Design of the LHC Beam Dump Entrance Window

7 TeV proton beams from the LHC are ejected through a 600 m long beam dump transfer line vacuum chamber to a beam dump block. The dump block is contained within an inert gas-filled vessel to prevent a possible fire risk. The dump vessel and transfer line are separated by a 600 mm diameter window, which must withstand both the static pressure load and thermal shock from the passage of the LHC beam. In a previous paper [1] the functional requirements and conceptual design of this window were outlined. This paper describes the analysis leading to the final design of the window. The choice of materials is explained and tests performed on the prototype window are summarized

Beam Halo on the LHC TCDQ Diluter System and Thermal Load on the Downstream Superconducting Magnets

The moveable single-jawed graphite TCDQ diluter must be positioned very close to the circulating LHC beam in order to prevent damage to downstream components in the event of an unsynchronised beam abort. A two-jawed graphite TCS.IR6 collimator forms part of the TCDQ system. The requirement to place the jaws close to the beam means that the system can intercept a substantial beam halo load. Initial investigations indicated a worryingly high heat load on the Q4 coils. This paper presents the updated load cases, shielding and simulation geometry, and the results of simulations of the energy deposition in the TCDQ system and in the downstream superconducting Q4 magnet. The implications for the operation of the LHC are discussed

Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple β-defensins in gingival keratinocytes

BACKGROUND: Human β-defensins (hBDs) are antimicrobial peptides with a role in innate immune defense. Our laboratory previously showed that a single nucleotide polymorphism (SNP) in the 5' untranslated region of the hBD1 gene (DEFB1), denoted -44 (rs1800972), is correlated with protection from oral Candida. Because this SNP alters the putative mRNA structure, we hypothesized that it alters hBD1 expression. METHODS: Transfection of reporter constructs and evaluation of antimicrobial activity and mRNA expression levels in keratinocytes from multiple donors were used to evaluate the effect of this SNP on constitutive and induced levels of expression. RESULTS: Transfection of CAT reporter constructs containing the 5' untranslated region showed that the -44 G allele yielded a 2-fold increase in CAT protein compared to other common haplotypes suggesting a cis effect on transcription or translation. The constitutive hBD1 mRNA level in human oral keratinocytes was significantly greater in cells from donors with the -44 GG genotype compared to those with the common CC genotype. Surprisingly, the hBD3 mRNA level as well as antimicrobial activity of keratinocyte extracts also correlated with the -44 G allele. Induced levels of hBD1, hBD2, and hBD3 mRNA were evaluated in keratinocytes challenged with Toll-like receptor 2 and 4 ligands, interleukin-1β, TNFα, and interferon-γ (IFNγ). In contrast to constitutive expression levels, IFNγ-induced keratinocyte hBD1 and hBD3 mRNA expression was significantly greater in cells with the common CC genotype, but there was no clear correlation of genotype with hBD2 expression. CONCLUSION: The DEFB1 -44 G allele is associated with an increase in overall constitutive antimicrobial activity and expression of hBD1 and hBD3 in a manner that is consistent with protection from candidiasis, while the more common C allele is associated with IFNγ inducibility of these β-defensins and is likely to be more protective in conditions that enhance IFNγ expression such as chronic periodontitis. These results suggest a complex relationship between genetics and defensin expression that may influence periodontal health and innate immune responses

The Search for Higher TcT_c in Houston

It is a great pleasure to be invited to join the chorus on this auspicious occasion to celebrate Professor K. Alex Mueller's 90th birthday by Professors Annette Bussman-Holder, Hugo Keller, and Antonio Bianconi. As a student in high temperature superconductivity, I am forever grateful to Professor Alex Mueller and Dr. Georg Bednorz "for their important breakthrough in the discovery of superconductivity in the ceramic materials" in 1986 as described in the citation of their 1987 Nobel Prize in Physics. It is this breakthrough discovery that has ushered in the explosion of research activities in high temperature superconductivity (HTS) and has provided immense excitement in HTS science and technology in the ensuing decades till now. Alex has not been resting on his laurels and has continued to search for the origin of the unusual high temperature superconductivity in cuprates.Comment: Dedicated to Alex Mueller, whose "important breakthrough in the discovery of superconductivity in ceramic materials" in 1986 has changed the world of superconductivit

Implications of the isotope effects on the magnetization, magnetic torque and susceptibility

We analyze the magnetization, magnetic torque and susceptibility data of La2-xSrxCu(16,18)O4 and YBa2(63,65)CuO7-x near Tc in terms of the universal 3D-XY scaling relations. It is shown that the isotope effect on Tc mirrors that on the anisotropy. Invoking the generic behavior of the anisotropy the doping dependence of the isotope effects on the critical properties, including Tc, correlation lengths and magnetic penetration depths are traced back to a change of the mobile carrier concentration.Comment: 5 pages, 3 figure

