El proceso de aculturación de los Huarpes de Mendoza

Fil: Prieto de Herrera, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnica

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 10

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 10, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, que cuenta con el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. La gestión del conocimiento es un camino para consolidar una plataforma en las empresas públicas o privadas, entidades educativas, organizaciones no gubernamentales, ya sea generando políticas para todas las jerarquías o un modelo de gestión para la administración, donde es fundamental articular el conocimiento, los trabajadores, directivos, el espacio de trabajo, hacia la creación de ambientes propicios para el desarrollo integral de las instituciones

Early Meteorological Records from Latin-America and Caribbean during the 18th and 19th centuries, collection of data files

Early instrumental observations are an important tool to understand multidecadal climate variability or put in context specific extreme phenomena. This paper provides early instrumental data recovered in Latin-America and the Caribbean. Data have been retrieved from 20 countries (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) and they cover the 18th and 19th centuries. The main meteorological variables retrieved are air temperature, atmospheric pressure and precipitation but other variables, such as humidity, wind direction, or state of the sky have been retrieved when possible. In total, more than 300 000 early instrumental observations have been rescued (96% with daily resolution). Special effort has been done to document all the available metadata (instruments, observers, methodology of observation...) in order to allow further post processing. The compilation is far from being exhaustive but the data set will contribute to a better understanding of the climate variability in the region and to enlarge the overlapping period between instrumental data and natural and documentary proxies

Early Meteorological Records from Latin-America and Caribbean during the 18th and 19th centuries (link to zip file)

This dataset provides early instrumental data recovered in Latin-America and the Caribbean. Data have been retrieved from 20 countries (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) and they cover the 18th and 19th centuries. The main meteorological variables retrieved are air temperature, atmospheric pressure and precipitation but other variables, such as humidity, wind direction, or state of the sky have been retrieved when possible. In total, more than 300.000 early instrumental observations have been rescued. Each archive shows a headline with the following information: ID: 6 letters, the first three make reference to the country and the last three letters to the city/location of the observations. Country: Current name of the country where the observation were recorded. City: Current name of the city or location where the observation were recorded. Period: Time period covered by the series at monthly scale when possible. Resolution: Time resolution of the series. Observers: Name of the people that recorded the measurements. Location Observatory: Latitude and longitude of the observatory in WGS84, altitude when available. The name of the observatory or the street where it was is provided, when the location is exactly known. When the precise location is unknown a probable latitude and longitude is provided. Meteorological variables: Describe all the meteorological variables recorded, its units and the corresponding columns in the file. Data source: The complete reference of the documentary source in which the meteorological record was provided. Descriptive Name: A name of the archive that makes reference to the location and the period covered by the series. Other comments: All the metadata rescued about the observations or the observer. Also provides extreme or rare events recorded by the observer and any other information that could be useful to interpret the series. After the headline, the first columns give the temporal information of the record (year, season, month, day and hour) and the following columns show the measurements of each meteorological variable. Every column has a short descriptive title

La expresión corporal en educación física : propuesta curricular desde la administración educativa

Resumen basado en el de la publicaciónSe analiza la expresión corporal en la Educación Física y se presenta un estudio de caso de un Match de improvisación. La expresión corporal es el instrumento con el cual se producen las variadas formas del arte del movimiento. Es fundamental en el proceso de comunicación y éste debe ser interactivo y dinámico. Se analiza la expresión corporal como medio educativo para la formación integral del alumnado. En el estudio del caso, se muestra cómo se aplica al marco escolar y en qué puede ayudar.AndalucíaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

La orientación deportiva en el marco escolar : propuesta educativa para la educación física en secundaria

Resumen basado en el de la publicaciónSe ofrecen directrices de cómo llevar a cabo trabajos de orientación deportivo en los centros de Educación Secundaria y se contextualiza dentro del marco escolar y su currículum. La orientación es un deporte consistente en una carrera individual cronometrada donde los participantes usan un mapa esencial y una brújula para recorrer en el orden adecuado diferentes puntos de control. Se explican las diversas modalidades de orientación existentes: como actividad en la naturaleza, como deporte competitivo, como actividad de ocio al aire libre y como modo de mantenerse en forma. La orientación guarda relación con el currículo oficial de Educación Física y forma parte del bloque de contenidos de Actividades en el Medio Natural.AndalucíaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]