25 research outputs found
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
Crystal structures of protease/inhibitor complexes guided optimization of the buried nonpolar surface area thereby maximizing hydrophobic binding. The resulting potent tripeptide inhibitor is in clinical trials
Substitution of the Conserved Arg-Tyr Dyad Selectively Disrupts the Hydrolysis Phase of the IMP Dehydrogenase Reaction
An Insight to the Dynamics of Conserved Water Molecular Triad in IMPDH II (Human): Recognition of Cofactor and Substrate to Catalytic Arg 322
Separating the concerns of distributed deployment and dynamic composition in internet application systems
The Internet is currently evolving from a global information network into a distributed application system. For example, some Internet applications are based on executing remote services which have been previously installed on possibly multiple Internet nodes, whereas parts of other Internet applications are dynamically moved from several remote nodes to be executed on a single node. In this paper, we focus on the related problem of how the parts of an Internet application that have been independently deployed on multiple Internet nodes can be transparently located, seamlessly retrieved and dynamically composed on a particular node by request. Vie propose a novel deployment and composition approach using so called modules and module federations and show how to separate the logical application composition from the physical module deployment. The realization of our proposal in Java and C++ is presented and the use of the approach in ongoing research projects is demonstrated