Stellar Activity in Coeval Open Clusters: Praesepe and The Hyades

Randich and Schmitt [1995, A&A 298, 115] found that the coronal activity of solar-type and low mass stars in Praesepe is significantly lower than that of stars in the Hyades cluster. We have carried out several tests in order to find a possible explanation for this result. We have measured radial velocities of two groups of Praesepe stars (a dF-dK sample and a dM sample) and have measured H$\alpha$ as a chromospheric activity index for the dM sample. We conclude that the Praesepe catalog used in the X-ray analysis does not contain a significant number of non-members. The comparison of the H$\alpha$ equivalent widths for the M dwarfs in Praesepe with those in the Hyades indicates that, at least for stars in this mass range, the Praesepe stars are as active or more active than their Hyades counterparts. We have also analyzed a few ROSAT PSPC pointings of Praesepe in order to obtain a new and independent estimate of the X-ray luminosities and upper limits for a small sample of Praesepe members concluding that the small differences between the old and new upper limits are not large enough to explain the dichotomy in the X-ray properties of Praesepe and the Hyades. Therefore, our examination of the available data does not provide a clear reason to explain why the X-ray luminosity functions of the two clusters are different. Part of the explanation could be found in the binaries. Speculatively, these clusters could have different orbital period distributions, with more short period binaries among the Hyades, which would show larger coronal activity.Comment: Accepted for publiction in Ap

The Standard Model from a New Phase Transition on the Lattice

Several years ago it was conjectured in the so-called Roma Approach, that gauge fixing is an essential ingredient in the lattice formulation of chiral gauge theories. In this paper we discuss in detail how the gauge-fixing approach may be realized. As in the usual (gauge invariant) lattice formulation, the continuum limit corresponds to a gaussian fixed point, that now controls both the transversal and the longitudinal modes of the gauge field. A key role is played by a new phase transition separating a conventional Higgs or Higgs-confinement phase, from a phase with broken rotational invariance. In the continuum limit we expect to find a scaling region, where the lattice correlators reproduce the euclidean correlation functions of the target (chiral) gauge theory, in the corresponding continuum gauge.Comment: 16 pages, revtex, one figure. Clarifications made, mainly in sections 3 and 6 that deal with the fermion action, to appear in Phys Rev

The ACS Survey of Galactic Globular Clusters XI: The Three-Dimensional Orientation of the Sagittarius Dwarf Spheroidal Galaxy and its Globular Clusters

We use observations from the ACS study of Galactic globular clusters to investigate the spatial distribution of the inner regions of the disrupting Sagittarius dwarf spheroidal galaxy (Sgr). We combine previously published analyses of four Sgr member clusters located near or in the Sgr core (M54, Arp 2, Terzan 7 and Terzan 8) with a new analysis of diffuse Sgr material identified in the background of five low-latitude Galactic bulge clusters (NGC 6624, 6637, 6652, 6681 and 6809) observed as part of the ACS survey. By comparing the bulge cluster CMDs to our previous analysis of the M54/Sgr core, we estimate distances to these background features. The combined data from four Sgr member clusters and five Sgr background features provides nine independent measures of the Sgr distance and, as a group, provide uniformly measured and calibrated probes of different parts of the inner regions of Sgr spanning twenty degrees over the face of the disrupting dwarf. This allows us, for the first time, to constrain the three dimensional orientation of Sgr's disrupting core and globular cluster system and compare that orientation to the predictions of an N-body model of tidal disruption. The density and distance of Sgr debris is consistent with models that favor a relatively high Sgr core mass and a slightly greater distance (28-30 kpc, with a mean of 29.4 kpc). Our analysis also suggests that M54 is in the foreground of Sgr by ~2 kpc, projected on the center of the Sgr dSph. While this would imply a remarkable alignment of the cluster and the Sgr nucleus along the line of sight, we can not identify any systematic effect in our analysis that would falsely create the measured 2 kpc separation. Finally, we find that the cluster Terzan 7 has the most discrepant distance (25 kpc) among the four Sgr core clusters, which may suggest a different dynamical history than the other Sgr core clusters.Comment: 41 pages, 16 figures, accepted to Ap

Leptin mediates the increase in blood pressure associated with obesity.

Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species

Benefits and harms of perioperative high fraction inspired oxygen for surgical site infection prevention: a protocol for a systematic review and meta-analysis of individual patient data of randomised controlled trials.

INTRODUCTION The use of high fraction of inspired oxygen (FiO2) intraoperatively for the prevention of surgical site infection (SSI) remains controversial. Promising results of early randomised controlled trials (RCT) have been replicated with varying success and subsequent meta-analysis are equivocal. Recent advancements in perioperative care, including the increased use of laparoscopic surgery and pneumoperitoneum and shifts in fluid and temperature management, can affect peripheral oxygen delivery and may explain the inconsistency in reproducibility. However, the published data provides insufficient detail on the participant level to test these hypotheses. The purpose of this individual participant data meta-analysis is to assess the described benefits and harms of intraoperative high FiO2compared with regular (0.21-0.40) FiO2 and its potential effect modifiers. METHODS AND ANALYSIS Two reviewers will search medical databases and online trial registries, including MEDLINE, Embase, CENTRAL, CINAHL, ClinicalTrials.gov and WHO regional databases, for randomised and quasi-RCT comparing the effect of intraoperative high FiO2 (0.60-1.00) to regular FiO2 (0.21-0.40) on SSI within 90 days after surgery in adult patients. Secondary outcome will be all-cause mortality within the longest available follow-up. Investigators of the identified trials will be invited to collaborate. Data will be analysed with the one-step approach using the generalised linear mixed model framework and the statistical model appropriate for the type of outcome being analysed (logistic and cox regression, respectively), with a random treatment effect term to account for the clustering of patients within studies. The bias will be assessed using the Cochrane risk-of-bias tool for randomised trials V.2 and the certainty of evidence using Grading of Recommendations, Assessment, Development and Evaluation methodology. Prespecified subgroup analyses include use of mechanical ventilation, nitrous oxide, preoperative antibiotic prophylaxis, temperature (2.5 hour). ETHICS AND DISSEMINATION Ethics approval is not required. Investigators will deidentify individual participant data before it is shared. The results will be submitted to a peer-review journal. PROSPERO REGISTRATION NUMBER CRD42018090261

