On the presence of nonjet "higher harmonic" components in 2D angular correlations from high energy heavy ion collisions

It is conjectured that several higher harmonic flows $v_m$ may result from initial-state geometry fluctuations in \aa collisions coupled to a radially-expanding medium. But as with "elliptic flow" $v_2$ measurements, non-hydrodynamic mechanisms such as jet production may contribute to other higher azimuth multipoles $v_m$ as biases. Careful distinctions should be maintained between jet-related and nonjet (possibly hydrodynamic) contributions to $v_m$ (e.g., "nonflow" and "flow"). In this study we consider several questions: (a) To what extent do jet-like structures in two-dimensional (2D) angular correlations contribute to azimuth multipoles inferred from various $v_m$ methods? (b) If a multipole element is added to a 2D fit model is a nonzero amplitude indicative of a corresponding flow component? and (c) Can 2D correlations establish the necessity of nonjet contributions to some or all higher multipoles? Model fits to 2D angular correlations are used to establish the origins of azimuth multipoles inferred from 1D projections onto azimuth or from nongraphical numerical methods. We find that jet-like angular correlations, and specifically a 2D peak at the angular origin consistent with jet production, constitute the dominant contribution to inferred higher multipoles, and the data do not {\em require} higher multipoles in isolation from the jet-like 2D peak. Inference of "higher harmonic flows" results from identifying certain nominally jet-like structure as flow manifestations through unjustified application of 1D Fourier series analysis. Although the peak structure at the angular origin is strongly modified in more-central collisions some properties remain compatible with relevant pQCD theory expectations for jet production.Comment: 14 pages, 11 figure

Applicability of Monte Carlo Glauber models to relativistic heavy ion collision data

The accuracy of Monte Carlo Glauber model descriptions of minimum-bias multiplicity frequency distributions is evaluated using data from the Relativistic Heavy Ion Collider (RHIC) within the context of a sensitive, power-law representation introduced previously by Trainor and Prindle (TP). Uncertainties in the Glauber model input and in the mid-rapidity multiplicity frequency distribution data are reviewed and estimated using the TP centrality methodology. The resulting errors in model-dependent geometrical quantities used to characterize heavy ion collisions ({\em i.e.} impact parameter, number of nucleon participants $N_{part}$, number of binary interactions $N_{bin}$, and average number of binary collisions per incident participant nucleon $\nu$) are presented for minimum-bias Au-Au collisions at $\sqrt{s_{NN}}$ = 20, 62, 130 and 200 GeV and Cu-Cu collisions at $\sqrt{s_{NN}}$ = 62 and 200 GeV. Considerable improvement in the accuracy of collision geometry quantities is obtained compared to previous Monte Carlo Glauber model studies, confirming the TP conclusions. The present analysis provides a comprehensive list of the sources of uncertainty and the resulting errors in the above geometrical collision quantities as functions of centrality. The capability of energy deposition data from trigger detectors to enable further improvements in the accuracy of collision geometry quantities is also discussed.Comment: 27 pages, 4 figures, 11 table

TASTEX gamma spectrometer system for measuring isotopic and total plutonium concentrations in solutions

Described is a computer-based gamma ray spectrometer system using a germanium detector for rapid nondestructive measurement of isotopic and total plutonium concentrations in solutions at nuclear reprocessing plants. Isotopic concentrations have been measured with an accuracy of +-0.5%. Cell design, calibration techniques, and preliminary results are discussed. This system is being installed at the Tokai reprocessing plant in Japan

Half-life of /sup 239/Pu as determined by pulse-counting mass spectrometry

The half-life of /sup 239/Pu was measured by determining the ingrowth of /sup 235/U during a known time by isotope dilution mass spectrometry techniques

The Otterbein Miscellany - June 1982

https://digitalcommons.otterbein.edu/miscellany/1006/thumbnail.jp

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 bound to the inhibitor E5564 was solved, raising the possibility that novel TLR4 inhibitors that target the E5564-binding domain could be designed. We utilized a similarity search algorithm in conjunction with a limited screening approach of small molecule libraries to identify compounds that bind to the E5564 site and inhibit TLR4. Our lead compound, C34, is a 2-acetamidopyranoside (MW 389) with the formula C17H27NO9, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. Molecular docking of C34 to the hydrophobic internal pocket of the TLR4 co-receptor MD-2 demonstrated a tight fit, embedding the pyran ring deep inside the pocket. Strikingly, C34 inhibited LPS signaling ex-vivo in human ileum that was resected from infants with necrotizing enterocolitis. These findings identify C34 and the β-anomeric cyclohexyl analog C35 as novel leads for small molecule TLR4 inhibitors that have potential therapeutic benefit for TLR4-mediated inflammatory diseases. © 2013 Neal et al

Production of deuterium, tritium, and 3^3He in central Pb+Pb collisions at 20A, 30A, 40A, 80A, and 158A GeV at the CERN SPS

Production of $d$, $t$, and $^3$He nuclei in central Pb+Pb interactions was studied at five collision energies ($\sqrt{s_{NN}}=$ 6.3, 7.6, 8.8, 12.3, and 17.3 GeV) with the NA49 detector at the CERN SPS. Transverse momentum spectra, rapidity distributions, and particle ratios were measured. Yields are compared to predictions of statistical models. Phase-space distributions of light nuclei are discussed and compared to those of protons in the context of a coalescence approach. The coalescence parameters $B_2$ and $B_3$, as well as coalescence radii for $d$ and $^3$He were determined as a function of transverse mass at all energies.Comment: 22 pages, 29 figures, 8 tables, for submission to Phys. Rev.