Responding to the Impending Repossessions Crisis

This paper was commissioned by Communities and Local Government in November 2008 in response to the rise in repossessions. It addresses the macroeconomic and social impacts of repossessions and makes recommendations for government action

Pathos and patter in real estate parlance

This paper presents the first systematic analysis of estate agent language and employs Aristotle’s ponderings on the art of persuasion as a means of classifying the peculiar parlance of property peddlers. “Des. Res.”, “rarely available”, “viewing essential” – these are all part of the peculiar parlance of housing advertisements. The question is whether the selling agent’s penchant for rhetoric is uniform across a single urban system or whether there are variations, even within a relatively limited geographical area. We are also interested in how the use of superlatives varies over the market cycle. For example, are estate agents more inclined to use hyperbole when the market is buoyant or when it is flat? This paper attempts to answer these questions by applying textual analysis to a unique dataset of 49,926 records of real estate transactions in the West of Scotland over the period 1999 to 2006. Our analysis has implications for our understanding of the agency behaviour of housing market professionals and endeavours to open up a new avenue of research into the market-impact of rhetoric in the language of selling

Quantification of neurodegeneration by measurement of brain-specific proteins

Quantification of neurodegeneration in animal models is typically assessed by time-consuming and observer-dependent immunocytochemistry. This study aimed to investigate if newly developed ELISA techniques could provide an observer-independent, cost-effective and time-saving tool for this purpose. Neurofilament heavy chain (NfH(SM135)), astrocytic glial fibrillary acidic protein (GFAP), S100B and ferritin, markers of axonal loss, gliosis, astrocyte activation and microglial activation, respectively, were quantified in the spinal cord homogenates of mice with chronic relapsing experimental allergic encephalomyelitis (CREAE, n=8) and controls (n=7). Levels of GFAP were found to be threefold elevated in CREAE (13 ng/mg protein) when compared to control animals (4.5 ng/mg protein, p<0.001). The inverse was observed for NfH(SM135) (21 ng/mg protein vs. 63 ng/mg protein, p<0.001), ferritin (542 ng/mg protein vs. 858 ng/mg protein, p<0.001) and S100B (786 ng/mg protein vs. 2080 ng/mg protein, N.S.). These findings were confirmed by immunocytochemistry, which demonstrated intense staining for GFAP and decreased staining for NfH(SM135) in CREAE compared to control animals. These findings indicate that axonal loss and gliosis can be estimated biochemically using the newly developed ELISA assays for NfH(SM135) and GFAP. These assays may facilitate the quantification of pathological features involved in neurodegeneration

Factors affecting environmental attitudes and volunteering in England and Wales

This paper investigates the demographic, social, political and religious factors that affect people’s attitudes to the environment and their involvement in environmental volunteering in England and Wales, using data from four waves of the Home Office Citizenship Survey between 2003 and 2009. Approximately 14,000 people were included in each wave of the survey, with around 85%-90% of people having a positive attitude to the environment, while 7%-8% were involved in volunteering. The data were analysed using logistic regression models. Covariates included sex, ethnicity, age, income, education, religion and region. We found that positive attitude and volunteering increased up to the age of 65 before decreasing sharply. People on middling incomes between £20k and £60k were the most likely to have positive environmental attitude and activity. We found no evidence of behavioural change—the results on both environmental attitudes and volunteering remained stable across all four waves of the survey

The Classical Relativistic Quark Model in the Rest-Frame Wigner-Covariant Coulomb Gauge

The system of N scalar particles with Grassmann-valued color charges plus the color SU(3) Yang-Mills field is reformulated on spacelike hypersurfaces. The Dirac observables are found and the physical invariant mass of the system in the Wigner-covariant rest-frame instant form of dynamics (covariant Coulomb gauge) is given. From the reduced Hamilton equations we extract the second order equations of motion both for the reduced transverse color field and the particles. Then, we study this relativistic scalar quark model, deduced from the classical QCD Lagrangian and with the color field present, in the N=2 (meson) case. A special form of the requirement of having only color singlets, suited for a field-independent quark model, produces a ``pseudoclassical asymptotic freedom" and a regularization of the quark self-energy.Comment: 81 pages, RevTe

Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis

Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS. Therefore, it was interestingly to find that current MS-treatments, believed to act via T cell inhibition, including: beta-interferons, glatiramer acetate, cytostatic agents, dimethyl fumarate, fingolimod, cladribine, daclizumab, rituximab/ocrelizumab physically, or functionally in the case of natalizumab, also depleted CD19+, CD27+ memory B cells. This depletion was substantial and long-term following CD52 and CD20-depletion, and both also induced long-term inhibition of MS with few treatment cycles, indicating induction-therapy activity. Importantly, memory B cells were augmented by B cell activating factor (atacicept) and tumor necrosis factor (infliximab) blockade that are known to worsen MS. This creates a unifying concept centered on memory B cells that is consistent with therapeutic, histopathological and etiological aspects of MS

Theorising the causal impacts of social frontiers: the social and psychological implications of discontinuities in the geography of residential mix

Until very recently, the question of how residents might be affected by the gradient of neighbourhood boundaries—whether these boundaries are abrupt or gradual—has remained largely absent from mainstream segregation research. Yet, theoretical and empirical findings emerging from recent studies suggests the impacts could be profound and far-reaching. This paper seeks to provide a conceptual foundation for understanding such effects. We focus on the concept of “social frontiers”: spatial discontinuities in the geography of residential mix which occur when community boundaries are abrupt. Drawing on insights from cognate disciplines, we develop a theory of social frontier impacts that articulates their potential importance in limiting and shaping contact between neighbouring communities, exacerbating territorial conflict, and ultimately affecting the psychological wellbeing and life course outcomes of those living at the frontier. We present our thesis as a series of propositions and corollaries, and reflect on the implications for empirical research

The conflicting geographies of social frontiers: exploring the asymmetric impacts of social frontiers on household mobility in Rotterdam

Social frontiers arise when there are sharp differences in the demographic composition of adjacent communities. This paper provides the first quantitative study of their impact on household mobility. We hypothesise that conflicting forces of white flight and territorial allegiance lead to asymmetrical effects, impacting residents on one side of the frontier more than the other due to differences in the range of housing options available to different groups, and different symbolic interpretations of the frontier. Using Dutch registry data for the city of Rotterdam we identify ethnic social frontier locations using a Bayesian spatial model (Dean et al 2019), exploiting the data’s one hundred metre resolution to estimate frontiers at a very small spatial scale. regression analysis of moving decisions finds that the ethnic asymmetry of the frontier matters more than ethnicity of individual households. On the ethnic minority side of the frontier, households of all ethnicities in the 28-37 age range have reduced probability of moving compared to non-frontier parts of the city. The opposite is true on the Dutch native side of the frontier. We supplement this analysis with flow models which again find strong frontier effects. Our findings illustrate how the study of social frontiers can shed light on local population dynamics and neighbourhood change