Skeletal muscle properties and fatigue resistance in relation to smoking history

Although smoking-related diseases, such as chronic obstructive pulmonary disease (COPD), are often accompanied by increased peripheral muscle fatigability, the extent to which this is a feature of the disease or a direct effect of smoking per se is not known. Skeletal muscle function was investigated in terms of maximal voluntary isometric torque, activation, contractile properties and fatigability, using electrically evoked contractions of the quadriceps muscle of 40 smokers [19 men and 21 women; mean (SD) cigarette pack years: 9.9 (10.7)] and age- and physical activity level matched non-smokers (22 men and 23 women). Maximal strength and isometric contractile speed did not differ significantly between smokers and non-smokers. Muscle fatigue (measured as torque decline during a series of repetitive contractions) was greater in smokers (P = 0.014), but did not correlate with cigarette pack years (r = 0.094, P = 0.615), cigarettes smoked per day (r = 10.092, P = 0.628), respiratory function (%FEV1pred) (r = −0.187, P = 0.416), or physical activity level (r = −0.029, P = 0.877). While muscle mass and contractile properties are similar in smokers and non-smokers, smokers do suffer from greater peripheral muscle fatigue. The observation that the cigarette smoking history did not correlate with fatigability suggests that the effect is either acute and/or reaches a ceiling, rather than being cumulative. An acute and reversible effect of smoking could be caused by carbon monoxide and/or other substances in smoke hampering oxygen delivery and mitochondrial function

Kinematics and Chemistry of Stars Along the Sagittarius Trailing Tidal Tail and Constraints on the Milky Way Mass Distribution

We present three-dimensional kinematics of Sagittarius (Sgr) trailing tidal debris in six fields located 70-130 degrees along the stream from the Sgr dwarf galaxy core. The data are from our proper-motion (PM) survey of Kapteyn's Selected Areas, in which we have measured accurate PMs to faint magnitudes in 40x40 arcmin fields evenly spaced across the sky. The radial velocity (RV) signature of Sgr has been identified among our follow-up spectroscopic data in four of the six fields and combined with mean PMs of spectroscopically-confirmed members to derive space motions of Sgr debris based on 15-64 confirmed stream members per field. These kinematics are compared to predictions of the Law & Majewski (2010) model of Sgr disruption; we find reasonable agreement with model predictions in RVs and PMs along Galactic latitude. However, an upward adjustment of the Local Standard of Rest velocity Theta_LSR from its standard 220 km/s to at least $232\pm14$ km/s (and possibly as high as $264\pm23$ km/s) is necessary to bring 3-D model debris kinematics and our measurements into agreement. Satisfactory model fits that simultaneously reproduce known position, distance, and radial velocity trends of the Sgr tidal streams, while significantly increasing Theta_LSR}, could only be achieved by increasing the Galactic bulge and disk mass while leaving the dark matter halo fixed to the best-fit values from Law & Majewski (2010). We derive low-resolution spectroscopic abundances along this stretch of the Sgr stream and find a constant [Fe/H] = -1.15 (with ~0.5 dex scatter in each field -- typical for dwarf galaxy populations) among the four fields with reliable measurements. A constant metallicity suggests that debris along the ~60-degree span of this study was all stripped from Sgr on the same orbital passage.Comment: 26 pages, 24 figures (some with degraded resolution), accepted to ApJ; full-resolution version available at http://www.rpi.edu/~carlij/sgr_paper/ms.apjformat.ps.g

Monitoring quality of care in hepatocellular carcinoma: A modified delphi consensus

Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of quality indicators (QIs) to underpin the management of HCC. We undertook a modified, two-round, Delphi consensus study comprising a working group and experts involved in the management of HCC as well as consumer representatives. QIs were derived from an extensive review of the literature. The role of the participants was to identify the most important and measurable QIs for inclusion in an HCC clinical quality registry. From an initial 94 QIs, 40 were proposed to the participants. Of these, 23 QIs ultimately met the inclusion criteria and were included in the final set. This included (a) nine related to the initial diagnosis and staging, including timing to diagnosis, required baseline clinical and laboratory assessments, prior surveillance for HCC, diagnostic imaging and pathology, tumor staging, and multidisciplinary care; (b) thirteen related to treatment and management, including role of antiviral therapy, timing to treatment, localized ablation and locoregional therapy, surgery, transplantation, systemic therapy, method of response assessment, and supportive care; and (c) one outcome assessment related to surgical mortality. Conclusion: We identified a core set of nationally agreed measurable QIs for the diagnosis, staging, and management of HCC. The adherence to these best practice QIs may lead to system-level improvement in quality of care and, ultimately, improvement in patient outcomes, including survival