Behaviour of Dimolyhdenum Tetraacetate in Aqueous Solutions of Hydrogen Halides. Synthesis and Crystal Structures of (pyH)2[Mo2(02CCH3)4Br2] and two Modifications of (pyH)2[Mo2(02CCH3 )4I2] (py =pyridine)

The axial diadducts (pyH)2[Mo2(02CCHa)4X2], (py =pyridine, X = Br, I) were isolated from solutions of dimolybdenum tetra- • acetate in HX 1 : 1 after addition of pyridinium halide. (pyH)2 [Mo2(02CCHa)4Br2] (A) crystallizes in the space group I4/m with a= 0.9746(2) nm, c = 1.3948(2) nm, V = 1.32484 nma and Z = 2. Two modifications of the iodide analog were isolated. Triclinic modification (B) crystallizes in the space group Pl with a= 1.0016(1) nm, b = 1.0092(2) nm, c = 1.6325(2) nm, a = 74.75(1)0 , fJ = 71.38(2) 0 , r = 61.12(2)0 , V = 1.35747 nm3 mid Z = 2; tetragonal modification (C) in the space group I4/mcm with a = 1.3086(1) nm, c = 1.4712(1) nm, V = 2.51933 nm3 and Z = 4. The Mo - X (X = Br, I) distances, found in anions [Mo2(02CCH3)4X2]2-, 287.9(3) pm in A, 326.2(1) pm and 329.9(1) pm in B, and 320.4(1) pm in C are quite long, indicating only weak axial coordination. Accordingly, the Mo - Mo distances 210.2(1) pm in A, 210.3(1) pm in B, and 210.2(1) pm in C are only slightly longer than the Mo - Mo distance of 209.3(1) pm found in Mo2(02CCHa)4

Behaviour of Dimolyhdenum Tetraacetate in Aqueous Solutions of Hydrogen Halides. Synthesis and Crystal Structures of (pyH)2[Mo2(02CCH3)4Br2] and two Modifications of (pyH)2[Mo2(02CCH3 )4I2] (py =pyridine)

The axial diadducts (pyH)2[Mo2(02CCHa)4X2], (py =pyridine, X = Br, I) were isolated from solutions of dimolybdenum tetra- • acetate in HX 1 : 1 after addition of pyridinium halide. (pyH)2 [Mo2(02CCHa)4Br2] (A) crystallizes in the space group I4/m with a= 0.9746(2) nm, c = 1.3948(2) nm, V = 1.32484 nma and Z = 2. Two modifications of the iodide analog were isolated. Triclinic modification (B) crystallizes in the space group Pl with a= 1.0016(1) nm, b = 1.0092(2) nm, c = 1.6325(2) nm, a = 74.75(1)0 , fJ = 71.38(2) 0 , r = 61.12(2)0 , V = 1.35747 nm3 mid Z = 2; tetragonal modification (C) in the space group I4/mcm with a = 1.3086(1) nm, c = 1.4712(1) nm, V = 2.51933 nm3 and Z = 4. The Mo - X (X = Br, I) distances, found in anions [Mo2(02CCH3)4X2]2-, 287.9(3) pm in A, 326.2(1) pm and 329.9(1) pm in B, and 320.4(1) pm in C are quite long, indicating only weak axial coordination. Accordingly, the Mo - Mo distances 210.2(1) pm in A, 210.3(1) pm in B, and 210.2(1) pm in C are only slightly longer than the Mo - Mo distance of 209.3(1) pm found in Mo2(02CCHa)4

The Chaotropically Synthesized Dimolybdenum(II,II) Compound

A non-classic approach in the synthesis and crystal growth within electrostricted water solutions of highly charged ionic species allowed us to obtain bright monocrystals of the zwitterionic tetracarboxylate compound Mo2(O2CC6H3(NH3)2)4Cl8 16H2O (1). The title compound tetrakis-(-3,5-diaminobenzoate)octachlorodimolybdenum(II,II)—aqua(1/16) (1) crystallizes in the P21/c monoclinic space group with a = 11.0825(13) Å, b = 23.983(3) Å, c = 10.935(6) Å, = 103.04(3)°, and Z = 2. Proton jumps between aromatic NH3+ and the neighbouring contacting groups H2O or Cl– of (1) increase the extent of donor (p–) interactions from equatorial oxygen atoms to the central dimolybdenum(II,II) core. Existence of unequivalent carboxylate ligands with different binding affinity around the Mo2 4+ dimer is indicated. The structure of the reference compound 3,5-diaminobenzoic acid—bis(hydrogen chloride)—hemihydrate 3,5-(H2N)2C6H3CO2H 2HCl 1/2H2O (2) was solved and compared with the structural data of (1). Triclinic needles of (2) crystallize in the P1 space group with a = 8.695(2) Å, b = 9.768(2) Å, c = 13.779(3) Å, α = 67.43(2), β = 68.69(2), γ = 72.66(2)° and Z = 4

