62 research outputs found
Multimode quantum interference of photons in multiport integrated devices
We report the first demonstration of quantum interference in multimode
interference (MMI) devices and a new complete characterization technique that
can be applied to any photonic device that removes the need for phase stable
measurements. MMI devices provide a compact and robust realization of NxM
optical circuits, which will dramatically reduce the complexity and increase
the functionality of future generations of quantum photonic circuits
Heralded Noiseless Amplification of a Photon Polarization Qubit
Non-deterministic noiseless amplification of a single mode can circumvent the
unique challenges to amplifying a quantum signal, such as the no-cloning
theorem, and the minimum noise cost for deterministic quantum state
amplification. However, existing devices are not suitable for amplifying the
fundamental optical quantum information carrier, a qubit coherently encoded
across two optical modes. Here, we construct a coherent two-mode amplifier, to
demonstrate the first heralded noiseless linear amplification of a qubit
encoded in the polarization state of a single photon. In doing so, we increase
the transmission fidelity of a realistic qubit channel by up to a factor of
five. Qubit amplifiers promise to extend the range of secure quantum
communication and other quantum information science and technology protocols.Comment: 6 pages, 3 figure
Magnesium induces neuronal apoptosis by suppressing excitability
In clinical obstetrics, magnesium sulfate (MgSO4) use is widespread, but effects on brain development are unknown. Many agents that depress neuronal excitability increase developmental neuroapoptosis. In this study, we used dissociated cultures of rodent hippocampus to examine the effects of Mg++ on excitability and survival. Mg++-induced caspase-3-associated cell loss at clinically relevant concentrations. Whole-cell patch-clamp techniques measured Mg++ effects on action potential threshold, action potential peak amplitude, spike number and changes in resting membrane potential. Mg++ depolarized action potential threshold, presumably from surface charge screening effects on voltage-gated sodium channels. Mg++ also decreased the number of action potentials in response to fixed current injection without affecting action potential peak amplitude. Surprisingly, Mg++ also depolarized neuronal resting potential in a concentration-dependent manner with a +5.2 mV shift at 10 mM. Voltage ramps suggested that Mg++ blocked a potassium conductance contributing to the resting potential. In spite of this depolarizing effect of Mg++, the net inhibitory effect of Mg++ nearly completely silenced neuronal network activity measured with multielectrode array recordings. We conclude that although Mg++ has complex effects on cellular excitability, the overall inhibitory influence of Mg++ decreases neuronal survival. Taken together with recent in vivo evidence, our results suggest that caution may be warranted in the use of Mg++ in clinical obstetrics and neonatology
Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads
Over 60 million people in sub-Saharan Africa are at risk of infection with the parasite Trypanosoma brucei which causes Human African Trypanosomiasis (HAT), also known as sleeping sickness. The disease results in systemic and neurological disability to its victims. At present, only four drugs are available for treatment of HAT. However, these drugs are expensive, limited in efficacy and are severely toxic, hence the need to develop new therapies. Previously, the short TbruGSK-3 short has been validated as a potential target for developing new drugs against HAT. Because this enzyme has also been pursued as a drug target for other diseases, several inhibitors are available for screening against the parasite enzyme. Here we present the results of screening over 16,000 inhibitors of human GSK-3β (HsGSK-3) from the Pfizer compound collection against TbruGSK-3 short. The resulting active compounds were tested for selectivity versus HsGSK-3β and a panel of human kinases, as well as their ability to inhibit proliferation of the parasite in vitro. We have identified attractive compounds that now form potential starting points for drug discovery against HAT. This is an example of how a tripartite partnership involving pharmaceutical industries, academic institutions and non-government organisations such as WHO TDR, can stimulate research for neglected diseases
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