Interceptor effect of C₆₀ fullerene on the in vitro action of aromatic drug molecules

In this work we are focusing on studying the influence of the pristine C₆₀ fullerene on biological activity of some aromatic drug molecules in human buccal epithelial cells. Assessment of the heterochromatin structure in the cell nucleus as well as the barrier function of the cell membrane was performed. The methods of cell microelectrophoresis and atomic force microscopy were also applied. A concentration-dependent restoration of the functional activity of the cellular nucleus after exposure to DNA -binding drugs (doxorubicin, proflavine and ethidium bromide) has been observed in human buccal epithelial cells upon addition of C₆₀ fullerene at a concentration of ~10−5

Hyperthermic effect of multi-walled carbon nanotubes stimulated with near infrared irradiation for anticancer therapy: in vitro studies

It is proposed to use the novel paradigm of treating cancer with hyperthermic therapy using multi-walled carbon nanotubes (MWCNT) stimulated with near infrared (NIR) irradiation. Aim: To establish the capacity of MWCNT stimulated with NIR irradiation to destroy Erlich ascitic carcinoma (EAC) cells. Materials and Methods: EAC cells suspension was irradiated with NIR heating lamp with a wavelength of 0.78–1.40 mm and power density of 3.5 W/cm2 over 1.5 min in the presence of MWCNT (0.1 mg/ml). The changes in the temperature of suspension with the NIR exposure time was measured using the differential cooper-constantan thermocouple. The viability of EAC cells was evaluated by trypan blue staining. Results: The death of 95.2% of EAC cells in the presence of MWCNT was observed after 1.5 min of NIR light irradiation: thermal ablation temperature was ~50 °C. Conclusions: It was demonstrated that addition of MWCNT to EAC cell suspension results in the photo-ablative destruction of cells exposed to short time NIR irradiation

Antitumor efficiency of the natural alkaloid berberine complexed with C₆₀ fullerene in Lewis lung carcinoma in vitro and in vivo

Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choosing the right dose, there is a need to improve approaches of Ber use in anticancer therapy. In this study, Ber, noncovalently bound to a carbon nanostructure C₆₀ fullerene at various molar ratios of the components, was explored against Lewis lung carcinom

Antitumor effects and hematotoxicity of С60-Cis-Pt nanocomplex in mice with lewis lung carcinoma

To estimate the antitumor effects of С60-Cis-Pt nanocomplex in Lewis lung carcinoma (LLC) and analyze hematological toxicity in tumor-bearing mic

A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicity

The self-organization of C60 fullerene and cisplatin in aqueous solution was investigated using the computer simulation, dynamic light scattering and atomic force microscopy techniques. The results evidence the complexation between the two compound

Complex of C₆₀ fullerene with doxorubicin as a promising agent in antitumor therapy

The main aim of this work was to evaluate the effect of doxorubicin in complex with C₆₀ fullerene (C₆₀ + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C₆₀ + Dox complex actio

Complex of C₆₀ fullerene with doxorubicin as a promising agent in antitumor therapy

The main aim of this work was to evaluate the effect of doxorubicin in complex with C₆₀ fullerene (C₆₀ + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C₆₀ + Dox complex actio

Effect of fullerene C60 on ATPase activity and superprecipitation of skeletal muscle actomyosin: Vplyv fulerenu C60 na ATPaznu aktyvnistʹ ta superprecypitaciju aktomiozynu skeletnych mʹjaziv

Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit skeletal muscle natural actomyosin has been revealed, namely an increase of actomyosin superprecipitation and Мg2+, Са2+– and K+-ATPase activity by fullerene was investigated. We conclude that this finding offers a real possibility for the regulation of contraction-relaxation of skeletal muscle with fullerene C60