Bis(acetato-κ2 O,O′)bis­(2-amino­pyridine-κN)nickel(II)

The title complex, [Ni(C2H3O2)2(C5H6N2)2], has a distorted octa­hedral geometry around the Ni atom. Inter­molecular and intra­molecular N—H⋯O hydrogen bonds exist in the crystal structure

E2F1-EP300 co-activator complex potentiates immune escape in nasopharyngeal carcinoma through the mediation of MELK

Background. Nasopharyngeal carcinoma (NPC) is characterized by a highly suppressive microenvironment that protects tumor cells against immune attack and facilitates tumor progression. MELK is upregulated in various tumors, whereas its function in the immune escape remains largely unknown. In this study, we investigated the role of MELK during immune escape in NPC. Methods. Differentially expressed genes were filtered using GEO datasets and PPI network analysis. NPC cell colony formation and motility were examined, and the impact of CD8+ T cells on NPC cells was evaluated. A xenograft model was constructed to detect the growth of tumor cells and the T-cell phenotype of tumor infiltration. ChIP-qPCR and dual-luciferase assays were used to verify the transcriptional regulation of MELK by EP300/E2F1. Findings. MELK was overexpressed in NPC, and sh-MELK suppressed the clonogenic ability, migration, and invasion of NPC cells and promoted the killing effects of CD8+ T cells. These in vitro findings were reproduced in vivo. EP300 synergized E2F1 to regulate the transcription of MELK in NPC cells. Loss of EP300 or E2F1 reverted the malignant phenotype of NPC cells and promoted the immune effect of CD8+ T cells. MELK further suppressed the immune effect of CD8+ T cells in the presence of sh-E2F1. Interpretation. EP300 coordinated with E2F1 to promote the transcription of MELK which promoted the growth of NPC cells and repressed the killing effect of CD8+ T cells. Blockage of MELK may be a potential way to suppress the immune escape of NPC cells

Simulation and Experimental Study on Load-bearing Deformation Characteristics of 11R22.5 Vehicle Retreaded Tire

The finite element bearing deformation simulation was implemented on 11.00R22.5 retreaded tires by ANSYS software in the paper in order to further clarify the bearing deformation characteristics of retreaded tires and improve the performance of retreaded tires effectively. The characteristic laws of bearing radial deformation and bearing lateral deformation of retreaded tire and new tires of the same model under different working conditions were obtained through load deformation tests. The radial deformation calculation results, simulation results and measured results of retreaded tires were comparatively analyzed. The calculation formula of bearing radial deformation of retreaded tires was proposed based on the linear regression principle. The difference of bearing deformation characteristics and ground area characteristics of retreaded tires and new tires were comparatively analyzed. The results showed that the radial and lateral deformation of retreaded tires and new tires is increased with the increase of radial load when the tire pressure was constant, and the increase trend is approximately linear. The radial stiffness of retreaded tires is similar to that of new tires under certain tire pressure and low load. The radial stiffness of retreaded tires is larger than that of new tires, and the stiffness difference is increased with the increasing of load under constant tire pressure and high load. Rubber aging phenomenon in retreaded tire carcass have an impact on the bearing deformation characteristics of retreaded tires, thereby producing great impact on the remaining service life of retreaded tires

N-[4-(Dimethyl­amino)benzyl­idene]-4-ethoxy­aniline

In the title compound, C17H20N2O, the mol­ecular core is planar, with a central C—N=C—C torsion angle of −179.3 (3)°. However, the overall geometry is not planar, with a dihedral angle of 61.96 (1)° between the two benzene rings, which adopt a trans configuration with respect to the C=N bond [1.269 (4) Å]. The bond lengths and angles are within normal range

Aqua­bis(o-vanillinato-κ2 O,O′)nickel(II)

The NiII atom in the title complex, aqua­bis(2-formyl-6-meth­oxy­phenolato-κ2 O,O′)nickel(II), [Ni(C8H7O3)2(H2O)], is five-coordinated by four O atoms from two o-vanillinate ligands and one water mol­ecule in a slightly distorted square-pyramidal geometry (τ = 0.06). In the crystal structure, the mol­ecules are linked into dimers by inter­molecular O—H⋯O hydrogen bonds

Dual-Stage Approach Toward Hyperspectral Image Super-Resolution

Hyperspectral image produces high spectral resolution at the sacrifice of spatial resolution. Without reducing the spectral resolution, improving the resolution in the spatial domain is a very challenging problem. Motivated by the discovery that hyperspectral image exhibits high similarity between adjacent bands in a large spectral range, in this paper, we explore a new structure for hyperspectral image super-resolution (DualSR), leading to a dual-stage design, i.e., coarse stage and fine stage. In coarse stage, five bands with high similarity in a certain spectral range are divided into three groups, and the current band is guided to study the potential knowledge. Under the action of alternative spectral fusion mechanism, the coarse SR image is super-resolved in band-by-band. In order to build model from a global perspective, an enhanced back-projection method via spectral angle constraint is developed in fine stage to learn the content of spatial-spectral consistency, dramatically improving the performance gain. Extensive experiments demonstrate the effectiveness of the proposed coarse stage and fine stage. Besides, our network produces state-of-the-art results against existing works in terms of spatial reconstruction and spectral fidelity