5 research outputs found
A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects
- Author
- Publication venue
- Elsevier Ltd
- Publication date
- 01/01/2021
- Field of study
Positive allosteric modulators (PAMs) of the μ-opioid receptor (MOR) have been proposed to exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid drugs while limiting their adverse effects or risk of overdose as a result of using lower drug doses. We herein report in vitro and in vivo characterization of two small molecules from a chemical series of MOR PAMs that exhibit: (i) MOR PAM activity and receptor subtype selectivity in vitro, (ii) a differential potentiation of the antinociceptive effect of oxycodone, morphine, and methadone in mouse models of pain that roughly correlates with in vitro activity, and (iii) a lack of potentiation of adverse effects associated with opioid administration, such as somatic withdrawal, respiratory depression, and analgesic tolerance. This series of MOR PAMs holds promise for the development of adjuncts to opioid therapy to mitigate against overdose and opioid use disorders
Magnetic resonance in Kazan and in Oxford
- Author
- A Abragam
- A. Abragam
- A. Abragam
- A. Abragam
- A. Abragam
- A. Abragam
- A.A. Antipin
- A.A. Kudryashov
- A.A. Manenkov
- A.A. Manenkov
- A.H. Cooke
- A.H. Cooke
- A.H. Cooke
- A.H. Cooke
- A.J. Freeman
- A.V. Egorov
- A.V. Egorov
- A.V. Egorov
- A.V. Egorov
- B Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B. Bleaney
- B.V. Rollin
- C.A. Hutchison
- C.A. Hutchison
- C.B.P. Finn
- C.J. Gorter
- D.M.S. Bagguley
- D.M.S. Bagguley
- D.M.S. Bagguley
- D.T. Edmonds
- E. Zavoisky
- E. Zavoisky
- E. Zavoisky
- E.M. Purcell
- F. Bloch
- F.I.B. Williams
- F.L. Aukhadeev
- G.A. Gehring
- G.K. Woodgate
- H.A. Jahn
- I. Wolf de
- I.N. Kurkin
- I.S. Konov
- I.S. Konov
- J. Frenkel
- J.A. Wyk Van
- J.A.A. Ketelaar
- J.E. Templeton
- J.F. Jacquinot
- J.H. Vleck Van
- J.H. Vleck Van
- J.H. Vleck Van
- J.H.E. Griffiths
- J.M. Baker
- J.M. Baker
- J.M. Baker
- J.M. Baker
- J.M. Baker
- J.M. Baker
- J.M. Daniels
- J.S.M. Harvey
- J.S.M. Harvey
- K.D. Bowers
- K.D. Bowers
- K.D. Bowers
- L.K. Aminov
- L.K. Aminov
- L.K. Aminov
- L.K. Aminov
- L.K. Aminov
- L.K. Aminov
- L.K. Aminov
- M.A. Teplov
- M.A. Teplov
- M.E. Newton
- M.E. Newton
- M.E. Newton
- M.H.L. Pryce
- M.J. Stevenson
- M.M. Abraham
- M.M. Abraham
- M.M. Abraham
- M.P. Vaisfel’d
- M.P. Vaisfel’d
- M.P. Vaisfel’d
- M.V. Eremin
- O.N. Bakharev
- O.N. Bakharev
- O.N. Bakharev
- O.N. Bakharev
- P.G.H. Sandars
- P.J. Brown
- R. Orbach
- R.A. Kamper
- R.E. Trees
- R.E. Walstedt
- R.P. Giffard
- R.P. Penrose
- S.A. Al’tshuler
- S.A. Al’tshuler
- S.A. Al’tshuler
- S.A. Al’tshuler
- S.A. Al’tshuler
- S.A. Al’tshuler
- V. Heine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The mapping of language in North America and the British Isles
- Author
- Aitchison J.
- Aitchison J.E.
- Alinei M.
- Allardt E.
- Allen J.P.
- Ambrose J.E.
- Ambrose J.E.
- Arbingast S.A.
- Awberry G.
- Baker A.
- Baker C.
- Ball M.J.
- Betts C.
- Bjorklund E.
- Bowen E.G.
- Bowen E.G.
- Breton R.J.
- Bright E.
- Browne D.
- Busteed M.
- Canada Ministry for Citizenship and Culture
- Carter H.
- Carter H.
- Carter H.
- Cartwright D.G.
- Cartwright D.G.
- Cassidy F.G.
- Census of Canada
- Cerny J.W.
- Chambers J.K.
