New isoflavones from Iris kashmiriana

Phytochemical investigation of the rhizomes of Iris kashmiriana (Iridaceae) led to the isolation of three isoflavones characterized by 1D and 2D NMR, IR, UV, and MS as 4 0 -hydroxy-8-methoxy-6,7-methylenedioxyisoflavone (isonigricin, 1), 5,6-dihydroxy-4 0 ,7-dimethoxyisoflavone (isoirisolidone, 2), and 5,7-dihydroxy-4 0 ,6-dimethoxyisoflavone (irisolidone, 3). Compound 1 is a new isoflavone, while 2 is reported for the first time from a natural source

Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential

Regio-/stereoselective Michael addition to ring A of withaferin-A was performed using an optimized reaction procedure to synthesise a library of 2,3-dihydro,3-�-substituted withaferin-A derivatives. The analogues thus obtained were evaluated for in vitro cytotoxicity against various human cancer cell lines.3-Azido analogue exhibited 35-fold increase (IC50 = 0.02–1.9 �M) in cytotoxicity against almost the entire cell lines tested when compared to the parent molecule. However, further modifications of 3-azido analogue with various alkynes under Husigen’s cycloaddition conditions generated a variety of triazole derivatives with reduced cytotoxicity

Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-a. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments