A WENO Algorithm of the Temperature and Ionization Profiles around a Point Source

We develop a numerical solver for radiative transfer problems based on the weighted essentially nonoscillatory (WENO) scheme modified with anti-diffusive flux corrections, in order to solve the temperature and ionization profiles around a point source of photons in the reionization epoch. Algorithms for such simulation must be able to handle the following two features: 1. the sharp profiles of ionization and temperature at the ionizing front (I-front) and the heating front (T-front), and 2. the fraction of neutral hydrogen within the ionized sphere is extremely small due to the stiffness of the rate equations of atom processes. The WENO scheme can properly handle these two features, as it has been shown to have high order of accuracy and good convergence in capturing discontinuities and complicated structures in fluid as well as to be significantly superior over piecewise smooth solutions containing discontinuities. With this algorithm, we show the time-dependence of the preheated shell around a UV photon source. In the first stage the I-front and T-front are coincident, and propagate with almost the speed of light. In later stage, when the frequency spectrum of UV photons is hardened, the speeds of propagation of the ionizing and heating fronts are both significantly less than the speed of light, and the heating front is always beyond the ionizing front. In the spherical shell between the I- and T-fronts, the IGM is heated, while atoms keep almost neutral. The time scale of the preheated shell evolution is dependent on the intensity of the photon source. We also find that the details of the pre-heated shell and the distribution of neutral hydrogen remained in the ionized sphere are actually sensitive to the parameters used. The WENO algorithm can provide stable and robust solutions to study these details.Comment: 24 pages, 7 figures, accepted in New Astronom

Decomposition of Multi-Objective Evolutionary Algorithm based on Estimation of Distribution

Abstract: Decomposition of multi-objective evolutionary algorithm has better distribution, but the number of groups will increase dramatically as the target number increases, seriously affecting the efficiency of the algorithm. This paper presents a decomposition of multi-objective evolutionary algorithm based on estimation of distribution, the basic idea of which is: to decompose multiple objectives into several single objective first and then to establish the probability model for every single objective based on the idea of estimation of distribution, generating the solution by sampling. Numerical analysis and experiments show that the solution of the new algorithm not only has better diversity and uniformity, but also the computational complexity of the algorithm is significantly lower than the decomposition of multi-objective evolutionary algorithm, especially for optimization of three goals

A WENO Algorithm for the Radiative Transfer and Ionized Sphere at Reionization

We show that the algorithm based on the weighted essentially nonoscillatory (WENO) scheme with anti-diffusive flux corrections can be used as a solver of the radiative transfer equations. This algorithm is highly stable and robust for solving problems with both discontinuities and smooth solution structures. We test this code with the ionized sphere around point sources. It shows that the WENO scheme can reveal the discontinuity of the radiative or ionizing fronts as well as the evolution of photon frequency spectrum with high accuracy on coarse meshes and for a very wide parameter space. This method would be useful to study the details of the ionized patch given by individual source in the epoch of reionization. We demonstrate this method by calculating the evolution of the ionized sphere around point sources in physical and frequency spaces. It shows that the profile of the fraction of neutral hydrogen and the ionized radius are sensitively dependent on the intensity of the source.Comment: Elsart Latex file, 20 pages, 8 figures included, accepted for publication in New Astronom

21 cm Signals from Early Ionizing Sources

We investigate the 21 cm signals from the UV ionizing sources in the reionization epoch. The formation and evolution of 21 cm emission and absorption regions depend essentially on the kinetics of photons in the physical and frequency spaces. To solve the radiative transfer equation, we use the WENO algorithm, which is effective to capture the sharp ionization profile and the cut-off at the front of light $(r=ct)$ and to handle the small fraction of neutral hydrogen and helium in the ionized sphere. We show that a spherical shell of 21 cm emission and absorption will develop around a point source once the speed of the ionization front (I-front) is significantly lower than the speed of light. The 21 cm shell extends from the I-front to the front of light; its inner part is the emission region and its outer part is the absorption region. The 21 cm emission region depends strongly on the intensity, frequency-spectrum and life-time of the UV ionizing source. For a source of short life-time, no 21 cm emission region can be formed if the source dies out before the I-front speed is significantly lower than the speed of light. Yet, a 21 cm absorption region can form and develop even after the emission of the source ceases.Comment: 25 pages, 9 figures, accepted by Ap

Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo

<p>Abstract</p> <p>Background</p> <p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed oncolytic adenoviral vector and investigated its antitumor effect both in vitro and in vivo.</p> <p>Methods</p> <p>Since the up-regulated expression of human telomerase reverse transcriptase (hTERT) is a hallmark of alltypes of NSCLC, we chose hTERT promoter to transcriptionally control E1A gene expression to obtain adenoviral replication in NSCLC. In order to further enhance anti-tumor effect of this oncolytic adenoviral vector, we inserted a 'suicide gene' i.e. Herpes Simplex Virus Thymidine Kinase (HSV-TK) into oncolytic adenoviral vector to engineer a novel armed oncolytic adenoviral vector 'Ad.hTERT-E1A-TK'.</p> <p>Results</p> <p>Ad.hTERT-E1A-TK efficiently killed different types of tumor cells including two types of NSCLC cells <it>in vitro</it>, causing no damage to normal primary fibroblasts. Furthermore, Ad.hTERT-E1A-TK infection combined with administration of prodrug gancyclovir (GCV) resulted in more potent cytotoxicity on NSCLC cells, and synergistically suppressed human NSCLC tumor growth in nude mice.</p> <p>Conclusion</p> <p>The results from this study showed that Ad.hTERT-E1A-TK/GCV could be a potent but safe anti-tumor strategy for NSCLC biotherapy.</p

The Photometric System of Tsinghua-NAOC 80-cm Telescope at NAOC Xinglong Observatory

Tsinghua-NAOC (National Astronomical Observatories of China) Telescope (hereafter, TNT) is an 80-cm Cassegrain reflecting telescope located at Xinglong bservatory of NAOC, with main scientific goals of monitoring various transients in the universe such as supernovae, gamma-ray bursts, novae, variable stars, and active galactic nuclei. We present in this paper a systematic test and analysis of the photometric performance of this telescope. Based on the calibration observations on twelve photometric nights, spanning the period from year 2004 to year 2012, we derived an accurate transformation relationship between the instrumental $ubvri$ magnitudes and standard Johnson $UBV$ and Cousins $RI$ magnitudes. In particular, the color terms and the extinction coefficients of different passbands are well determined. With these data, we also obtained the limiting magnitudes and the photometric precision of TNT. It is worthwhile to point out that the sky background at Xinglong Observatory may become gradually worse over the period from year 2005 to year 2012 (e.g., $\sim$21.4 mag vs. $\sim$20.1 mag in the V band).Comment: 12 pages,9 figures, accepted by RA