- Colin H. Williams
- Conklin N.F.
- Cox K.
- Crawford T.D.
- Davies E.
- Detro R.A.
- Devine T.
- Dixon R.B.
- Donley M.W.
- Driver H.E.
- Durkacz V.E.
- Edwards V.
- Ellis A.J.
- English Place-Name Society
- Fennell D.
- Fernald E.A.
- Fitzgerald G.
- Francis W.N.
- Gannett H.
- Garrett W.E.
- Gentilcore R.L.
- Gilbert G.G.
- Giles H.
- Gunnemark E.
- Guralnik D.B.
- Hale. R.F.
- Harris R.C.
- Haugen E.
- Heizer R.F.
- Hewett E.L.
- Hofman J.E.
- Hughes A.
- Hume I.
- Hume I.
- Humphreys H.L.
- James C.
- James I.
- John B.S.
- Jones E.
- Jordan T.G.
- Kaups M.
- Keane M.J.
- Kenrick G.S.
- Kirk J.
- Kirkwood J.
- Kloss H.
- Kolb E.
- Kralt K.
- Krauss M.D.
- Krim A.
- Kurath H.
- Kurath H.
- Lalonde A.
- Lamb W.K.
- Lewis G.J.
- Loch. C.
- Louder D.R.
- Louder D.R.
- Louder D.R.
- Loy W.G.
- Mather J.Y.
- McDavid R.I.
- McRae K.D.
- Meyer A.H.
- Morgan B.J.T.
- Nelson M.A.
- Nicholson N.L.
- Nicholson N.L.
- Nicholson R.
- Nicolaisen W.F.H.
- North D.J.
- Ochterlony J.
- Orton H.
- Orton H.
- Orton H.
- Orton H.
- Oukada L.
- Petyt K.M.
- Price G.
- Pryce W.T.R.
- Pryce W.T.R.
- Raup H.F.
- Ravenstein E.G.
- Reader's Digest Association
- Reed C.E.
- Reed C.E.
- Richards J.H.
- Rooney J.F.
- Rudnyckyi J.B.
- Sharp E.F.
- Shortridge J.R.
- Skeat W.W.
- Skene W.F.
- Sloan C.S.
- Smout T.C.
- Southall J.E.
- Stephenson D.B.
- Stewart D.G.
- Tarpley F.
- Thomas A.R.
- Thomas C.H.
- Thomas J.I.
- Thomas P.W.
- Thomas R.M.
- Trudgill P.
- US Bureau of the Census
- Vernex J.-C.
- Waddell E.
- Waddell E.
- Wagner H.
- Wakelin M.F.
- Warkentin J.
- Watkins T.A.
- Weir T.R.
- West R.C.
- Wilbur Zelinsky
- Williams C.H.
- Williams D.T.
- Williams S.W.
- Wilson L.R.
- Wood G.R.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Cannabinoids in neurodegeneration and neuroprotection
- Author
- A. Arévalo-Martin
- A. Berardelli
- A. Carlsson
- A. Doble
- A. Witting
- A.D. Sinor
- A.J. Hampson
- A.J. Hampson
- A.J. Hampson
- A.M. Malfait
- B. Liu
- B. Moosmann
- B. Reisberg
- C. Benito
- C. Blázquez
- C. ladecola
- C. Matute
- C. Mazzola
- C. Raman
- C. Sánchez
- C. Sánchez
- C.H. Polman
- C.J. Fowler
- C.J. Hillard
- C.J. Hillard
- C.M. Maier
- D. Baker
- D. Baker
- D. Baker
- D. Braida
- D. Gebremedhin
- D. Giulian
- D. Panikashvili
- D. Pitt
- D.A. Hafler
- D.F. Louw
- D.I. Graham
- E. Cattaneo
- E. Galea
- E. Lago de
- E. Molina-Holgado
- E. Nuñez
- E. Polazzi
- E. Sapp
- E. Schlicker
- E. Shohami
- E.J. Carrier
- E.K. Richfield
- E.M. Denovan-Wright
- E.N. Benveniste
- F. Aloisi
- F. Berrendero
- F. Blandini
- F. Mauler
- F. Molina-Holgado
- F. Molina-Holgado
- F.J. Vajda
- G. Battaglia
- G. Marsicano
- G. Marsicano
- G. Martino
- G. Pryce
- G. Rajkowska
- G.M. Rubanyi
- H.H. Hansen
- H.H. Hansen
- H.M. Gao
- H.S. Hansen
- H.S. Hansen
