The immunologic effect of early intravenous two and four gram bolus dosing of tranexamic acid compared to placebo in patients with severe traumatic bleeding (TAMPITI): A randomized, double-blind, placebo-controlled, single-center trial

Background: The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods: This was a single center, double-blinded, randomized controlled trial (RCT) comparing placebo to a 2 g or 4 g intravenous TXA bolus dose in trauma patients with severe injury. Fifty patients were randomized into each study group. The primary outcome was a reduction in monocyte activation as measured by human leukocyte antigen-DR isotype (HLA-DR) expression on monocytes 72 h after TXA administration. Secondary outcomes included kinetic assessment of immune and hemostatic phenotypes within the 72 h window post-TXA administration. Results: The trial occurred between March 2016 and September 2017, when data collection ended. 149 patients were analyzed (placebo, Conclusion: In trauma patients with severe injury, 4 g intravenous bolus dosing of TXA has minimal immunomodulatory effects with respect to leukocyte phenotypes and circulating cytokine levels. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02535949

Severe traumatic injury during long duration spaceflight: Light years beyond ATLS

Traumatic injury strikes unexpectedly among the healthiest members of the human population, and has been an inevitable companion of exploration throughout history. In space flight beyond the Earth's orbit, NASA considers trauma to be the highest level of concern regarding the probable incidence versus impact on mission and health. Because of limited resources, medical care will have to focus on the conditions most likely to occur, as well as those with the most significant impact on the crew and mission. Although the relative risk of disabling injuries is significantly higher than traumatic deaths on earth, either issue would have catastrophic implications during space flight. As a result this review focuses on serious life-threatening injuries during space flight as determined by a NASA consensus conference attended by experts in all aspects of injury and space flight

Supporting and Recognizing Excellence in Teaching: STP at 75

© The Author(s) 2020. Established in 1945 as Division 2, one of the original divisions of the American Psychological Association, the Society for the Teaching of Psychology (STP) celebrates its 75th anniversary in 2020. On the occasion of STP’s 50th anniversary, Wight and Davis published a history of the Division’s first 50 years. Using that history, we summarize STP’s first 50 years and then focus on developments and changes during the last 25 years. We believe that STP has experienced greater change and growth in the last 25 years than it did in the first 50 years

Desired Outcomes of an Undergraduate Education in Psychology from Departmental, Student, and Societal Perspectives

What are the desired outcomes of an undergraduate education in psychology? It is vital to identify the desired outcomes that benefit departments, students, and society, because the pursuit of these goals helps psychology educators achieve the best possible learning experience for their students. We purposely take a different approach to what might be expected of an outcomes chapter in a review of undergraduate psychology education. We address methods that departments and educational institutions use to assess the outcomes of psychology education from the standpoint of departmental performance and student achievement. We identify goals of the undergraduate experience held by psychology faculty, employers, and students and we examine current indicators of postbaccalaureate success through educational outcomes. We then place our students\u27 achievements in a broader context of societal demands and global expectations. We conclude this chapter with specific recommendations and a call to action