High performance astrophysics computing

The application of high end computing to astrophysical problems, mainly in the galactic environment, is under development since many years at the Dep. of Physics of Sapienza Univ. of Roma. The main scientific topic is the physics of self gravitating systems, whose specific subtopics are: i) celestial mechanics and interplanetary probe transfers in the solar system; ii) dynamics of globular clusters and of globular cluster systems in their parent galaxies; iii) nuclear clusters formation and evolution; iv) massive black hole formation and evolution; v) young star cluster early evolution. In this poster we describe the software and hardware computational resources available in our group and how we are developing both software and hardware to reach the scientific aims above itemized.Comment: 2 pages paper presented at the Conference "Advances in Computational Astrophysics: methods, tools and outcomes", to be published in the ASP Conference Series, 2012, vol. 453, R. Capuzzo-Dolcetta, M. Limongi and A. Tornambe' ed

On the asymptotic behaviour of solutions to the fractional porous medium equation with variable density

We are concerned with the long time behaviour of solutions to the fractional porous medium equation with a variable spatial density. We prove that if the density decays slowly at infinity, then the solution approaches the Barenblatt-type solution of a proper singular fractional problem. If, on the contrary, the density decays rapidly at infinity, we show that the minimal solution multiplied by a suitable power of the time variable converges to the minimal solution of a certain fractional sublinear elliptic equation.Comment: To appear in DCDS-

Non \ue8 pi\uf9 quella di una volta. La mafia e le attivit\ue0 estorsive in Sicilia

Il volume presenta i risultati di una ricerca volta alla descrizione dei fenomeni estorsivi e della loro intensit\ue0 in Sicilia, raccontando, sulla base di appositi parametri oggettivi e di valutazioni soggettive degli esponenti del mondo delle associazioni e delle forze dell\u2019ordine, le aree pi\uf9 esposte, quelle meno esposte, quelle dove i fenomeni hanno una rilevanza residuale, in una fase in cui i sodalizi mafiosi sono sempre pi\uf9 pressati dall\u2019azione di contrasto. Per raggiungere questo obiettivo ci si \ue8 avvalsi di strumenti qualitativi e dati quantitativi, approfondendo l\u2019analisi delle trasformazioni delle condotte estorsive durante la crisi, concentrandosi in modo specifico su casi emersi nell\u2019ambito di recenti inchieste giudiziarie. Il libro ricostruisce anche la prospettiva e le difficolt\ue0 di alcuni imprenditori siciliani che, dopo aver pagato il pizzo, hanno scelto di denunciare i propri estorsori e di collaborare con le istituzioni

Exploring antecedents of innovations for small- and medium-sized enterprises' environmental sustainability: An interpretative framework

The need to pursue sustainable development has become a central topic in Western countries due to citizens' greater sensitivity to improving environmental and social conditions. Companies can reach this objective more easily through green innovations, which are now considered a strategic opportunity that simultaneously allows for adherence to sustainable development criteria and the pursuit of competitive advantages. Scholars have identified the determinants that encourage companies to adopt green innovations, but the outcomes of their investigations thus far have often been ambiguous and contradictory. Our paper proposes an interpretative framework for addressing such inconsistencies. Using the partial least squares structural equation modelling (PLS-SEM) methodology, we validate this framework on a sample of small- and medium-sized enterprises (SMEs) and show that SMEs' choices are influenced by cultural elements and stimulated by the prospect of obtaining economic advantages over competitors. SMEs also pay close attention to stakeholder solicitations, while public administration does not affect their eco-innovating choices. The results have policy implications for executives and insiders

