Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients

Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility. Results. Serum PRL, LH, and T or E2 levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation (P < .05). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period. Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients

N′-[(E)-3-Indol-3-ylmethyl­ene]isonicotino­hydrazide monohydrate

Crystals of the title compound, C15H12N4O·H2O, were obtained from a condensation reaction of isonicotinylhydrazine and 3-indolylformaldehyde. The mol­ecule assumes an E configuration, with the isonicotinoylhydrazine and indole units located on the opposite sites of the C=N double bond. In the mol­ecular structure the pyridine ring is twisted with respect to the indole ring system, forming a dihedral angle of 44.72 (7)°. Extensive classical N—H⋯N, N—H⋯O, O—H⋯O and O—H⋯N hydrogen bonding and weak C—H⋯O inter­actions are present in the crystal structure

A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization

Many mitosis inhibitors are powerful anticancer drugs. Tremendous efforts have been made to identify new anti-mitosis compounds for developing more effective and less toxic anti-cancer drugs. We have identified LJK-11, a synthetic analog of 5, 8-disubstituted quinazolines, as a novel mitotic blocker. LJK-11 inhibited growth and induced apoptosis of many different types of tumor cells. It prevented mitotic spindle formation and arrested cells at early phase of mitosis. Detailed in vitro analysis demonstrated that LJK-11 inhibited microtubule polymerization. In addition, LJK-11 had synergistic effect with another microtubule inhibitor colchicine on blocking mitosis, but not with vinblastine or nocodazole. Therefore, LJK-11 represents a novel anti-microtubule structure. Understanding the function and mechanism of LJK-11 will help us to better understand the action of anti-microtubule agents and to design better anti-cancer drugs

Experimental measurement-device-independent quantum digital signatures over a metropolitan network

Quantum digital signatures (QDS) provide a means for signing electronic communications with informationtheoretic security. However, all previous demonstrations of quantum digital signatures assume trusted measurement devices. This renders them vulnerable against detector side-channel attacks, just like quantum key distribution. Here, we exploit a measurement-device-independent (MDI) quantum network, over a 200-square-kilometer metropolitan area, to perform a field test of a three-party measurement-device-independent quantum digital signature (MDI-QDS) scheme that is secure against any detector side-channel attack. In so doing, we are able to successfully sign a binary message with a security level of about 1E-7. Remarkably, our work demonstrates the feasibility of MDI-QDS for practical applications.Comment: 5 pages, 1 figure, 2 tables, supplemental materials included as ancillary fil

Experimental Side-Channel-Free Quantum Key Distribution

Quantum key distribution can provide unconditionally secure key exchange for remote users in theory. In practice, however, in most quantum key distribution systems, quantum hackers might steal the secure keys by listening to the side channels in the source, such as the photon frequency spectrum, emission time, propagation direction, spatial angular momentum, and so on. It is hard to prevent such kinds of attacks because side channels may exist in any of the encoding space whether the designers take care of or not. Here we report an experimental realization of a side-channel-free quantum key distribution protocol which is not only measurement-device-independent, but also immune to all side-channel attacks in the source. We achieve a secure key rate of 4.80e-7 per pulse through 50 km fiber spools.Comment: 23 pages, 5 figure

Field demonstration of distributed quantum sensing without post-selection

Distributed quantum sensing can provide quantum-enhanced sensitivity beyond the shot-noise limit (SNL) for sensing spatially distributed parameters. To date, distributed quantum sensing experiments have been mostly accomplished in laboratory environments without a real space separation for the sensors. In addition, the post-selection is normally assumed to demonstrate the sensitivity advantage over the SNL. Here, we demonstrate distributed quantum sensing in field and show the unconditional violation (without post-selection) of SNL up to 0.916 dB for the field distance of 240 m. The achievement is based on a loophole free Bell test setup with entangled photon pairs at the averaged heralding efficiency of 73.88%. Moreover, to test quantum sensing in real life, we demonstrate the experiment for long distances (with 10-km fiber) together with the sensing of a completely random and unknown parameter. The results represent an important step towards a practical quantum sensing network for widespread applications.Comment: 8 pages, 5 figure