Coherent quasiparticle weight and its connection to high-T_c superconductivity from angle-resolved photoemission

In conventional superconductors, the pairing energy gap (\Delta) and superconducting phase coherence go hand-in-hand. As the temperature is lowered, both the energy gap and phase coherence appear at the transition temperature T_c. In contrast, in underdoped high-T_c superconductors (HTSCs), a pseudogap appears at a much higher temperature T^*, smoothly evolving into the superconducting gap at T_c. Phase coherence on the other hand is only established at T_c, signaled by the appearance of a sharp quasiparticle (QP) peak in the excitation spectrum. Another important difference between the two types of superconductors is in the ratio of 2\Delta / T_c=R. In BCS theory, R~3.5, is constant. In the HTSCs this ratio varies widely, continuing to increase in the underdoped region, where the gap increases while T_c decreases. Here we report that in HTSCs it is the ratio z_A\Delta_m/T_c which is approximately constant, where \Delta_m is the maximum value of the d-wave gap, and z_A is the weight of the coherent excitations in the spectral function. This is highly unusual, since in nearly all phase transitions, T_c is determined by an energy scale alone. We further show that in the low-temperature limit, z_{\it A} increases monotonically with increasing doping x. The growth is linear, i.e. z_A(x)\propto x, in the underdoped to optimally doped regimes, and slows down in overdoped samples. The reduction of z_A with increasing temperature resembles that of the c-axis superfluid density.Comment: 11 pages, 5 figures, revised versio

Thermopower in the strongly overdoped region of single-layer Bi2Sr2CuO6+d superconductor

The evolution of the thermoelectric power S(T) with doping, p, of single-layer Bi2Sr2CuO6+d ceramics in the strongly overdoped region is studied in detail. Analysis in term of drag and diffusion contributions indicates a departure of the diffusion from the T-linear metallic behavior. This effect is increased in the strongly overdoped range (p~0.2-0.28) and should reflect the proximity of some topological change.Comment: 4 pages, 4 figure

Anomalous superconducting state gap size versus Tc behavior in underdoped Bi_2Sr_2Ca_1-xDy_xCu_2O_8+d

We report angle-resolved photoemission spectroscopy measurements of the excitation gap in underdoped superconducting thin films of Bi_2Sr_2Ca_{1-x}Dy_xCu_2O_{8+d}. As Tc is reduced by a factor of 2 by underdoping, the superconducting state gap \Delta does not fall proportionally, but instead stays constant or increases slightly, in violation of the BCS mean-field theory result. The different doping dependences of \Delta and kT_c indicate that they represent different energy scales. The measurements also show that \Delta is highly anisotropic and consistent with a d_{x^2-y^2} order parameter, as in previous studies of samples with higher dopings. However, in these underdoped samples, the anisotropic gap persists well above T_c. The existence of a normal state gap is related to the failure of \Delta to scale with T_c in theoretical models that predict pairing without phase coherence above T_c.Comment: 10 pages, 4 postscript figures, revtex forma

Anomalous electronic susceptibility in Bi2Sr2CuO6+d and comparison with other overdoped cuprates

We report magnetic susceptibility performed on overdoped Bi2Sr2CuO6+d powders as a function of oxygen doping d and temperature T. The decrease of the spin susceptibility with increasing T is confirmed. At sufficient high temperature, the spin susceptibility Chi_s presents an unusual linear temperature dependence Chi_s ~ Chi_s0 -Chi_1 T. Moreover, a linear correlation between Chi_1 and Chi_s0 for increasing hole concentration is displayed. A temperature Tchi, independent of hole doping characterizes this scaling. Comparison with other cuprates of the literature(LSCO, Tl-2201 and Bi-2212), over the same overdoped range, shows similarities with above results. These non conventional metal features will be discussed in terms of a singular narrow-band structure.Comment: 16 pages, 4 figure

Thermal Conductivity across the Phase Diagram of Cuprates: Low-Energy Quasiparticles and Doping Dependence of the Superconducting Gap

Heat transport in the cuprate superconductors YBa$_2$Cu$_3$O$_{y}$ and La$_{2-x}$Sr$_x$CuO$_4$ was measured at low temperatures as a function of doping. A residual linear term kappa_{0}/T is observed throughout the superconducting region and it decreases steadily as the Mott insulator is approached from the overdoped regime. The low-energy quasiparticle gap extracted from kappa_{0}/T is seen to scale closely with the pseudogap. The ubiquitous presence of nodes and the tracking of the pseudogap shows that the overall gap remains of the pure d-wave form throughout the phase diagram, which excludes the possibility of a complex component (ix) appearing at a putative quantum phase transition and argues against a non-superconducting origin to the pseudogap. A comparison with superfluid density measurements reveals that the quasiparticle effective charge is weakly dependent on doping and close to unity.Comment: 12 pages, 9 figure