Hot Carrier Controlled Nitrogen Fixation Reaction in Metal-Free Boron-Anchored Aza-COF: Insight from Nonadiabatic Molecular Dynamics Simulation

Designing highly efficient photocatalysts for the production of renewable energy is a challenging task that necessitates simultaneous control of chemical activity and photocarrier dynamics for a particular reaction. To this end, we have investigated the catalytic mechanism and real-time photocarrier dynamics of the nitrogen reduction reaction (NRR) at the metal-free boron-functionalized 2D aza-COF (B-aza-COF), an inexpensive and environmentally friendly semiconductor. By employing density functional theory (DFT) and time-dependent ab initio nonadiabatic molecular dynamics simulation, we have investigated the electronic structure, light harvesting ability, free energy change, and dynamics of photoexcited carriers. Our calculated results reveal that the gas phase N2 molecule can be effectively reduced into NH3 on B-aza-COF under UV–visible light. Therefore, our investigation on the design of efficient photocatalysts for the nitrogen reduction reaction (NRR) provides a cost-effective opportunity for the sustainable production of NH3

Dual glyoxalase-1 and β-klotho gene-activated scaffold reduces methylglyoxal and reprograms diabetic adipose-derived stem cells: prospects in improved wound healing

Tissue engineering approaches aim to provide biocompatible scaffold supports that allow healing to progress often in healthy tissue. In diabetic foot ulcers (DFUs), hyperglycemia impedes ulcer regeneration, due to complications involving accumulations of cellular methylglyoxal (MG), a key component of oxidated stress and premature cellular aging which further limits repair. In this study, we aim to reduce MG using a collagen-chondroitin sulfate gene-activated scaffold (GAS) containing the glyoxalase-1 gene (GLO-1) to scavenge MG and anti-fibrotic β-klotho to restore stem cell activity in diabetic adipose-derived stem cells (dADSCs). dADSCs were cultured on dual GAS constructs for 21 days in high-glucose media in vitro. Our results show that dADSCs cultured on dual GAS significantly reduced MG accumulation (-84%; p </p

Dual glyoxalase-1 and β-klotho gene-activated scaffold reduces methylglyoxal and reprograms diabetic adipose-derived stem cells: prospects in improved wound healing

Tissue engineering approaches aim to provide biocompatible scaffold supports that allow healing to progress often in healthy tissue. In diabetic foot ulcers (DFUs), hyperglycemia impedes ulcer regeneration, due to complications involving accumulations of cellular methylglyoxal (MG), a key component of oxidated stress and premature cellular aging which further limits repair. In this study, we aim to reduce MG using a collagen-chondroitin sulfate gene-activated scaffold (GAS) containing the glyoxalase-1 gene (GLO-1) to scavenge MG and anti-fibrotic β-klotho to restore stem cell activity in diabetic adipose-derived stem cells (dADSCs). dADSCs were cultured on dual GAS constructs for 21 days in high-glucose media in vitro. Our results show that dADSCs cultured on dual GAS significantly reduced MG accumulation (-84%; p </p

CHW cadres referred to in this paper.

CHW cadres referred to in this paper.</p

Thematic framework for synthesis.

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Country development and health system status [31–33].

Country development and health system status [31–33].</p

Reports included in the synthesis.

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Projects and reports used for the synthesis.

Projects and reports used for the synthesis.</p

Percentage of satisfied/confident participants, with PCOS subjects vs non-PCOS subjects.

Percentage of satisfied/confident participants, with PCOS subjects vs non-PCOS subjects.</p

Binary logistics regression analysis assessing whether PCOS, high BMI and body shape had impact on satisfaction/confidence level of the participants.

Binary logistics regression analysis assessing whether PCOS, high BMI and body shape had impact on satisfaction/confidence level of the participants.</p