向精神薬服用患者の突然死症例におけるカリウムイオンチャネルに関する分子生物学的解析：QT延長症候群関連遺伝子の多型が危険因子となり得るか？

Psychotropic drugs can pose the risk of acquired long QT syndrome (LQTS). Unexpected autopsy-negative sudden death in patients taking psychotropic drugs may be associated with prolonged QT intervals and life-threatening arrhythmias. We analyzed genes that encode for cardiac ion channels and potentially associated with LQTS, examining specifically the potassium channel genes KCNQ1 and KCNH2 in 10 cases of sudden death involving patients administered psychotropic medication in which autopsy findings identified no clear cause of death. We amplified and sequenced all exons of KCNQ1 and KCNH2, identifying G643S, missense polymorphism in KCNQ1, in 6 of the 10 cases. A study analysis indicated that only 11% of 381 healthy Japanese individuals carry this polymorphism. Reports of previous functional analyses indicate that the G643S polymorphism in the KCNQ1 potassium channel protein causes mild IKs channel dysfunction. Our present study suggests that administering psychotropic drug therapy to individuals carrying the G643S polymorphism may heighten the risk of prolonged QT intervals and life-threatening arrhythmias. Thus, screening for the G643S polymorphism before prescribing psychotropic drugs may help reduce the risk of unexpected sudden death2013博士（歯学）松本歯科大

Abnormalities in liver enzymes during simultaneous therapy with intraconazole and amphotericin B in leukaemic patients

International audienc

Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study

International audienceMany elderly patients are routinely exposed to drugs that may prolong the cardiac QT interval and cause Torsades de pointes (TdP). However, predictors of TdP in patients with drug-associated long QT syndrome (LQTS) are not fully understood, especially in the geriatric population. The objective of this study was to identify risk factors of TdP in elderly patients with drug-associated LQTS

Abnormalities in liver enzymes during simultaneous therapy with intraconazole and amphotericin B in leukaemic patients

International audienc

Experimental Intracameral Injection of Vancomycin Microparticles in Rabbits

Journal of Ecohydrology & Hydrobiology, 2017; 17 : 33–45The values of watershed services from watersheds has for many years been neglected, underestimated and not factored in land use decisions for sustainable management. Sustainable management of watersheds and environmental friendly economic activities are vital for sustained water flow, steady supply of ecosystem services for societal needs and enhancement of aquatic vegetation and animal species. The problem of the failure to capture actual values of ecosystem services from watersheds and incorporate them in the national income accounting is profound in developing countries which are characterized with constrained budget for financing conservation programs. To resolve this problem attention has moved to market based instruments such as payment for watershed services (PWS). However, the approach to elicit the necessary information for PWS to kick off is still lacking. Furthermore, Ecohydrology, defined as an integrative sustainability science using the interactions between hydrology, biota and natural processes as management tools to reinforce ecosystem services on a broad range of landscapes (Zalewski, 2015) is a basis for the development and application of market-based approaches in watershed conservation. This study investigated small holder farmers’ willingness to pay (WTP) for watershed services in Pangani River Basin. A contingent valuation method was employed to elicit the willingness to pay for watershed conservation. A probit model was used to determine respondents’ response to WTP and factors conditioning the maximum amount they are WTP. Findings indicates that majority of respondents are willing to pay for watershed services. Similarly, result reveals that marital status, household size and distance from the water source positively influence smallholder farmers’ WTP and the maximum amount to be paid. Equally important occupation, household size, income from irrigation, and amount paid for irrigation were found to negatively influencing smallholder farmers’ WTP. The result also revealed that education level, total land size and yield from irrigated farm plot positively influence smallholder farmers’ WTP. These results therefore, indicate that establishment of PWS is feasible

Evaluation de la tolérance clinique et biologique de l’intraconazole chez des patients présentant des taux sériques élevés

International audienc

Evaluation de la tolérance clinique et biologique de l’intraconazole chez des patients présentant des taux sériques élevés

International audienc

Hepatic disorders during the simultaneous therapy with intraconazole and amphotericin B in leukemic patients

International audienc

Hepatic disorders during the simultaneous therapy with intraconazole and amphotericin B in leukemic patients

International audienc