34 research outputs found
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Get PDFBACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients
The Power of God\u27s Word
Get PDFIf there is anything our generation of Christians needs to ponder and experience anew it is the power of God\u27s Word. For only when we seize and are seized by the Word of God do we know the exceeding greatness of His power toward us who believe (Eph.1:19). And only when our faith stands in God\u27s power do we discover what the Word of God really is (1 Cor. 2:5). Many theologians recognize the pressing necessity of speaking on this theme
The Vicarious Atonement in John Quenstedt
Get PDFThe last decades have witnessed some significant and provocative studies in the doctrine of the Atonement. Two of these studies particularly have stimulated interest by the way in which they have broken with the old Lutheran and Protestant treatment of the doctrine while attempting at the same time to be entirely Biblical in the approach and presentation of the doctrine. On the one hand, Gustaf Aulen classifies the post-Reformation teaching as only a slight and more logical modification of the doctrine of Anselm, a teaching dominated by the idea of satisfaction and the legal motif. In contrast to this, Aulen offers his well-known classic idea with its victory motif, and identifies this with Luther\u27s teaching
The Significance of Luther\u27s Term Pure Passive as Quoted in Article II of the Formula of Concord
Get PDFThe Lutheran doctrine of conversion, standing as it does between Calvinism and synergism, is always a difficult position to maintain and defend; for it is built on a paradox, a paradox of exclusive divine action and complete human participation. Faith is at the same time passive and active: passive in that man, blind and dead spiritually, in coming to faith only suffers God to work this change in his heart, active in that man himself believes and is in no way coerced in this nor divested of any of his faculties
Prolegomena According to Karl Barth
Get PDFIn a former article I pointed out by way of introduction that Karl Barth by his raking cognizance of both exegesis and church history ranks rightfully above most of his contemporaries as a dogmatician of stature. In the present article I shall try to examine Barth\u27s opinion on the subjects of theology and dogmatics more specifically. We shall find that Barth takes a position on the matter of prolegomena very close to that of the 16th- and 17th-cenrury Lutheran and Reformed teachers, that his position is in the main both Scriptural and sane. Here, although we shall perhaps discern nothing very outstanding in what he says and advocates, we shall find him to diverge very radically from most of his contemporaries. It will be up to us, after studying his views on prolegomena and dogmatics, to judge whether he himself has followed his own principles successfully
The Doctrine of Justification and Reconciliation in the Theology of Karl Barth
Get PDFThe doctrine of reconciliation is among the last subjects Barth has spoken on. This doctrine is presented in Vol. IV of his Church Dogmatics and embraces three parts. In Barth\u27s dogmatics reconciliation includes not only the doctrine of the atonement and justification but also the work and person of Christ and the application of salvation (conversion and sanctification)
