The Immunomodulatory Role of Probiotics

Probiotics are particularly beneficial living microorganisms that help improve human health. Although probiotics have long been used as nutritional supplements in various cultures around the world, new research has investigated their antimicrobial and immune boosting effects in individuals. Lactobacillus and Bifidobacterium are popular probiotics used worldwide that benefit human health by acting as antibacterial, antiviral, and antifungal agents, reducing pathogen binding to the host receptor and thus capturing pathogenic microorganisms. Probiotics have been shown to be beneficial in a variety of bacterial and viral diseases worldwide. The regulation of the host’s immune response is one of the most important mechanisms of probiotic action. Immunomodulatory effects of probiotic-derived compounds have been characterized using genomic and proteomic analysis. These compounds have the ability to regulate and initiate mucosal immunity against various diseases. Probiotics produce many bactericidal compounds, which inhibit the growth of pathogenic microorganisms and their toxins, promoting the sustainability and structural integrity of enterocytes. This chapter focused on recent scientific research findings that help us better understand how probiotics regulate the host immune response and how they can be used to prevent and treat disease and there beneficial role to improve the health status of individuals

Tehrik-e-Taliban Pakistan: An attempt to deconstruct the umbrella organization and the reasons for its growth in Pakistan's north-west

The present report aims to describe the concept of the militant umbrella organization Tehrik-e-Taliban Pakistan (TTP) by looking at the organisational structure, background and ideology of the group. Tactics and recruitment strategies are also discussed, along with the various financial sources that have helped sustain the TTP. Finally, the reasons for the spread and rise of the TTP are analysed

Pakistan's future policy towards Afghanistan: A look at strategic depth, militant movements and the role of India and the US

What factors are likely to govern the course of Pakistan's future policy vis-à-vis Afghanistan? This question has increasing relevance for regional security, especially in the light of the imminent endgame in Afghanistan and of the ongoing dialogue with the Taliban. This report probes the implications of the volatile US-Pakistan relationship and of Indo-Pak rivalry in the Af-Pak war theatre, in particular for Pakistan's reliance on militant extremist groups to secure and further its strategic interests. Developments pertaining to the role and engagement of the United States in the region and Indian ties to Afghanistan and the US affect Pakistan's perceived power status in the Indian subcontinent. The extent to which Pakistani interests are met in the process and outcome of brokering a deal with the Taliban is an additional determinant of whether Pakistan will continue with, or veer from, the status quo

Analysis of Flood Damage Assessment through WorldView-2, Quick Bird and Multispectral Satellite Imagery in Southern Punjab, Pakistan

Pakistan has faced numerous natural disasters like floods, earthquakes, landslides and environmental degradation which severely affects the Pakistan’s economy and results in various problems like causalities, diseases, water stress and severe damages (e.g., houses, public infrastructure and agricultural land erosion). There is a lack of systematic approaches to analyze pre and post damage assessment for estimation of exact loses and the total cost for rehabilitation of damaged infrastructure in an efficient way. There exist a variety of mechanisms but GIS based flood mapping is considered the most efficient to manage the flood situation. This study is focused on evaluation of flood affected areas especially in Punjab using WorldView-2, 8-band multi-spectral imagery by applying Remote Sensing (RS) and GIS techniques. The research area is comprised of Kot Addu and Muzaffargarh Districts in Punjab province of Pakistan that faced a catastrophic super flood of 2010. The WorldView-2, Quick Bird and multispectral satellite imagery are capable of making better decisions and assessment of flood effected area accurately. RS and GIS techniques can achieve the objectives and significant analyses through visual interpretations. These techniques are also used to identify the flood affected regions. The study site was examined by applying supervised classification on the basis of the training areas which were obtained during the field surveys in the study site. Supervised classification determines that 16900.96 Hectors of agriculture land was damaged while Sparse Riverine Forest had the area 44.52 hectors. The damaged built-up area was 1805.78 Hectors. RS and GIS techniques are efficient for flood mapping. Full Tex