Clinical, laboratory and radiological features of RsV-bronchiolitis in premature infants [клинико-лабораторные и рентгенологические особенности рсв-бронхиолита у недоношенных детей]

Introduction: Respiratory syncytial viral (RSV) bronchiolitis is a severe respiratory lesion, which is often found among premature infants, but has not been sufficiently studied in this group of newborns. The aim of the study was to analyze clinical and laboratory features of the course of RSV infection in premature infants. Materials and methods. Clinical, laboratory and x-ray examination of 40 pre mature infants with RSV-bronchiolitis verified by immunofluorescence reaction and polymerase chain reaction was carried out. Research result. Among patients with RSV-bronchiolitis, children with gestational age of 29–32 and 33–35 weeks and body weight of 1000–1499 and 1500–2499 grams predominate significantly. In patients, the disease was often accompanied by a lack of temperature, symptoms of bronchial obstruction, crepitation, development of respiratory failure II–III CT in 77,5% of cases, severe need for oxygen therapy (80%), hospitalization in ORNT (50%). Conclusion. Premature infants constitute a risk group for the development of RSV bronchiolitis. © 2019 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved

Клинико-лабораторные и рентгенологические особенности РСВ-бронхиолита у недоношенных детей

Introduction: Respiratory syncytial viral (RSV) bronchiolitis is a severe respiratory lesion, which is often found among premature infants, but has not been sufficiently studied in this group of newborns. The aim of the study was to analyze clinical and laboratory features of the course of RSV infection in premature infants. Materials and methods. Clinical, laboratory and x-ray examination of 40 pre mature infants with RSV-bronchiolitis verified by immunofluorescence reaction and polymerase chain reaction was carried out. Research result. Among patients with RSV-bronchiolitis, children with gestational age of 29-32 and 33-35 weeks and body weight of 1000-1499 and 1500-2499 grams predominate significantly. In patients, the disease was often accompanied by a lack of temperature, symptoms of bronchial obstruction, crepitation, development of respiratory failure II-III CT in 77,5% of cases, severe need for oxygen therapy (80%), hospitalization in ORNT (50%). Conclusion. Premature infants constitute a risk group for the development of RSV bronchiolitis.Введение: респираторно-синцитиальный вирусный (РСВ) бронхиолит - тяжелое поражение органов дыхания, который часто встречается среди недоношенных детей, но недостаточно изучен в данной группе новорожденных. Цель: анализ клинических и лабораторных особенностей течения РСВ-инфекции у недоношенных детей. Материалы и методы: проведено клиническое, лабораторное и рентгенологическое обследование 40 недоношенных детей с РСВ-бронхиолитом, верифицированным реакцией иммунофлюоресценции и полимеразной цепной реакцией. Результаты: среди больных РСВ-бронхиолитом достоверно преобладают дети с гестационным возрастом 29-32 и 33-35 недель и массой тела 1000-1499 и 1500-2499 г. У пациентов заболевание часто сопровождалось отсутствием температуры, симптомами бронхиальной обструкции, крепитации, развитием дыхательной недостаточности II-III. ст в 77,5% случаев, тяжелым течением, потребностью в кислородотерапии (80%), госпитализации в ОРНТ (50%). Заключение: недоношенные дети представляют группу риска по развитию РСВ-бронхиолита

Информативность антеи интранатальных факторов риска развития бронхолегочной дисплазии у недоношенных новорожденных

Aim of the study. To identify the leading antenatal and intranatal risk factors for bronchopulmonary dysplasia based on the analysis of their prevalence and information contentMaterials and methods. We performed a prospective follow-up of 124 infants of gestational age of less than 32 weeks with the classical form of bronchopulmonary dysplasia (study group). The control group included 119 newborns with gestational age of less than 32 weeks without bronchopulmonary dysplasia. The parents of the compared groups were questioned, with the following assessment of the prevalence and informative value of antenatal and intranatal risk factors. Results. The leading antenatal and intranatal risk factors for the development of bronchopulmonary dysplasia are: acute respiratory viral infection in II-III trimester, threatened miscarriage, intrauterine growth retardation, Apgar score at the 1st (3 or less) and 5th minute (5 or less), body weight of less than 1400g at birth, body length less than 36 cm at birth, cesarean section, more then 6-hours waterless period. Conclusion. The combination of these intranatal and antenatal risk factors can be attributed to a group with high risk of bronchopulmonary dysplasia.Цель исследования. Выделение ведущих анте- и интранатальных факторов риска развития бронхолегочной дисплазии на основе анализа их распространенности и информативности.Материал и методы. Проведено проспективное наблюдение за 124 младенцами гестационного возраста менее 32 нед с классической формой бронхолегочной дисплазии (основная группа). Контролем служили 119 новорожденных со сроком гестации менее 32 нед без бронхолегочной дисплазии. На основе анкетирования проведен опрос родителей сравниваемых групп с последующей оценкой распространенности и информативности анте- и интранатальных факторов риска. Результаты. Ведущими анте- и интранатальными факторами риска развития бронхолегочной дисплазии служат присоединение острой респираторной вирусной инфекции во II-III триместре, угроза прерывания беременности, задержка внутриутробного развития плода, низкая оценка по шкале Апгар на 1-й (3 балла и менее) и 5-й (5 баллов и менее) минутах, масса тела при рождении менее 1400 г, длина тела при рождении менее 36 см, выполнение кесарева сечения, безводный промежуток более 6 ч. Заключение. Сочетание указанных интра- и антенатальных факторов дает основание отнести новорожденных к высокой группе риска формирования бронхолегочной дисплазии

Information value of ante- And intranatal risk factors for bronchopulmonary dysplasia in preterm newborns [Информативность анте- и интранатальных факторов риска развития бронхолегочной дисплазии у недоношенных новорожденных]

Aim of the study. To identify the leading antenatal and intranatal risk factors for bronchopulmonary dysplasia based on the analysis of their prevalence and information content Materials and methods. We performed a prospective follow-up of 124 infants of gestational age of less than 32 weeks with the classical form of bronchopulmonary dysplasia (study group). The control group included 119 newborns with gestational age of less than 32 weeks without bronchopulmonary dysplasia. The parents of the compared groups were questioned, with the following assessment of the prevalence and informative value of antenatal and intranatal risk factors. Results. The leading antenatal and intranatal risk factors for the development of bronchopulmonary dysplasia are: acute respiratory viral infection in II-III trimester, threatened miscarriage, intrauterine growth retardation, Apgar score at the 1st (3 or less) and 5th minute (5 or less), body weight of less than 1400g at birth, body length less than 36 cm at birth, cesarean section, more then 6-hours waterless period. Conclusion. The combination of these intranatal and antenatal risk factors can be attributed to a group with high risk of bronchopulmonary dysplasia. © 2019 National Academy of Pediatric Science and Innovation. All rights reserved