Novel methods for axial fan impeller geometry analysis and experimental investigations of the generated swirl turbulent flow

Geometry analysis of the axial fan impeller, experimentally obtained operating characteristics and experimental investigations of the turbulent swirl flow generated behind the impeller are presented in this paper. Formerly designed and manufactured, axial fan impeller blade geometry (originally designed by Prof Dr-Ing. Z. Protic(dagger)) has been digitized using a three-dimensional scanner. In parallel, the same impeller has been modeled by beta version software for modeling axial turbomachines, based on modified classical calculation. These results were compared. Afterwards, the axial fan operating characteristics were measured on the standardized test rig in the Laboratory for Hydraulic Machinery and Energy Systems, Faculty of Mechanical Engineering, University of Belgrade. Optimum blade impeller position was determined on the basis of these results. Afterwards, impeller with angle 22 without outlet vanes, was positioned in a circular pipe. Rotational speed has been varied in the range from 500 till 2500 rpm. Reynolds numbers generated in this way, calculated for axial velocity component, was in the range from 0.68.10(5) till 2.5.10(5). Laser Doppler anemometry measurements and stereo particle image velocimetry measurements of the three-dimensional velocity field in the swirl turbulent fluid flow behind the axial fan have been performed for each regime. Obtained results point out extraordinary complexity of the structure of generated three-dimensional turbulent velocity fields

Bioetička pitanja u vezi sa sigurnošću lijekova kod vulnerabilnih skupina

U cilju procjene stavova studenata medicine u odnosu na sudjelovanje vulnerabilnih subjekata u kliničkim ispitivanjima, proveli smo studiju presjeka (N = 174, studenti dodiplomskih studija Medicinskog fakulteta, Univerziteta u Beogradu). Studija presjeka provedena je tijekom jednog dana, na slučajno odabranim uzorcima studenata 3. godine (95/493 studenata) i 6. godine (79/510 studenata). Ukupno je odgovoreno na 83 % postavljenih pitanja. Rezultati studije pokazali su da studenti našeg fakulteta uglavnom nisu voljni sudjelovati kao dobrovoljci u kliničkim ispitivanjima, niti raditi u nehigijenskim romskim naseljima. Studenti su naglasili važnost dobivanja pristanka i djeteta i roditelja za sudjelovanje u kliničkom ispitivanju. Kada su u pitanju ispitivanja novih lijekova na populaciji starijih dementnih bolesnika, većina ispitanika smatra da informirani pristanak treba biti sličan pristanku za bilo koju drugu populaciju. U zaključku, tekući medicinski kurikulum treba biti više usmjeren na procjenu sigurnosti lijekova u vulnerabilnim skupinama. Posebno je potrebno unaprijediti rad s pripadnicima marginaliziranih skupina (npr. dodatna edukacija, posjeti nehigijenskim romskim naseljima i zajednički projekti)

Patient autonomy and informed consent in critically lll

Patient autonomy has been a cornerstone of contemporary clinical ethics since the Nuremberg trial, especially in American school of bioethics. Topic: Patient autonomy has been defined in the Nuremberg Code, and re-defined in the Declaration of Helsinki, Belmont Report and Barcelona Declaration. Founders and followers of the rights-oriented bioethics (for example, Hellegers, Beauchamp and Childers) have established and promoted the patient autonomy as the main principle of bio(medical) ethics since 1970s. However, there is a lot of controversy surrounding such a principle, especially in vulnerable patients. We aimed at evaluating the real meaning and value of patient autonomy in critical care settings regarding the communication between health workers and their patients and families. Conclusion: Protection of patients autonomy in critically ill is a complex issue. Careful benefit-risk assessment is needed in order to find the most appropriate way of obtaining the informed consent, proxy consent or to omit or delay it

NOVEL METHODS FOR AXIAL FAN IMPELLER GEOMETRY ANALYSIS AND EXPERIMENTAL INVESTIGATIONS OF THE GENERATED SWIRL TURBULENT FLOW

Geometry analysis of the axial fan impeller, experimentally obtained operating characteristics and experimental investigations of the turbulent swirl flow generated behind the impeller are presented in this paper. Formerly designed and manufactured, axial fan impeller blade geometry (originally designed by Prof. Dr-Ing. Z. Protić†) has been digitized using a three-dimensional (3D) scanner. In parallel, the same impeller has been modeled by beta version software for modeling axial turbomachines, based on modified classical calculation. These results were compared. Then, the axial fan operating characteristics were measured on the standardized test rig in the Laboratory for Hydraulic Machinery and Energy Systems, Faculty of Mechanical Engineering, University of Belgrade. Optimum blade impeller position was determined on the basis of these results. Afterwards, the impeller with optimum angle, without outlet vanes, was positioned in a circular pipe. Rotational speed has been varied in the range from 500 till 2500rpm. Reynolds numbers generated in this way, calculated for axial velocity component, were in the range from 0,8·105 till 6·105. LDA (Laser Doppler Anemometry) measurements and stereo PIV (Particle Image Velocimetry) measurements of the 3D velocity field in the swirl turbulent fluid flow behind the axial fan have been performed for each regime. Obtained results point out extraordinary complexity of the structure of generated 3D turbulent velocity fields

CARD15 gene polyrnorphisms in Serbian patients with Crohn's disease: genotype-phenotype analysis

Objective Genetic heterogeneity and incomplete phenotype penetrance complicate genetic analysis of Crohn's disease (M. Studies in western Europe have shown that CARD15 polymorphisms increase susceptibility to CD, but frequencies vary within different European populations. The aim here was to evaluate the prevalence of CARD15 mutations and their phenotypic correlation in a Serbian population. Materials and methods 131 patients with CD, 65 patients with ulcerative colitis, and 88 healthy controls were genotyped for three common mutations (R702W, G908R, Leu1007insC) by PCR-restriction fragment length polymorphism. chi(2) and Student's t-test were used for statistical assessment. Results At least one CARD15 disease-associated allele was found in 35.11 % patients with CD, 14.77% of healthy controls (P=0.001), and 7.69% patients with ulcerative colitis (P= 0.0001). The L1007fs mutation showed a significant association with CD (P lt 0.0001). The frequency of R702W mutant allele was almost equal in the control group and CD patients Univariate analyses established that CARD15 carriers had a significantly higher risk of isolated ileal location [P=0.042; odds ratio (OR) 2.30; 95% confidence interval (CI): 1.02-5.191, fibrostenotic behavior (P lt 0.0001; OR 9.86; 95% CI: 4.29-22.62), surgical resection (P=0.036; OR 2.2; CI, 1.046-4.626), and earlier onset of disease (P=0.026). Conclusion This study confirms that CARD15 carriers, especially L1007fs mutants, in central Europeans have an increased risk of CD and it is associated with earlier onset, ileal, fibrostenotic disease and a higher risk of surgery. Any influence of latitude is not matched by an east-west divide on the genotype frequency and phenotype of CD within Europe