Search for pair and single production of new heavy quarks that decay to a Z boson and a third-generation quark in pp collisions at root s=8 TeV with the ATLAS detector

A search is presented for the production of new heavy quarks that decay to a Z boson and a third-generation Standard Model quark. In the case of a new charge +2/3 quark (T), the decay targeted is T - GT Zt, while the decay targeted for a new charge -1/3 quark (B) is B - GT Zb. The search is performed with a dataset corresponding to 20.3 fb(-1) of p p collisions at root s = 8TeV recorded in 2012 with the ATLAS detector at the CERN Large Hadron Collider. Selected events contain a high transverse momentum Z boson candidate reconstructed from a pair of oppositely charged same-flavor leptons (electrons or muons), and are analyzed in two channels defined by the absence or presence of a third lepton. Hadronic jets, in particular those with properties consistent with the decay of a b-hadron, are also required to be present in selected events. Different requirements are made on the jet activity in the event in order to enhance the sensitivity to either heavy quark pair production mediated by the strong interaction, or single production mediated by the electroweak interaction. No significant excess of events above the Standard Model expectation is observed, and lower limits are derived on the mass of vector-like T and B quarks under various branching ratio hypotheses, as well as upper limits on the magnitude of electroweak coupling parameters

Search for the lepton flavor violating decay Z - GT e mu in pp collisions at root s=8 TeV with the ATLAS detector

The ATLAS detector at the Large Hadron Collider is used to search for the lepton flavor violating process Z - GT e mu in pp collisions using 20.3 fb(-1) of data collected at root s = 8 TeV. An enhancement in the e mu invariant mass spectrum is searched for at the Z-boson mass. The number of Z bosons produced in the data sample is estimated using events of similar topology, Z - GT ee and mu mu, significantly reducing the systematic uncertainty in the measurement. There is no evidence of an enhancement at the Z-boson mass, resulting in an upper limit on the branching fraction, B(Z - GT e mu) LT 7.5 x 10(-7) at the 95% confidence level

Force-Velocity Profiles of Elite Athletes Tested on a Cycle Ergometer

The present study explored the sensitivity of the force-velocity (F-V) modelling approach obtained from maximal sprints on a leg cycle ergometer to detect selective changes of the mechanical capacities of the lower body muscles associated with high-level training. Specifically, we assumed that the F-V relationship parameters, such as maximum force (F0 ), velocity (V0 ), power (PM) and slope, would differ among individuals of different high-level training backgrounds. In total, 111 elite athletes divided into four groups (Combat sports, Athletic sprints, Team sports and Physically active) performed maximal sprints on a leg cycle ergometer loaded with 7%, 9%, and 11% of body weight. The findings obtained suggest an exceptionably strong and linear F-V relationship in most of the participants (r > 0.95), while higher PM have been found in all groups of athletes compared to the Physically active group (p < 0.05). In addition, sport-specific F-V profiles have been observed in athletes that belong to distinctively different sports (i.e. higher F0 and forceoriented slope for strength-trained Combat sports and higher V0 for speed-trained Athletic sprints). To our knowledge, this is one of the rare studies that evaluate the F-V profiles with such a large sample of elite athletes obtained from commonly used task such as maximal sprints on a leg cycle ergometer. The results obtained support a high sensitivity of the F-V modelling approach to distinguish among elite athletes with different training histories

Prevalence and early detection of abdominal aortic aneurysm in pseudoexfoliation syndrome and pseudoexfoliation glaucoma

PURPOSE: The goals of this study were to demonstrate the frequency of infrarenal abdominal aortic aneurysm (AAA) in patients with pseudoexfoliation (PEX) syndrome (PEXS) and PEX glaucoma (PEXG), and to determine whether limited screening for AAA in specific subgroups of patients with PEX is reasonable and justifiable. MATERIALS AND METHODS: This prospective study comprised 60 patients with PEXS and 60 with PEXG (examined group), and 60 patients with primary open-angle glaucoma (POAG) and 60 with cataract (control group). Clinical ophthalmic examination included slit-lamp biomicroscopy of the anterior segment and direct slit-lamp gonioscopy (using a Goldmann three-mirror lens) of the anterior chamber angle. All patients underwent routine Color Doppler duplex ultrasonography of the infrarenal aorta and iliac arteries. RESULTS: There was a statistically significant difference (p < 0.05) between the PEXG group and control group vis-a-vis presence of AAA, which occurred more frequently in patients with greater amounts of angle pigmentation (p < 0.05). Univariate logistic regression analysis indicated statistically significant associations between AAA and PEX (p < 0.01), angle pigmentation (p < 0.05), gender (p < 0.01), diabetes mellitus (DM) (p < 0.05), and arterial hypertension (AHT) (p < 0.01). Multivariate regression analysis, adjusted to gender and age, showed that the most important clinical parameters related to AAA in patients with PEXS and PEXG are gender, presence of PEX, DM, and AHT (p < 0.05). CONCLUSION: The frequency of AAA is significantly higher in patients with PEXS and PEXG than in patients with POAG or cataract. Restricted screening for AAA in male PEXS patients, who also have elevated degrees of angle pigmentation, arterial hypertension, and DM, is clinically warranted

Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury

Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate the effects of the treatment with vitamin B (B1, B2, B3, B5, B6, and B12) complex on the interaction between macrophages and SCs during the recovery period after PNI. Transection of the motor branch of the femoral nerve followed by reconstruction by termino-terminal anastomosis was used as an experimental model. Isolated nerves from the sham (S), operated (O), and operated groups treated with the B vitamins (OT group) were used for immunofluorescence analysis. The obtained data indicated that PNI modulates interactions between macrophages and SCs in a time-dependent manner. The treatment with B vitamins complex promoted the M1-to M2-macrophage polarization and accelerated the transition from the non-myelin to myelin-forming SCs, an indicative of SCs maturation. The effect of B vitamins complex on both cell types was accompanied with an increase in macrophage/SC interactions, all of which correlated with the regeneration of the injured nerve. Clearly, the capacity of B vitamins to modulate macrophages-SCs interaction may be promising for the treatment of PNI