- I. Dusart
- I. Galve-Roperh
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Lastres-Becker
- I. Wirguin
- I.B. Adams
- J. Chemin
- J. Romero
- J. Romero
- J. Romero
- J. Romero
- J. Zajicek
- J.A. Klein
- J.A. Wagner
- J.J. Fernández-Ruiz
- J.L. Croxford
- J.M. Brotchie
- J.M. Brotchie
- J.M. Sullivan
- J.P. Frankel
- J.P. Meschler
- J.W. Brooks
- K. Kieburtz
- K. Mackie
- K. Mackie
- K. Pong
- K. Williams
- K.D. Sethi
- K.J. Page
- K.L. Jin
- K.R. Mbiller-Vahl
- L. Belayev
- L. Petrocellis De
- L. Volicer
- L. Walter
- L. Walter
- M. Glass
- M. Glass
- M. Gu
- M. Guzmán
- M. Guzmán
- M. Herkenham
- M. Maccarrone
- M. Saji
- M. Shen
- M. Stelt van der
- M. Stelt van der
- M. Stelt van der
- M. Strong
- M.C. Galas
- M.C. Sañudo-Peña
- M.D. Randall
- M.E. Abood
- M.R. Pazos
- M.T. Carri
- N. Bizat
- N. Eshhar
- N. Knoller
- N.G. Milton
- P. Consroe
- P. Eikelenboom
- P. Gubellini
- P. Mailleux
- P. Rieckmann
- P. Werner
- P.H. Chan
- P.H. Reddy
- P.J. Blount
- P.L. McGeer
- P.L. McGeer
- R. Mechoulam
- R. Mechoulam
- R. Tintner
- R.A. Puffenbarger
- R.B. Maccioni
- R.G. Coffey
- R.G. Pertwee
- R.I. Grundy
- R.I. Grundy
- R.J. Gagliardi
- R.L. Rodnitzky
- S. Ben-Shabat
- S. Parmentier-Batteur
- S. Schinelli
- S. Toulmond
- S.A. Deadwyler
- S.A. Factor
- S.D. McAllister
- S.D. Skaper
- S.M. Chou
- S.R. Smith
- T. Alexi
- T. Bisogno
- T. Gómez Pulgar Del
- T. Iuvone
- T. Nagatsu
- T. Nagayama
- T. Wyss-Coray
- T.B. Sherer
- T.M. Westlake
- T.W. Klein
- V. Janardhan
- V. Marzo Di
- V. Nadler
- V. Nadler
- V.W. Yong
- W.D. Lyman
- W.G. Kim
- W.R. Schabitz
- X. Pan
- Y. Chen
- Y. Chen
- Y. Waksman
- Y.P. Maneuf
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
Nectar chemistry
- Author
- A. Bruneau
- A. Bruneau
- A. Búrquez
- A. Dafni
- A. Erhardt
- A. Fahn
- A. Forcone
- A. Jakubska
- A. Juergens
- A. Shiraishi
- A. Sols
- A.B. Bolten
- A.B. Carroll
- A.G. Stephenson
- A.G. Villarreal
- A.J. Heyneman
- A.M.C. Davies
- A.R. Davis
- A.R. Davis
- A.R. Masters
- A.W. Robards
- B. Halliwell
- B. Hazslinsky
- B.-E. van Wyk
- B.J. Borrell
- B.K. Ehlers
- B.W. Hanny
- C. Carter
- C. Carter
- C. Carter
- C. Carter
- C. Carter
- C. Carter
- C. Carter
- C. Galen
- C. Griebel
- C. MartÃnez del Rio
- C. MartÃnez del Rio
- C. Pérez-Giraldo
- C. Torres
- C.A. Kearns
- C.A. Mullin
- C.E. Ecroyd
- C.E. Freeman
- C.E. Freeman
- C.E. Freeman
- C.L. Gass
- C.M. Herrera
- C.M. Passreiter
- C.N. Lotz
- D. Kleijn
- D. Natale
- D. Plepys
- D. Seigler
- D. Tholl
- D. Wolff
- D.A. Rowley
- D.C. Jeffrey
- D.E. Metzler
- D.F. Rhoades
- D.K. Sandhu
- D.M. Hansen
- D.W. Inouye
- D.W. Inouye
- D.W. Roubik
- E. Crane
- E. de la Barrera
- E. Gryj
- E. Omand
- E. Pacini
- E. Pichersky
- E.C. Kronestedt-Robards
- E.O. Guerrant
- E.R. Jaycox