The Chaotropically Synthesized Dimolybdenum(II,II) Compound

A non-classic approach in the synthesis and crystal growth within electrostricted water solutions of highly charged ionic species allowed us to obtain bright monocrystals of the zwitterionic tetracarboxylate compound Mo2(O2CC6H3(NH3)2)4Cl8 16H2O (1). The title compound tetrakis-(-3,5-diaminobenzoate)octachlorodimolybdenum(II,II)—aqua(1/16) (1) crystallizes in the P21/c monoclinic space group with a = 11.0825(13) Å, b = 23.983(3) Å, c = 10.935(6) Å, = 103.04(3)°, and Z = 2. Proton jumps between aromatic NH3+ and the neighbouring contacting groups H2O or Cl– of (1) increase the extent of donor (p–) interactions from equatorial oxygen atoms to the central dimolybdenum(II,II) core. Existence of unequivalent carboxylate ligands with different binding affinity around the Mo2 4+ dimer is indicated. The structure of the reference compound 3,5-diaminobenzoic acid—bis(hydrogen chloride)—hemihydrate 3,5-(H2N)2C6H3CO2H 2HCl 1/2H2O (2) was solved and compared with the structural data of (1). Triclinic needles of (2) crystallize in the P1 space group with a = 8.695(2) Å, b = 9.768(2) Å, c = 13.779(3) Å, α = 67.43(2), β = 68.69(2), γ = 72.66(2)° and Z = 4

Zdravljenje posledic obsevanja male medenice s hiperbaričnim kisikom

Radiation therapy is an important part of treatment of tumours of the pelvis minor. Late effects can develop months or years after treatment, and they occur in a severe form (RTOG grades 3 or 4) in 5-15% of irradiated patients. In the last few years, besides other invasive and non-invasive methods, radiotherapy-induced late complications have also been treated with hyperbaric oxygen therapy. Such treatment first proved successful in the treatment of osteonecrosis of the jaw, while in the last few years, the studies have confirmed that hyperbaric oxygen therapy is also effective in the treatment of post-radiation cystitis and proctitis. Hyperbaric oxygen therapy minimises the likelihood of complications, reduces the already developed symptoms and signs, and significantly improves the quality of life. In the last six years, only seven patients were treated with hyperbaric oxygen therapy at the Institute of Oncology Ljubljana for post-radiation injuries developed due to pelvic irradiation, although such treatment should be provided to 40-50 patients annually.Obsevanje predstavlja pomemben del zdravljenja tumorjev male medenice. Pozne posledice se lahko razvijejo od nekaj mesecev pa do več let po končanem zdravljenju in se vhudi obliki (3. ali 4. stopnje po lestvici RTOG) pojavijo pri 5 do 15 % obsevanih bolnikov. Poleg ostalih invazivnih in neinvazivnih metod se v zadnjih letih pri zdravljenju poznih zapletov obsevanja uporablja tudi zdravljenje s hiperbaričnim kisikom. Uspešnost tovrstnega zdravljenja je bila dokaza nanajprej za zdravljenje osteonekroze čeljustnice, v zadnjih letihpa so študije potrdile tudi uspešnost zdravljenja poobsevalnega cistitisa in proktitisa s hiperbaričnim kisikom. Zdravljenje s hiperbaričnim kisikom zmanjša verjetnost nastanka posledic, zmanjša že razvite simptome in znake ter pomembno izboljša kakovost življenja. V zadnjih šestih letih se je le 7 bolnikov Onkološkega inštituta Ljubljana zdravilo s hiperbaričnim kisikom zaradi poobsevalnih poškodb, ki so nastale zaradi obsevanja medenice, čeprav bi tovrstno zdravljenje letno potrebovalo 40 do 50 bolnikov. ; slv - slovensk

Synthesis, Characterization and Thermal Decomposition of [Cu(H2O)2(nia)2S04], nia = Nicotinamide

[Cu(H20)2(nia)2S04], nia = nicotinamide, was prepared by the reaction between aqueous solutions of CuS04 • 5H20 and nicotinamide, and was characterized by standard chemical and physical methods. Thermal behaviour of the sample in inert atmosphere proceeds in several steps. The dehydration of the sample (330—445 K) with 8.3% of mass loss (theoretical value 8.2%) is followed by a strong exothermal peak in DTA curve at 462 K, which is not accompanied by any significant mass change. Changes in electronic spectra and powder patterns of residues indicate a recrystallization process. This suggestion was confirmed by the EPR spectra of powder samples recorded in the temperature range from 295 K to 473 K. Changes of g values reflect modifications of the coordination sphere around copper(II) in the temperature range from 295 K to 423 K. In this temperature range, the symmetry type of the complex should have remained the same. However, above 423 K EPR spectra reflect major structural alternations. Significant changes of IR spectra in 900-1250 cm-1 region, where characteristic bands of S042- are present, indicate changes in the coordination mode of sulfate anion. All the observed results can be interpreted by slightly modified anation reaction in the solid state [Cu(H20)2(nia)2S04](s)—^->[Cu(nia)2S04](s) + 2 H20(g)

Treatment of the consequences of irradiation of pelvis minor with hyperbaric oxygen