Banks\u2019 leverage behaviour in a two-agent New Keynesian model

In a NK model with two types of rational agents, savers and capitalists, and non- maximizing banks, \u85nancial shocks do a\ua4ect the macroeconomic dynamics depending on banks\u92behaviour as for their leverage ratio. We \u85rst show that the level of banks\u92 leverage - which may be imposed by banks regulation - a\ua4ects the steady state level of output, employment and consumption, as might be expected in a non-Modigliani- Miller world. Di\ua4erent banks\u92 behaviour after a shock has widely di\ua4erent e\ua4ects on the macroeconomic dynamics: passive leverage results to be shock absorbing and capable of neutralizing an initial \u85nancial shock, whilst procyclical behaviour implies higher and more persistent instability and distributive e\ua4ects than the constant lever- age behaviour. Finally, we show that the interaction of procyclical leverage with hysteresis in output and employment stregthens the persistence of financial shocks

On the stability of solutions of semilinear elliptic equations with Robin boundary conditions on Riemannian manifolds

We investigate existence and nonexistence of stationary stable nonconstant solutions, i.e. patterns, of semilinear parabolic problems in bounded domains of Riemannian manifolds satisfying Robin boundary conditions. These problems arise in several models in applications, in particular in Mathematical Biology. We point out the role both of the nonlinearity and of geometric objects such as the Ricci curvature of the manifold, the second fundamental form of the boundary of the domain and its mean curvature. Special attention is devoted to surfaces of revolution and to spherically symmetric manifolds, where we prove refined results

New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence

Decapod crustaceans associated with an artificial reef (Adriatic Sea)

The aim of this study is to increase the knowledge on the distribution of decapod crustaceans associated with an artificial reef positioned on sandy-mud bottoms in the central Adriatic Sea. The reef is constituted of concrete modules assembled in pyramids and concrete poles. Hard and soft bottom samples were collected from 2001, just after reef construction, to 2005 (4 surveys per year). Regarding the soft seabed, three sites close to a pyramid, three inside the reef area at a distance of 10-15 m from the structures, and three 200 m outside the reef (control sites) were randomly sampled during each survey. At the same time, three pyramids (vertical and horizontal walls) and three poles were also investigated. After taxonomical analysis, decapod crustaceans were analysed using abundance and species richness. Sites and years were compared using a balanced, fixed effect, 2-way ANOVA and PERMANOVA. In addition, SIMPER analysis was performed to identify those species typifying each community inhabiting both the soft bottom and the artificial substrates. The results showed that the artificial reef induced an increase in both abundance and diversity of the decapods of the natural habitat. In fact, man-made substrates may offer new available space for biological colonization and allow the settlement of new species usually living on hard bottoms, thus increasing the complexity of the original benthic communities

Treatment with PCSK9 Inhibitor Evolocumab Improves Vascular Oxidative Stress and Arterial Stiffness in Hypercholesterolemic Patients with High Cardiovascular Risk

Atherosclerosis and atherosclerotic-related cardiovascular diseases (ASCVD) are characterized by high serum levels of low-density lipoprotein cholesterol (LDL-C) that can promote the generation of reactive oxygen species (ROS). To answer the need for better LDL-C control in individuals at high and very high risk for CVD, a new injectable innovative family of lipid-lowering (LL) monoclonal antibodies against the protein convertase subtilisin/kexin type 9 (PCSK9) has been approved. However, the effect of these drugs on vascular function, such as ROS generation and arterial stiffness, has not already been extensively described. In this report, we present data from 18 males with high to very high CV risk undergoing LL treatment (LLT) with either statin and ezetimibe or ezetimibe monotherapy, who experienced, after a 2-month treatment with Evolocumab, a significant improvement in blood pressure (BP)-adjusted carotid-femoral pulse wave velocity (cfPWV) (p-value = 0.0005 in the whole cohort, p-value = 0.0046 in the sub-cohort undergoing background LLT with statin and ezetimibe, p-value = 0.015 in the sub-cohort undergoing background LLT with ezetimibe monotherapy), which was significantly associated with a decrease in freshly isolated leukocytes (PBMCS)-derived H2O2 production (p-value = 0.004, p-value = 0.02 and p-value = 0.05, respectively, in the whole cohort, in the statin + ezetimibe sub-cohort, and the ezetimibe sub-cohort). Our observations support the role of systemic oxidative stress in atherosclerosis and give a further rationale for using Evolocumab also for its effect in vascular disorders linked to oxidative processes