Bioethical Issues in Frankenstein and Mutation

In this research paper we focus on bioethical issues in Mary Shelley’s Frankenstein and Robin Cook’s Mutation. Mary Shelley wrote her famous novel against technology and medical treatments that harm more than good. Mary Shelley’s work is an eye opener to our society. The issue she raises that how scientific progress harm our society. The main theme of his work is how technology turns into distraction which now-a-days is related to fear of terrorism and bioterrorism and so other disastrous things. Robin Cook who is the master of medical thriller has written Mutation on the same theme. His strategies are similar with Mary Shelley’s Frankenstein

Designing and Simulation of Various Class-F Radio-Frequency Power Amplifier

In this thesis, the various kinds of Class-F radio frequency power amplifiers are discussed. The Class-F3 RFPA is the one which has been designed and analyzed. It consists of an RF choke, blocking capacitor and a loading network. The loading network consists of a tank circuit resonating at fundamental operating frequency and also a parallel resonator circuit tuned to third harmonic. For a better understanding of the operation of Class-F3 amplifier, we go back to Class-C amplifier and discuss it briefly. Here the design remains same, operating at conduction angles less than 180 degree. The design equations were used to derive required circuit parameters on MATLAB. The designed circuit is implemented on SABER circuit simulator and resulting waveforms and frequency spectrums are also presented. The dependence of Class-F3 operation on gate-to-source voltage of a MOSFET is presented by varying it and showing the changes in the drain-to-source voltage and drain current. The frequency spectrum helps understand the harmonics in both signals. A design of the Class-F3 RFPA is presented with drain-source capacitance. A design for Class-F3 amplifier was produced where the MOSFET is forced to work in linear operating region and it is simulated in SABER. The plotted SABER simulation results are in agreement with the theoretically derived results. The simulated circuit efficiencies are a little less than what was calculated theoretically. The spectrums help clarify the results obtained

Differential and coherent processing patterns from small RNAs

Post-transcriptional processing events related to short RNAs are often reflected in their read profile patterns emerging from high-throughput sequencing data. MicroRNA arm switching across different tissues is a well-known example of what we define as differential processing. Here, short RNAs from the nine cell lines of the ENCODE project, irrespective of their annotation status, were analyzed for genomic loci representing differential or coherent processing. We observed differential processing predominantly in RNAs annotated as miRNA, snoRNA or tRNA. Four out of five known cases of differentially processed miRNAs that were in the input dataset were recovered and several novel cases were discovered. In contrast to differential processing, coherent processing is observed widespread in both annotated and unannotated regions. While the annotated loci predominantly consist of ~24nt short RNAs, the unannotated loci comparatively consist of ~17nt short RNAs. Furthermore, these ~17nt short RNAs are significantly enriched for overlap to transcription start sites and DNase I hypersensitive sites (p-value < 0.01) that are characteristic features of transcription initiation RNAs. We discuss how the computational pipeline developed in this study has the potential to be applied to other forms of RNA-seq data for further transcriptome-wide studies of differential and coherent processing

A Study of Aerodynamic Performance of a Contra Rotating Axial Compressor Stage

This article presents an experimental investigation into the effect of speed ratio and axial spacing between contra-rotors on the aerodynamic performance of a contra-stage. The traverses of flow structure and pressure variation are examined at upstream of the first and the second rotor to illustrate the effect of speed ratio and axial spacing on the aerodynamic performances. The traverse results are analysed to obtain relative total head loss and blade element efficiency of the contra-rotors. The reveals that the aerodynamics of a contra-stage is significantly affected by the speed ratio as well as the axial spacing between contra-rotors

Emerging applications of read profiles towards the functional annotation of the genome

Functional annotation of the genome in various species is important to understand their phenotypic complexity. The road towards functional annotation involves several challenges ranging from experiments on individual molecules to large-scale analysis of high-throughput sequencing (HTS) data. HTS data is typically a result of the protocol designed to address specific research questions. The sequencing results in reads, which when mapped to a reference genome often leads to the formation of distinct patterns (read profiles). Interpretation of these read profiles are essential for the analysis in relation to the research question addressed. Several strategies have been employed at varying levels of abstraction ranging from a somewhat ad hoc to a more systematic analysis of read profiles. These include methods which can compare read profiles, e.g. from direct (non-sequence based) alignments to classification of patterns into functional groups. In this review, we highlight the emerging applications of read profiles for the annotation of non-coding RNA and cis-regulatory regions such as enhancers and promoters. We also discuss the biological rationale behind their formation

