Исследование психометрических качеств опросников Minnesota LHF Q, MacNew Heart Disease HRQL и MOS SF-36 у больных с хронической сердечной недостаточностью ишемического происхождения

Department of Chronic Heart Failure, Institute of Cardiology, State University of Medicine and Pharmacy „Nicolae Testemitanu”, Chisinau, Republic of MoldovaUntil now there have not been validated instruments that assess the quality of life in patients with cardiovascular disease in the Republic of Moldova. The 6 stages of Minnesota LHF Q, MacNew Heart Disease HRQL and MOS SF-36 questionnaires were validated, followed by a pilot study – 337 patients with ischemic chronic heart failure in II-III NYHA functional classes. To determine the psychometric qualities of the questionnaires we performed a test-retest method looking at correlations between the components of the questionnaires and quality of life indices, which were analyzed according to the age, sex, living environment, and studies. Our results demonstrated the questionnaires’ reliability and validity through the indication of linguistic validation that had been carried out successfully. Thus, it can be a methodological basis for future clinical trials in the Republic of Moldova.В настоящее время в Республике Молдова инструменты для оценки качества жизни пациентов с сердечно-сосудистой патологией не валидированы. Нами были выполнены все 6 этапов валидации трёх опросников (Minnesota LHF Q, MacNew Heart Disease HRQL и MOS SF36), с последующим проведением пилотного исследования – 337 пациентов с сердечной недостаточностью (ФК II-III NYHA) ишемического происхождения. Чтобы определить психометрические качества опросников было проведено двойное тестирование пациентов, корреляции между компонентами опросников, были проанализированы параметры качества жизни в зависимости от возраста, пола, условий жизни, наличия высшего образования. Полученные результаты продемонстрировали надежность и валидность опросников. Таким образом, проведение данной валидации составит методологическую основу для последующего проведения в нашей стране сравнимых клинических исследований в области кардиологии

Влияние гиполипидемической длительной терапии на некоторые факторы риска пациентов со старым инфарктом миокарда и сахарным диабетом второго типа

Department of Chronic Heart Failure, Institute of Cardiology, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaScopul studiului. Determinarea influenţei tratamentului hipolipemiant de durată asupra unor factori de risc la bolnavii cu infarct miocardic vechi şi diabet zaharat tip 2. Material şi metode În studiu au fost incluşi 54 de pacienţi cu Q-Infarct miocardic vechi şi diabet zaharat tip 2 (vârsta medie de 58,88 ± 0,92 ani), dintre care 31 de bărbaţi şi 23 de femei. Pacienţii au fost divizaţi în 2 grupuri: I grup – pacienţi cu Q-Infarct miocardic vechi şi diabet zaharat tip 2, care au administrat tratament standard şi tratament hipolipemiant cu Lovastatină (doza medie – 33,15 mg/zi), timp de 1 an, şi al II grup – pacienţi cu Q-Infarct miocardic vechi şi diabet zaharat tip 2, care au administrat numai tratament standard. Corecţia glicemiei a fost efectuată cu Glibenclamid (doza medie – 7,7 mg/zi). La toţi pacienţii a fost efectuată lipidograma (cu determinarea colesterolului total, trigliceridelor, HDL-colesterolului, LDL-colesterolului), fibrinogenul, proteina C-reactivă şi aprecierea grosimii intima-media a arterei carotide, conform metodei propuse de Pignoli. Rezultate Pacienţii cu infarct miocardic vechi şi diabet zaharat tip 2 au valori înalte ale colesterolului total, trigliceridelor, LDLcolesterolului, proteinei C-reactive şi indicele intima-media. Administrarea tratamentului hipolipemiant de durată a redus nivelul colesterolului total cu 28,41% (p < 0,01), trigliceridelor - cu 17,96 % (p < 0,05), LDL-colesterolului - cu 31,49% (p < 0,001), proteina C-reactivă - cu 18,46% (p < 0,05), fibrinogen - cu 20,41% (p < 0,01) şi indicele intima-media - cu 13,91% (p < 0,05). Pe fundal de dietă hipolipemiantă a existat o tendinţă de majorare a nivelului proteinei C-reactive, a fibrinogenului şi indicelui intima-media, dar statistic nesemnificativ. Datele sunt prezentate în tabelul. 1. Concluzie Tratamentul hipolipemiant de durată este efectiv în reducerea factorilor de risc la bolnavii cu infarct miocardic vechi şi diabet zaharat tip 2

