Učinak ricinoleične kiseline iz ricinusova ulja na proizvodna svojstva i hemato-biokemijski profil krava pasmine Kankrej u laktaciji

The aim of the present study was to evaluate the effects of dietary ricinoleic acid from castor oil on the milk yield, composition, fatty acid profile and haemato-biochemical profile in lactating Kankrej cows. Twenty lactating Kankrej cows were assigned to the following groups: control (CON), basal diet without any additive and treatment (RAS), basal diet with 2 g/animal/day of ricinoleic acid from castor oil. Dietary ricinoleic acid had no (P>0.05) effect on dry matter intake and feed efficiency. Milk yield (milk, 4% fat corrected milk and energy corrected milk) were not affected (P>0.05) by the feeding of ricinoleic acid. The milk composition showed no significant differences between the groups. A significantly (P0.05) in haemato-biochemical profile between the CON and RAS groups. It was concluded that supplementation of 2 g/animal/day ricinoleic acid from castor oil had no effect on milk yield, milk composition and haemato-biochemical profile. However, it increased the milk fat percentages of unsaturated fatty acids and polyunsaturated fatty acids, and decreased milk saturated fatty acids, without any adverse effect on the health status of the cows.Cilj istraživanja bio je procijeniti učinak ricinoleične kiseline iz ricinusova ulja na prinos mlijeka, kemijski sastav mlijeka, profil masnih kiselina u mlijeku te na hemato-biokemijski profil krava pasmine Kankrej u laktaciji. Ukupno 20 krava u laktaciji podijeljeno je u: kontrolnu skupinu (CON), skupinu koja je dobivala osnovnu hranu, bez dodataka i pokusnu skupinu (RAS), koja je dobivala osnovnu hranu i 2 g po životinji dnevno ricinoleične kiseline iz ricinusova ulja. Ricinoleična kiselina nije imala učinka (P>0,05) na unos suhe tvari i iskorištavanje hrane. Dodatak ricinoleične kiseline nije utjecao (P>0,05) na prinos mlijeka (mlijeko, obogaćeno mlijeko s 4 % masnoće i energijski obogaćeno mlijeko). Sastav mlijeka nije pokazao znakovite razlike među skupinama. Uočen je znakovito veći postotak C4:0, C6:0 i C8:0 u mlijeku u skupini RAS (P0,05) u hemato-biokemijskom profilu skupina CON i RAS. Zaključeno je da dodatak 2 g ricinoleične kiseline po životinji dnevno ne utječe na prinos i sastav mlijeka te hemato- biokemijski profil, međutim povećava postotak mliječne masti, nezasićenih masnih kiselina i višestruko nezasićenih masnih kiselina, a smanjuje postotak zasićenih masnih kiselina bez posljedica za zdravlje krava

Formulation development and evaluation of mouth dissolving film of domperidone

The present investigation was undertaken with the objective of formulating mouth dissolving film(s) of the antiemetic drug Domperidone to enhance the convenience and compliance by the elderly and pediatric patients. Domperidone is a drug of choice in case of nausea and vomiting produced by chemotherapy, migraine headaches, food poisoning and viral infections. It causes dopamine (D2 and D3) receptor blockage both at the chemoreceptor trigger zone and at the gastric level. It shows high first pass metabolism which results in poor bioavailability (10-15%). In view of high first pass metabolism and short plasma half-life it is an ideal candidate for rapid release drug delivery system. The solid dispersions of Domperidone were prepared with the use β-cyclodextrin in various ratios (1:1, 1:2, 1:3) and solubility study was performed to determine the ratio in which solubility of Domperidone was highest (1:3). The selected solid dispersions were then utilized for the preparation of film by solvent casting method utilizing HPMC E15 as a film forming agent and PEG-400 as plasticizer. Five formulae were prepared and were evaluated for their in vitro dissolution characteristics, in vitro disintegration time, and their physico-mechanical properties. The promising film (F1) showed the greatest drug dissolution (more than 75% within 15 min), satisfactory in vitro disintegration time (45 sec) and physico-mechanical properties that are suitable for mouth dissolving films