A Study of Aeroacoustic Performance of a Contra-Rotating Axial Flow Compressor Stage

The paper reports of an experimental investigation into the aeroacoustic performance of a contra-rotating axial flow compressor stage having a hub-tip ratio of 0.66. Aerodynamic superiority of a contra-stage is examined from the point of view of higher pressure rise, increased through flow and rotating stall suppression. Measurements of sound pressure level and real-time analysis of the noise signals is reported for two axial gap between the rotors on the aeroacoustic performance is discussed. The study reveals that the axial gap between the rotors significantly affects the aeroacoustic performance of a contra-stage

FOOD FORTIFICATION: A NUTRITIONAL MANAGEMENT STRATEGY IN INDIA

Although the concept and implementation of food fortification are not novel in India, still since Food Safety and Standards Authority of India (FSSAI) introduced it mandatory, the paradigm of food fortification has been broadened. In the current regulation, common staple foods such as wheat flour, rice, edible oil, milk in addition to salt, and Vanaspati have been selected as food vehicle for different micronutrient fortifications. In the present review, we discussed different policies and strategies to address the public health problem associated with nutritional deficiencies with a special emphasis on food fortification. We used data and information in regard to different policies and food fortification published on governmental websites and several published scientific reports and papers were used to understand and discuss the topic. Although there are continuous efforts to mitigate nutritional deficiencies in the country, the optimum results are yet to receive. Food fortification mandate can be expected a potential tool in this context. So far, the trials conducted with fortified foods in India mostly were found having positive results to improve the nutritional status of the subjects included in the study. However, there is sufficient scope and necessity to broaden the trial design including the population of different age groups and socioeconomic status with special emphasis on female of childbearing age and geriatric population. Awareness of nutrition through continuous monitoring of the nutritional profiling of population and timely implement and revision of policies are utmost important to achieve the goal of nutritional security of the country

Cervical ectopic pregnancy: a rare case report

Cervical ectopic pregnancy is rare condition which occurs in less than 1% of all ectopic pregnancies. Early diagnosis is a key to successful management; delayed diagnosis can lead to significant morbidity and fertility loss of the mother. We present a case of woman who presented with vaginal bleeding and lower abdominal pain for 3 days following amenorrhea of 3 ½ months. Ultrasound examination done outside was suggestive of left tubal ectopic pregnancy whereas scan done at our hospital indicated either uterine rupture within intraperitoneal sac or a cervical ectopic pregnancy. She was taken up for laparotomy and hysterectomy since she was bleeding profusely, and it was lifesaving

Evaluation of Reid’s Combined Colposcopic Index as a predictor of cervical intraepithelial lesion

Background: Carcinoma cervix is the commonest cancer among women worldwide and in India it accounts for 80% of all genital cancers. Screening methods include cervical cytology, human papilloma virus testing and colposcopy. Objective of present study was to evaluate suspicious cervix colposcopically using Reids Colposcopic Index (RCI) and to correlate RCI with histopathological findings.Methods: This was a prospective cross sectional study done on 125 women with clinical diagnosis of suspicious cervix. Colposcopy was performed and grading of the disease was done according to RCI. Positive cases were subjected to cervical biopsy and endocervical curettage was performed in unsatisfactory colposcopy.Results: Colposcopy was done on 125 women with suspicious cervix. Out of 125, sixty two showed abnormal colposcopic findings which were graded according to RCI into Low grade disease predicting histological diagnosis of CIN1 in 47, Intermediate grade disease predicting histological diagnosis of CIN1/2 in 11 and High grade disease predicting histological diagnosis of CIN2/3 in 4 women. Colposcopy of one women suggested invasive carcinoma and was confirmed on histopathology to be microinvasive squamous cell carcinoma. Six women with unsatisfactory colposcopy showed benign histopathology. Sensitivity, specificity, predictive value and false negative rate of colposcopy for invasive disease was 50%, 100%, 100% and 1.60% respectively with 98.40% diagnostic accuracy. Colposcopic diagnosis of invasive disease and histopathology report showed 100% correlation.Conclusions: Correlation between RCI and histopathology was good. Predictive accuracy of colposcopy increased with increasing severity of disease

Effect of long term application of organic and inorganic fertilizer on productivity and water use efficiency of pearl millet under rainfed condition

Not AvailableEffect of long term application of organic and inorganic fertilizer on productivity and water use efficiency of pearl millet under rainfed conditionNot Availabl