores the entire design space to achieve the mission requirements, and then, the medium LoF MDO framework accepts the low LoF framework optimization parameters. Hence, the optimization target is reached with more detailed parameters and higher fidelity. Additionally, an example for a solid propellant missile with minimum total mass is tested by the platform. The study results show that the multifidelity MDO framework not only exploits interactions between the disciplines but also improves the accuracy of optimization results and reduces the iteration time
Integrated analysis of aerodynamic/stealth characteristics of blended-wing-body lifting vehicle
In this paper, a blended-wing-body lifting vehicle is designed, with the cross section described by Class/Shape transformation method (CST), the outline controlled by an exponential function, and tail regulated by B-spline curve. Rapid estimation procedures of aerodynamic based on plane method and of radar cross section (RCS) based on physical optics are developed and validated. A frame of integrated design and analysis of aerodynamic and stealth characteristics is constructed and applied to parameter sensitivity analysis. The results show that the parameters that affect the aerodynamic differ from those of RCS, which means the vehicle could be good at both aerodynamic and stealth, and the study followed should be focused on it