Dennis Levine, an exception or the Norm: Inside Trading and Foreign Bank Secrecy

As national securities markets rapidly become international markets, the idealized precept that federal securities laws are to create a system providing equal access to information for all investors, appears to falter. One cause of this breakdown is insider trading. Traditionally prosecuted under the Securities Exchange Act of 1934,• illegal activities conducted through secret bank accounts outside U.S. borders and jurisdiction have posed a sobering challenge to prosecution of the inside trader

Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry

This document is the Accepted Manuscript version of a Published Work that appeared in final form in, copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.analchem.8b00484.A transformation product of trimethoprim, a contaminant of emerging concern in the environment, is generated using an electro-assisted Fenton reaction and analyzed using differential mobility spectrometry (DMS) in combination with MS/MS techniques and computational calculations to develop a rapid method for identification. DMS is used as a pre-filter to separate positional isomers prior to subsequent identification by mass spectrometric analyses. Collision induced dissociation of each DMS separated species is used to reveal fragmentation patterns that can be correlated to specific isomer structures. Analysis of the experimental data and supporting quantum chemical calculations show that methylene-hydroxylated and methoxy-containing phenyl ring hydroxylated transformation products are observed. The proposed methodology outlines a high-throughput technique to determine transformation products of small molecules accurately, in a short time and requiring minimal sample concentrations (<100 ng/mL).NSERC Discovery Grant 30345

Separating and probing tautomers of protonated nucleobases using differential mobility spectrometry

The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.ijms.2017.08.008 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/The protonated nucleobases (C+H)+, (T+H)+, (U+H)+, (A+H)+, and (G+H)+ are investigated in a combined experimental and computational study using differential mobility spectrometry (DMS), mass spectrometry, and electronic structure calculations. DMS is used to isolate individual tautomeric forms for each protonated nucleobase prior to characterization with HDX or CID. The population distributions of each protonated nucleobase formed by electrospray ionization (ESI) are dominated by a single tautomeric form, as is predicted by our calculations. However, all nucleobases present additional tautomers upon ESI, with these minor contributions to the ensemble populations attributed to additional higher energy metastable species. In addition to the tautomer-derived species, additional ion signals in the DMS data are attributed to larger nucleobase-containing clusters, which fragment post-DMS to yield bare ion and fragment ion signals that are consistent with those expected for the bare protonated nucleobases. Contributions from larger clustered species are instead distinguished by monitoring DMS ion signal as declustering potential voltages are ramped.Natural Sciences and Engineering Research Council (NSERC) of CanadaDiscovery Grant, Collaborative Research and Development Grant programsOntario Centres of ExcellenceVIP-II gran