Исследование качества жизни у больных с хронической сердечной недостаточностью ишемического происхождения с систолической дисфункцией или с сохраненной функцией левого желудочка

Institute of Cardiology, Department of Chronic Heart Failure, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaThe aim of this study was to determine changes in quality of life in patients with chronic HF in relation to the degree of LV systolic dysfunction and NYHA functional class. The study included 337 patients with ischemic heart failure, functional class NYHA II and III. All patients included were Romanian-speaking. To determine the quality of life in the study population, three questionnaires were used (validated version in Romanian): Minnesota Living with Heart Failure Questionnaire (Minnesota LHF Q), Mac New Heart Disease HRQL questionnaire and MOS-SF-36 questionnaire, short form. It Significant differences in quality of life between groups of patients with NYHA functional class II and III were identified after the application of all three questionnaires. In groups of patients with and without LV systolic dysfunction, application of Minnesota and MacNew questionnaires did not determine significant differences between groups in quality of life indices. And, the application of the generic SF-36 questionnaire has highlighted that physical functioning and pain indices and total physical component were more favorable in patients without LV systolic dysfunction. Thus, differences of quality of life were more evident in groups of patients divided according NYHA functional class than in groups of patients with or without LV systolic dysfunction.Целью исследования было в определении качества жизни у пациентов с хронической сердечной недостаточностью (ХСН) в зависимости от степени систолической дисфункции левого желудочка и функционального класса (ФК) NYHA. В исследование было включено 337 пациентов с сердечной недостаточностью (ФК II - III NYHA) ишемического происхождения. Для определения качества жизни были использованы 3 опросника (Minnesota LHF Q, MacNew Heart Disease HRQL и MOS SF-36). Статистически достоверные различия качества жизни были определены при использовании 3 опросников в группах больных разделенных в зависимости от ФК NYHA. При использовании опросников Minnesota LHF Q и MacNew, достоверные различия качества жизни в группах с нормальной функцией ЛЖ и с систолической дисфункцией ЛЖ не были определены. При применении вопросника SF-36 было установлено, что физическое функционирование, индекс боли и общий физический компонент были более благоприятными в группе пациентов с сохраненной функцией ЛЖ. Таким образом, различия в качестве жизни были более очевидны в группе больных, разделенных в зависимости от ФК NYHA, чем в группах больных с систолической дисфункцией ЛЖ или без нее

Masonry dams : analysis of the historical profiles of Sazilly, Delocre and Rankine

The significant advances in masonry dam design that took place in the second half of the 19th century are analyzed and discussed within the context of the historical development of dam construction. Particular reference is made to the gravity dam profiles proposed by Sazilly, Delocre and Rankine, who pioneered the application of engineering concepts to dam design, basing the dam profile on the allowable stresses for the conditions of empty and full reservoir. These historical profiles are analyzed taking into consideration the present safety assessment procedures, by means of a numerical application developed for this purpose, based on limit analysis equilibrium methods, which considers the sliding failure mechanisms, the most critical for these structures. The study underlines the key role of uplift pressures, which was only addressed by Lévy after the accident of Bouzey dam, and provides a critical understanding of the original design concepts, which is essential for the rehabilitation of these historical structures.This work has been funded by FCT (Portuguese Foundation for Science and Technology) through the PhD grant SFRH/BD/43585/2008, for which the first author is grateful

Scientific access into Mercer Subglacial Lake: scientific objectives, drilling operations and initial observations

