Thermal effects of carbonated hydroxyapatite modified by glycine and albumin

In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydration, decarboxylation and thermal degradation of amino acid and protein connected to the surface of solid phase occur. The tendency of temperature lowering of the decomposition of powders synthesized from a medium containing organic substances was determined. Results demonstrate a direct dependence between the concentration of the amino acid in a model solution and its content in the solid phase

The potential of bacteriophages in the treatment of ENT infections in children

Less than a century of use of antimicrobial drugs in the treatment of infectious and inflammatory diseases has demonstrated the ample potential of strains of various microorganismsto to adapt to the toxic effects of these drugs. Over the past decade, the resistance of infectious agents to antimicrobial drugs widely used in otorhinolaryngology has greatly increased. The incidence of ENT diseases is higher in children than in adults, while viral diseases in children are often complicated by bacterial inflammations, resulting in the search for new methods of causal treatment. A review of the literature demonstrated the validity of phage therapy in the treatment of ENT diseases in children both locally and systemically, as well as in combination with the conventional antibiotic therapy. The benefits of bacteriophages include high specificity for certain microorganisms, good compatibility with other medications, minimal risk of adverse events and absence of allergic reactions

POSSIBILITIES OF USE OF THE MODERN ANTIHISTAMINE MEDICINES IN THERAPY OF PATIENTS WITH ALLERGIC RHINITIS

Allergic rhinitis as one of the most common non-infectious respiratory inflammatory diseases is a global public health problem. The course of allergic rhinitis, its effect on the pathology of other organs and systems, the likelihood of complications and many other aspects of this pathology are largely determined by timely diagnosis and adequate treatment. At the heart of the pathogenesis of allergic rhinitis is the immediate allergic reaction. Histamine is the most important biogenic amine, the physiological regulator of the activity of various cells and systems and one of the main mediators of allergic reactions of immediate type. In the treatment of allergic rhinitis, one of the key places is occupied by antihistamines. One of such highly effective modern antihistamines is levocetirizine – a blocker of H1 histamine receptors of the second generation. Leveltzetirizine affects the histamine-dependent stage of allergic reactions, reduces vascular permeability and eosinophil migration, limits the release of inflammatory mediators, significantly influences the formation of edema of the tissues and the production of mucus, prevents development and greatly facilitates the course of the allergic reaction, has antiexudative, antipruritic and anti-inflammatory effects, and a pronounced ability to eliminate nasal obstruction in patients with seasonal allergic rhinitis. The drug levocetirizine Allerway®, bioequivalent to the original drug, is of definite interest to physicians of various specialties

Benefits of using ecoantibiotics in the treatment of inflammatory diseases of ENT organs

Different types of microorganisms can be the causative agents of inflammatory diseases of the respiratory tract and ear of a man. In most patients inflammatory changes in the airways begin with the invasion of respiratory viruses [1–3]. In adverse course of the viral disease activation of endogenous bacterial agents colonizing the mucosa of the respiratory tract or superinfection of pathogenic flora occurs [1, 4]. The inclusion of antimicrobial agents in the scheme of complex therapy of bacterial infections of the respiratory tract and the ear is justified in most clinical cases [4, 7]. An important problem of system etiotropic therapy are adverse drug effects and adverse effects, in particular excess growth of pathogenic bacteria as a result of suppression of obligate microbiota [6, 8]

Periostin as a promising biological marker of early recurrence of polyposis rhinosinusitis after surgical treatment

Introduction. In spite of the numerous studies devoted to the issues of chronic rhinosinusitis with nasal polyps, the urgency of this problem remains due to the high incidence of the disease. The relapsing course of chronic rhinosinusitis with nasal polyps determines the uncontrolled course of bronchial asthma by patients with combined pathology. The main goal of case management of patients with chronic rhinosinusitis with nasal polyps is to achieve control over the polyposis process. It has been shown, that a promising direction is the study of biological markers. Goal. Study of the concentration of serum periostin in combination with serum eosinophilia and the number of eosinophils of the nasal secretion to predict early recurrence of chronic rhinosinusitis with nasal polyps after surgical treatment.Materials and methods. The study included 47 patients with a diagnosis of chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis with nasal polyps in combination with bronchial asthma. All patients underwent bilateral endoscopic polysinusotomy followed by case follow-up for a year. The diagnosis of bronchial asthma was made based on the diagnostic criteria defined in the Global Strategy for the Treatment and Prevention of Bronchial Asthma and in the Federal Clinical Guidelines for the Diagnosis and Treatment of Bronchial Asthma. All patients were consulted by a pulmonologist. Control examinations of patients were carried out every 3 months. All patients underwent a study of the concentration of periostin in the blood serum. Blood probe samples were taken before the start of treatment and after 12 months.Results and discussion. In the course of the study, was proved the relationship between a high concentration of serum periostin in combination with increased eosinophils of blood and nasal secretion with an early relapse of polyposis rhinosinusitis.Conclusions. An increased concentration of serum periostin before surgical treatment is a prognostically unfavorable factor for early recurrence of chronic rhinosinusitis with nasal polyps

CEFDITOREN IN THE TREATMENT OF PURULENT RINOSINUSITIS

Rhinosinusitis is one of the most common human nosologies. Treatment of acute forms of rhinosinusitis should be comprehensive and directed, first of all, to the eradication of the infectious agent, as well as to restore aeration of the sinuses and drainage function of the anastomosis. With the development of bacterial inflammation, it is necessary to decide the feasibility of systemic antimicrobial therapy. With starting empirical therapy, the drug of choice is amoxicillin, but at the risk of antibiotic resistance, as well as the ineffectiveness of starting therapy, it is recommended to use protected aminopenicillins or cephditoren. Spectraceph (cephditoren) is effective in the therapy of patients acute purulent rhinosinusitis, including with prolonged, recurrent course

The relevance of the application mukoactive preparations in patients with inflammatory pathology of ent organs

The mucous membrane of the respiratory tract is the first line of protection of the human body from various damaging agents. This function is provided by mucociliary clearance and its component by mucociliary transport. Optimum work of ciliated epithelium is possible only with normal rheology of mucous secretion - viscosity, elasticity, adhesiveness. The development of mucociliary dysfunction is the main pathogenetic mechanism of almost all inflammatory diseases of the respiratory tract and middle ear. The main areas of treatment for patients with infectious and inflammatory diseases of the respiratory tract and ear are evacuation of the pathological secretion, restoration of the synthesis of physiological mucus and a positive effect on the restructuring of the respiratory epithelium. The effectiveness of a mucoactive drug is determined by its ability to directly affect several components of mucociliary clearance - regulation of viscosity and secretion composition, its formation processes and evacuation rate. These characteristics correspond to carbocysteine