3,742 research outputs found
Quantum memory and non-demolition measurement of single phonon state with nitrogen-vacancy centers ensemble
In diamond, the mechanical vibration induced strain can lead to interaction
between the mechanical mode and the nitrogen-vecancy (NV) centers. In this
work, we propose to utilize the strain induced coupling for the quantum
non-demolition (QND) single phonon measurement and memory in diamond. The
single phonon in a diamond mechanical resonator can be perfectly absorbed and
emitted by the NV centers ensemble (NVE) with adiabatically tuning the
microwave driving. An optical laser drives the NVE to the excited states, which
have much larger coupling strength to the mechanical mode. By adiabatically
eliminating the excited states under large detuning limit, the effective
coupling between the mechanical mode and the NVE can be used for QND
measurement of the single phonon state. Under realistic experimental
conditions, we numerically simulate the scheme. It is found that the fidelity
of the absorbing and emitting process can reach a much high value. The overlap
between the input and the output phonon shapes can reach .Comment: 7 pages, 3 figure
Efficacy of Gene Therapy Is Dependent on Disease Progression in Dystrophic Mice with Mutations in the FKRP Gene
Loss-of-function mutations in the Fukutin-related protein ( ) gene cause limb-girdle muscular dystrophy type 2I (LGMD2I) and other forms of congenital muscular dystrophy-dystroglycanopathy that are associated with glycosylation defects in the α-dystroglycan (α-DG) protein. Systemic administration of a single dose of recombinant adeno-associated virus serotype 9 (AAV9) vector expressing human to a mouse model of LGMD2I at various stages of disease progression was evaluated. The results demonstrate rescue of functional glycosylation of α-DG and muscle function, along with improvements in muscle structure at all disease stages versus age-matched untreated cohorts. Nevertheless, mice treated in the latter stages of disease progression revealed a decrease in beneficial effects of the treatment. The results provide a proof of concept for future clinical trials in patients with -related muscular dystrophy and demonstrate that AAV-mediated gene therapy can potentially benefit patients at all stages of disease progression, but earlier intervention would be highly preferred
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