Modelling detailed information flows in building design with the parameter-based design structure matrix

The Architecture/Engineering/Construction (AEC) industry is one of the multidisciplinary domains in which collaboration among related parties is of utmost importance. Despite the intense flow of information between design professionals, there is a lack of research to better understand and manipulate these flows. Most of the current process modelling tools in the AEC industry do not enable analyses of iterative information cycles. Moreover, these tools represent the process at high levels, thus, they are inadequate for multi-parameter problems like building design. With a view to alleviate these problems, this paper introduces the use of parameter-based design structure matrix as a process modelling and system analysis tool for building design. The method reveals insights into the process structure, optimum sequence of parameter decisions, iterative cycles and concurrency in the process. The application of the method is demonstrated through a case study on suspended ceiling design in a real-life project. © 2005 Elsevier Ltd. All rights reserved

A knowledge-based space planning system

Knowledge-based systems are potentially powerful tools for improving the results of automated or interactive design procedures. Expert Space Planner is a prototype of such a system that uses production rules in the spatial planning of panel houses. © 1992 Taylor and Francis Group, LLC

Modelling detailed information flows in building design with the parameter-based design structure matrix

The Architecture/Engineering/Construction (AEC) industry is one of the multidisciplinary domains in which collaboration among related parties is of utmost importance. Despite the intense flow of information between design professionals, there is a lack of research to better understand and manipulate these flows. Most of the current process modelling tools in the AEC industry do not enable analyses of iterative information cycles. Moreover, these tools represent the process at high levels, thus, they are inadequate for multi-parameter problems like building design. With a view to alleviate these problems, this paper introduces the use of parameter-based design structure matrix as a process modelling and system analysis tool for building design. The method reveals insights into the process structure, optimum sequence of parameter decisions, iterative cycles and concurrency in the process. The application of the method is demonstrated through a case study on suspended ceiling design in a real-life project

Raw data - Digital scans - Sepsis Induces Heterogeneous Transcription of Coagulation- and Inflammation-Associated Genes in Renal Microvasculature

Raw data of the manuscript "Sepsis Induces Heterogeneous Transcription of Coagulation- and Inflammation-Associated Genes in Renal Microvasculature" is included. Types of included data are: - NDPI files of digital scans showing immunohistochemical (IHC) protein staining in mouse kidney - NDPI files of digital scans showing Martius Scarlet Blue staining (MSB) in mouse kidne

Mutanobactin D from the human microbiome: total synthesis, configurational assignment, and biological evaluation

Mutanobactin D is a non-ribosomal, cyclic peptide isolated from Streptococcus mutans and shows activity reducing yeast-to-hyphae transition as well as biofilm formation of the pathogenic yeast Candida albicans. We report the first total synthesis of this natural product, which relies on enantioselective, zinc-mediated 1,3-dipolar cycloaddition and a sequence of cascading reactions, providing the key lipidated γ-amino acid found in mutanobactin D. The synthesis enables configurational assignment, determination of the dominant solution-state structure, and studies to assess the stability of the lipopeptide substructure found in the natural product. The information stored in the fingerprint region of the IR spectra in combination with quantum chemical calculations proved key to distinguishing between epimers of the α-substituted β-keto amide. Synthetic mutanobactin D drives discovery and analysis of its effect on growth of other members of the human oral consortium. Our results showcase how total synthesis is central for elucidating the complex network of interspecies communications of human colonizers

Raw data - Unique miRNome and Transcriptome Profiles Underlie Microvascular Heterogeneity in Mouse Kidney

Raw data of the manuscript "Unique miRNome and Transcriptome Profiles Underlie Microvascular Heterogeneity in Mouse Kidney" is included. Types of included data are - NDPI files showing immunohistochemistry or in situ hybridisation in mouse kidney - Differential expression analysis data from both small RNA sequencing and RNA sequencing - Raw CT values of all included RT-qPCRs</p

Can Volunteered Geographic Information be a participant in eEnvironment and SDI?

We investigate the potential role Volunteered Geographic Information (VGI) can play in eEvironment and various Spatial Data Infrastructures (SDI) on a local, regional, and national level. eEnvironment is the use and promotion of ICT for the purposes of environmental assessment and protection, spatial planning, and the sustainable use of natural resources. An SDI provides an institutionally sanctioned, automated means for posting, discovering, evaluating, and exchanging geospatial information by participating information producers and users. A key common theme shared by both definitions is public participation and user-centric services. We pose the research question: is VGI (an example of public participation and collaboration) is ready to participate in eEnvironment and SDI