Obsevanje predstavlja pomemben del zdravljenja tumorjev male medenice. Pozne posledice se lahko razvijejo od nekaj mesecev pa do več let po končanem zdravljenju in se vhudi obliki (3. ali 4. stopnje po lestvici RTOG) pojavijo pri 5 do 15 % obsevanih bolnikov. Poleg ostalih invazivnih in neinvazivnih metod se v zadnjih letih pri zdravljenju poznih zapletov obsevanja uporablja tudi zdravljenje s hiperbaričnim kisikom. Uspešnost tovrstnega zdravljenja je bila dokaza nanajprej za zdravljenje osteonekroze čeljustnice, v zadnjih letihpa so študije potrdile tudi uspešnost zdravljenja poobsevalnega cistitisa in proktitisa s hiperbaričnim kisikom. Zdravljenje s hiperbaričnim kisikom zmanjša verjetnost nastanka posledic, zmanjša že razvite simptome in znake ter pomembno izboljša kakovost življenja. V zadnjih šestih letih se je le 7 bolnikov Onkološkega inštituta Ljubljana zdravilo s hiperbaričnim kisikom zaradi poobsevalnih poškodb, ki so nastale zaradi obsevanja medenice, čeprav bi tovrstno zdravljenje letno potrebovalo 40 do 50 bolnikov.Radiation therapy is an important part of treatment of tumours of the pelvis minor. Late effects can develop months or years after treatment, and they occur in a severe form (RTOG grades 3 or 4) in 5-15% of irradiated patients. In the last few years, besides other invasive and non-invasive methods, radiotherapy-induced late complications have also been treated with hyperbaric oxygen therapy. Such treatment first proved successful in the treatment of osteonecrosis of the jaw, while in the last few years, the studies have confirmed that hyperbaric oxygen therapy is also effective in the treatment of post-radiation cystitis and proctitis. Hyperbaric oxygen therapy minimises the likelihood of complications, reduces the already developed symptoms and signs, and significantly improves the quality of life. In the last six years, only seven patients were treated with hyperbaric oxygen therapy at the Institute of Oncology Ljubljana for post-radiation injuries developed due to pelvic irradiation, although such treatment should be provided to 40-50 patients annuall

Two Types of Pyridine Ligands in Mononuclear and Dinuclear Copper(II) Carboxylates

Copper(II) acetate [Cu(OOCCH3)2(L1)2] (L1 = 2,6-diaminopyridine) (1), [Cu(OOCCH3)2(L2)2] (L2 = 2-amino-6-methylpyridine) (2) and benzoate compounds [Cu2(OOCC6H5)4(L1)2]·2CH3CN (3), [Cu2(OOCC6H5)4(L1)2] (4), [Cu2(OOCC6H5)4(L2)2] (5), [Cu(OOCC6H5)2(L2)2] (6), were synthesized and characterized. X-ray structure analysis revealed monomeric structure in 1 and 6. In 1, cis arrangement of the ligands was found, and trans in 6, in an elongated octahedral CuO4N2 chromophore. The basal plane in 1 and 6 is formed by one co-ordinated oxygen atom from both carboxylates (Cu–O 1.9560(12)–2.007(3) Å) and pyridine nitrogen atom from two pyridine ligands (Cu–N 2.013(3)–2.282(14) Å), forming a CuO2N2 plane, while the second carboxylate oxygen atoms are more distant (Cu–O 2.488(3)–2.7648(16) Å). The dinuclear paddle- wheel central core was found in 5 (Cu–O 1.942(6)–1.992(6) Å), with pyridine nitrogen atoms in the axial positions (Cu–N 2.283(7), 2.284(7) Å). All compounds were characterized by magnetic measurements, electronic and vibrational spectroscopy and tested for fungal growth retardation activity

Two Types of Pyridine Ligands in Mononuclear and Dinuclear Copper(II) Carboxylates

Copper(II) acetate [Cu(OOCCH3)2(L1)2] (L1 = 2,6-diaminopyridine) (1), [Cu(OOCCH3)2(L2)2] (L2 = 2-amino-6-methylpyridine) (2) and benzoate compounds [Cu2(OOCC6H5)4(L1)2]·2CH3CN (3), [Cu2(OOCC6H5)4(L1)2] (4), [Cu2(OOCC6H5)4(L2)2] (5), [Cu(OOCC6H5)2(L2)2] (6), were synthesized and characterized. X-ray structure analysis revealed monomeric structure in 1 and 6. In 1, cis arrangement of the ligands was found, and trans in 6, in an elongated octahedral CuO4N2 chromophore. The basal plane in 1 and 6 is formed by one co-ordinated oxygen atom from both carboxylates (Cu–O 1.9560(12)–2.007(3) Å) and pyridine nitrogen atom from two pyridine ligands (Cu–N 2.013(3)–2.282(14) Å), forming a CuO2N2 plane, while the second carboxylate oxygen atoms are more distant (Cu–O 2.488(3)–2.7648(16) Å). The dinuclear paddle- wheel central core was found in 5 (Cu–O 1.942(6)–1.992(6) Å), with pyridine nitrogen atoms in the axial positions (Cu–N 2.283(7), 2.284(7) Å). All compounds were characterized by magnetic measurements, electronic and vibrational spectroscopy and tested for fungal growth retardation activity