- F. Bukatsch
- F. Ferreres
- F. Liu
- F.G. Stiles
- F.G. Stiles
- G. Bergström
- G. Gottsberger
- G. Gottsberger
- G. Heinrich
- G. Li
- G.D. Waller
- G.F. Smith
- G.G. Birch
- G.G. Bozzo
- G.H. Pyke
- G.L. Stebbins
- G.M. Loper
- G.W. Felton
- G.W. Frankie
- H. Dafni
- H. Ziegler
- H. Ziegler
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.G. Baker
- H.P. Rusterholz
- H.S. McTavish
- H.T. Horner
- H.W. Krenn
- I. Baker
- I.F. Radzevenchuk
- J. Alm
- J. Antonovics
- J. Lanza
- J. Pate
- J. Paul
- J. Pryce-Jones
- J. Sugiyama
- J.C. del Pozo
- J.E. Cresswell
- J.G. Kingsolver
- J.G. Kingsolver
- J.G. Zimmerman
- J.H. Brown
- J.L. Vesprini
- J.M. Olesen
- J.P. Cunningham
- J.R. Hagler
- J.R. Hagler
- J.S. Pate
- J.T. Knudsen
- K. Barnes
- K. Crailsheim
- K. Faegri
- K. Hansen
- K. Honda
- K.A. Leiss
- K.A. Lord
- K.A. Pivnick
- K.D. Holl
- K.S. Powell
- L. Bernardello
- L. Bernardello
- L. Chittka
- L. Fowden
- L. Galetto
- L. Galetto
- L. Galetto
- L. Galetto
- L. Galetto
- L.D. Harder
- L.L. Smith
- L.S. Adler
- L.S. Adler
- L.S. Adler
- M. Devoto
- M. Hammer
- M. Heil
- M. Mathlouthi
- M. Nepi
- M. Ordano
- M. Perret
- M. Perret
- M. Proctor
- M. Sazima
- M. Schwerdtfeger
- M. Tadey
- M. Zimmerman
- M. Zimmerman
- M.A. Aizen
- M.A. McKenna
- M.C. Castellanos
- M.C. Gardener
- M.C. Gardener
- M.C. Gardener
- M.E. Bitterman
- M.I. Gil
- M.J. del Baño
- M.S. Percival
- M.W. Langenberger
- N. Dudareva
- N. Hrassnigg
- N. Singaravelan
- N.M. Williams
- O.A. Zauralov
- O.E. PrÅ·s-Jones
- P.A. Fleming
- P.C. Andersen
- P.G. Kevan
- P.G. Willmer
- P.G.L. Klinkhamer
- P.J. Landolt
- P.S. Nobel
- R. Beutler
- R. Bleiweiss
- R. Naef
- R. Pressey
- R. Scogin
- R. Wyatt
- R.A. Raguso
- R.A. Raguso
- R.C. Plowright
- R.C. Plowright
- R.C. Prince
- R.J. Barker
- R.J. Barker
- R.L. Kaczorowski
- R.M.R. Barclay
- R.V. Barbehenn
- R.W. Brosemer
- R.W. Thornburg
- R.W. Thorp
- S. Ahmad
- S. Ahmad
- S. Andersson
- S. Ankri
- S. Ankri
- S. Bogdanov
- S. Chandra
- S. Deachathai
- S. Jackson
- S. Koptur
- S. Micheu
- S. Patiño
- S. Petit
- S. Restrepo
- S. Vogel
- S. Wacht
- S.-Q. Huang
- S.A. Corbet
- S.A. Corbet
- S.A. Corbet
- S.A. Corbet
- S.A. Corbet
- S.A. Johnson
- S.A. Scobell
- S.D. Bradshaw
- S.D. Johnson
- S.D. Johnson
- S.G. Weller
- S.L. Buchmann
- S.M. Chapotin
- S.M. Hiebert
- S.M.S. Naqvi
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- S.W. Nicolson
- T. Bubán
- T. Cotti
- T. Petanidou
- T. Petanidou
- T. Petanidou
- T. Petanidou
- T. Petanidou
- T. Swain
- T.B. Stone
- T.H. Roulston
- U. Lüttge
- U. Lüttge
- V. Grant
- V.A. Hilder
- V.G. Dethier
- V.R. Chalcoff
- W. Völkl
- W. Zalewski
- W.J. Dress
- W.J. Elisens
- W.J. Peumans
- Y. Ozoe
- Y. Rabhé
- Z. Sroka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study