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Priscu, J. C., Kalin, J., Winans, J., Campbell, T., Siegfried, M. R., Skidmore, M., Dore, J. E., Leventer, A., Harwood, D. M., Duling, D., Zook, R., Burnett, J., Gibson, D., Krula, E., Mironov, A., McManis, J., Roberts, G., Rosenheim, B. E., Christner, B. C., Kasic, K., Fricker, H. A., Lyons, W. B., Barker, J., Bowling, M., Collins, B., Davis, C., Gagnon, A., Gardner, C., Gustafson, C., Kim, O-S., Li, W., Michaud, A., Patterson, M. O., Tranter, M., Ryan Venturelli, R., Trista Vick-Majors, T., & Elsworth, C. Scientific access into Mercer Subglacial Lake: scientific objectives, drilling operations and initial observations. Annals of Glaciology, 62(85–86), (2021): 340–352, https://doi.org/10.1017/aog.2021.10.The Subglacial Antarctic Lakes Scientific Access (SALSA) Project accessed Mercer Subglacial Lake using environmentally clean hot-water drilling to examine interactions among ice, water, sediment, rock, microbes and carbon reservoirs within the lake water column and underlying sediments. A ~0.4 m diameter borehole was melted through 1087 m of ice and maintained over ~10 days, allowing observation of ice properties and collection of water and sediment with various tools. Over this period, SALSA collected: 60 L of lake water and 10 L of deep borehole water; microbes >0.2 μm in diameter from in situ filtration of ~100 L of lake water; 10 multicores 0.32–0.49 m long; 1.0 and 1.76 m long gravity cores; three conductivity–temperature–depth profiles of borehole and lake water; five discrete depth current meter measurements in the lake and images of ice, the lake water–ice interface and lake sediments. Temperature and conductivity data showed the hydrodynamic character of water mixing between the borehole and lake after entry. Models simulating melting of the ~6 m thick basal accreted ice layer imply that debris fall-out through the ~15 m water column to the lake sediments from borehole melting had little effect on the stratigraphy of surficial sediment cores.This material is based upon work supported by the US National Science Foundation, Section for Antarctic Sciences, Antarctic Integrated System Science program as part of the interdisciplinary (Subglacial Antarctic Lakes Scientific Access (SALSA): Integrated study of carbon cycling in hydrologically-active subglacial environments) project (NSF-OPP 1543537, 1543396, 1543405, 1543453 and 1543441). Ok-Sun Kim was funded by the Korean Polar Research Institute. We are particularly thankful to the SALSA traverse personnel for crucial technical and logistical support. The United States Antarctic Program enabled our fieldwork; the New York Air National Guard and Kenn Borek Air provided air support; UNAVCO provided geodetic instrument support. Hot water drilling activities, including repair and upgrade modifications of the WISSARD hot water drill system, for the SALSA project were supported by a subaward from the Ice Drilling Program of Dartmouth College (NSF-PLR 1327315) to the University of Nebraska-Lincoln. J. Lawrence assisted with manuscript preparation. Finally, we are grateful to C. Dean, the SALSA Project Manager, and R. Ricards, SALSA Project Coordinator at McMurdo Station, for their organizational skills, and B. Huber of Lamont-Doherty Earth Observatory for providing the SBE39 PT sensors and the Nortek Aquadopp current meter and assisting with interpretation of the data. B. Huber also provided helpful input on programing and calibrating the SBE19PlusV2 6112 CTD

Early diverging lineages within Cryptomycota and Chytridiomycota dominate the fungal communities in ice-covered lakes of the McMurdo Dry Valleys, Antarctica

Antarctic ice-covered lakes are exceptional sites for studying the ecology of aquatic fungi under conditions of minimal human disturbance. In this study, we explored the diversity and community composition of fungi in five permanently covered lake basins located in the Taylor and Miers Valleys of Antarctica. Based on analysis of the 18S rRNA sequences, we showed that fungal taxa represented between 0.93% and 60.32% of the eukaryotic sequences. Cryptomycota and Chytridiomycota dominated the fungal communities in all lakes; however, members of Ascomycota, Basidiomycota, Zygomycota, and Blastocladiomycota were also present. Of the 1313 fungal OTUs identified, the two most abundant, belonging to LKM11 and Chytridiaceae, comprised 74% of the sequences. Significant differences in the community structure were determined among lakes, water depths, habitat features (i.e., brackish vs. freshwaters), and nucleic acids (DNA vs. RNA), suggesting niche differentiation. Network analysis suggested the existence of strong relationships among specific fungal phylotypes as well as between fungi and other eukaryotes. This study sheds light on the biology and ecology of basal fungi in aquatic systems. To our knowledge, this is the first report showing the predominance of early diverging lineages of fungi in pristine limnetic ecosystems, particularly of the enigmatic phylum Cryptomycota.National Science Foundation/[PLR1439774]/NSF/Estados UnidosNational Science Foundation/[PLR1115245]/NSF/Estados UnidosNational Science Foundation/[PLR 1543537]/NSF/Estados UnidosNational Aeronautics and Space Administration/[NNH14ZDA001N-PSTAR]/NASA/Estados UnidosUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologí