On nonlinearity in hydrodynamic response to the initial geometry in relativistic heavy-ion collisions

In the context of event-by-event hydrodynamic description, we analyze the implications of two models characterized by distinct initial conditions. The initial energy density of the first model adopts a Gaussian-type distribution, while those of the second one are features by high energy peripheral tubes. We calibrate the initial conditions of both models so that their initial probability distribution of eccentricity are mostly identical. Subsequently, the resultant scaled probability distributions of collective flow and the correlations between flow harmonic and eccentricity coefficients are investigated. Besides, the calculations are carried out for particle correlations regarding the symmetric cumulant, mixed harmonics, and nonlinear response coefficients. Although the resultant two-particle correlations possess similar shapes, numerical calculations indicate a subtle difference between the two models. To be specific, the difference resides in more detailed observables such as the probability distributions of elliptic flow as well as Pearson correlation coefficient regarding higher-order harmonics. We discuss several essential aspects concerning the linearity and nonlinearity between initial eccentricities and final state anisotropies. Further implications are addressed.Comment: 17 pages, 5 figure

Dynamical transitions in scalarization and descalarization through black hole accretion

We present the first fully nonlinear study on the accretion of scalar fields onto a seed black hole in anti-de Sitter spacetime in Einstein-Maxwell-scalar theory. Intrinsic critical phenomena in the dynamical transition between the bald and scalarized black holes are disclosed. In scalarizations, the transition is discontinuous and a metastable black hole acts as an attractor at the threshold. We construct a new physical mechanism to dynamically descalarize an isolated scalarized black hole. The first results on critical phenomena in descalarizations are revealed. The dynamical descalarizations can be either discontinuous or continuous at the threshold, distinguished by whether or not an attractor appears

Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: Pro-survival role of Ambra1

Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells. However, whether Ambra1 plays an important role in the autophagy pathway in colorectal cancer cells is unknown. In this study, we hypothesized that Ambra1 is an important regulator of autophagy and apoptosis in CRC cell lines. To test this hypothesis, we confirmed autophagic activity in serum-starved SW620 CRC cells by assessing endogenous microtubule-associated protein 1 light chain 3 (LC3) localization, the presence of autophagosomes (transmission electron microscopy) and LC3 protein levels (Western blotting). Ambra1 expression was detected by Western blot in SW620 cells treated with staurosporine or etoposide. Calpain and caspase inhibitors were employed to verify whether calpains and caspases were responsible for Ambra1 cleavage. To examine the role of Ambra1 in apoptosis, Ambra1 knockdown cells were treated with staurosporine and etoposide. Cell apoptosis and viability were measured by annexin-V and PI staining and MTT assays. We determined that serum deprivation-induced autophagy was associated with Ambra1 upregulation in colorectal cancer cell lines. Ambra1 expression decreased during staurosporine- or etoposide-induced apoptosis. Calpains and caspases may be responsible for Ambra1 degradation. When Ambra1 expression was reduced by siRNA, SW620 cells were more sensitive to staurosporine- or etoposide-induced apoptosis. In addition, starvation-induced autophagy decreased. Finally, Co-immunoprecipitation of Ambra1 and Beclin1 demonstrated that Ambra1 and Beclin1 interact in serum-starved or rapamycin-treated SW620 cells, suggesting that Ambra1 regulates autophagy in CRC cells by interacting with Beclin1. In conclusion, Ambra1 is a crucial regulator of autophagy and apoptosis in CRC cells that maintains the balance between autophagy and apoptosis

Effects of Krill Oil on serum lipids of hyperlipidemic rats and human SW480 cells

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