26 research outputs found
Remarks on Hawking radiation as tunneling from the BTZ black holes
Hawking radiation viewed as a semiclassical tunneling process from the event
horizon of the (2 + 1)-dimensional rotating BTZ black hole is carefully
reexamined by taking into account not only the energy conservation but also the
conservation of angular momentum when the effect of the emitted particle's
self-gravitation is incorporated. In contrast to previous analysis of this
issue in the literature, our result obtained here fits well to the
Kraus-Parikh-Wilczek's universal conclusion without any modification to the
Bekenstein-Hawking area-entropy formulae of the BTZ black hole.Comment: 12pages, no figure, use JHEP3.cls. Version better than published one
in JHE
Pulsed electromagnetic fields promote bone formation by activating the sACâcAMPâPKAâCREB signaling pathway
The application of pulsed electromagnetic fields (PEMFs) in the prevention and treatment of osteoporosis has long been an area of interest. However, the clinical application of PEMFs remains limited because of the poor understanding of the PEMF action mechanism. Here, we report that PEMFs promote bone formation by activating soluble adenylyl cyclase (sAC), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and cAMP response element-binding protein (CREB) signaling pathways. First, it was found that 50âHz 0.6 millitesla (mT) PEMFs promoted osteogenic differentiation of rat calvarial osteoblasts (ROBs), and that PEMFs activated cAMP-PKA-CREB signaling by increasing intracellular cAMP levels, facilitating phosphorylation of PKA and CREB, and inducing nuclear translocation of phosphorylated (p)-CREB. Blocking the signaling by adenylate cyclase (AC) and PKA inhibitors both abolished the osteogenic effect of PEMFs. Second, expression of sAC isoform was found to be increased significantly by PEMF treatment. Blocking sAC using sAC-specific inhibitor KH7 dramatically inhibited the osteogenic differentiation of ROBs. Finally, the peak bone mass of growing rats was significantly increased after 2 months of PEMF treatment with 90âmin/day. The serum cAMP content, p-PKA, and p-CREB as well as the sAC protein expression levels were all increased significantly in femurs of treated rats. The current study indicated that PEMFs promote bone formation in vitro and in vivo by activating sAC-cAMP-PKA-CREB signaling pathway of osteoblasts directly or indirectly.YuanâYuan Wang, XiuâYing Pu, WenâGui Shi, QingâQing Fang, XinâRu Chen,
HuiâRong Xi, YuâHai Gao, Jian Zhou, Cory J. Xian, KeâMing Che