Free convection heat and mass transfer of a nanofluid past a horizontal cylinder embedded in a non-Darcy porous medium

In the present paper, we analyzed the laminar boundary layer flow and heat transfer from a horizontal cylinder in a nanofluid-saturated non-Darcy porous medium in the presence of thermal radiation. This is the first paper presenting non-similar solutions for such a regime.The boundary layer conservation equations,which are parabolic in nature,are normalized into non-similar form and then solved computationally with an efficient, implicit, stable Keller-box finite difference scheme. Non-Darcy effects are simulated via a second-order Forchheimer drag force term in the momentum boundary layer equation. The model used for the nanofluid incorporates the effects of Brownian motion, buoyancy ratio, and thermophoresis. A non-similarity solution is presented that depends on the Brownian motion number (Nb), buoyancy ratio (Nr), thermophoresis number (Nt), Forchheimer parameter (Λ), and radiation parameter (F). Velocity is reduced with increasing Forchheimer parameter, whereas temperature and nanoparticle concentration are both enhanced.The model finds applications in energy systems and thermal enhancement of industrial flow processe

Numerical study of viscoelastic micropolar heat transfer from a vertical cone for thermal polymer coating

A mathematical model is developed to study laminar, nonlinear, non-isothermal, steady-state free convection boundary layer flow and heat transfer of a micropolar viscoelastic fluid from a vertical isothermal cone. The Eringen model and Jeffery’s viscoelastic model are combined to simulate the non-Newtonian characteristics of polymers, which constitutes a novelty of the present work. The transformed conservation equations for linear momentum, angular momentum and energy are solved numerically under physically viable boundary conditions using a finite difference scheme (Keller Box method). The effects of Deborah number (De), Eringen vortex viscosity parameter (R), ratio of relaxation to retardation times (λ), micro-inertia density parameter (B), Prandtl number (Pr) and dimensionless stream wise coordinate (ξ) on velocity, surface temperature and angular velocity in the boundary layer regime are evaluated. The computations show that with greater ratio of retardation to relaxation times, the linear and angular velocity are enhanced whereas temperature (and also thermal boundary layer thickness) is reduced. Greater values of the Eringen parameter decelerate both the linear velocity and micro-rotation values and enhance temperatures. Increasing Deborah number decelerates the linear flow and Nusselt number whereas it increases temperatures and boosts micro-rotation magnitudes. The study is relevant to non-Newtonian polymeric thermal coating processes

Nanozyme-amplified lateral flow immunoassay for molecular signature detection of cardiovascular diseases

Point-of-care (PoC) devices offer the opportunity to decentralize the analysis of biomarkers in biological fluids thus providing patients with more personalized medicine. The golden standard of PoC platforms are lateral flow assays since they are low cost, quick to perform and user-friendly [1]. Here we show the use of a nanozyme-mediated signal readout on a multiplexed PoC lateral flow immunoassay for the diagnosis of cardiovascular diseases. Our aim has been to expand the application of this ultrasensitive detection method towards the development of a multiplexed PoC assay for cardiovascular-related biomarkers to support triage of myocardial injury

Measuring Height Change Around the Periphery of the Greenland Ice Sheet With Radar Altimetry

This work is licensed under a Creative Commons Attribution 4.0 International License.Ice loss measurements around the periphery of the Greenland Ice Sheet can provide key information on the response to climate change. Here we use the excellent spatial and temporal coverage provided by the European Space Agency (ESA) CryoSat satellite, together with NASA airborne Operation IceBridge and automatic weather station data, to study the influence of changing conditions on the bias between the height estimated by the satellite radar altimeter and the ice sheet surface. Surface and near-surface conditions on the ice sheet periphery change with season and geographic position in a way that affects the returned altimeter waveform and can therefore affect the estimate of the surface height derived from the waveform. Notwithstanding the possibility of a varying bias between the derived and real surface, for the lower accumulation regions in the western and northern ice sheet periphery (<∼1 m snow accumulation yearly) we show that the CryoSat altimeter can measure height change throughout the year, including that associated with ice dynamics, summer melt and winter accumulation. Further, over the 9-year CryoSat lifetime it is also possible to relate height change to change in speed of large outlet glaciers, for example, there is significant height loss upstream of two branches of the Upernavik glacier in NW Greenland that increased in speed during this time, but much less height loss over a third branch that slowed in the same time period. In contrast to the west and north, winter snow accumulation in the south-east periphery can be 2–3 m and the average altimeter height for this area can decrease by up to 2 m during the fall and winter when the change in the surface elevation is much smaller. We show that vertical downward movement of the dense layer from the last summer melt, coupled with overlying dry snow, is responsible for the anomalous altimeter height change. However, it is still possible to estimate year-to-year height change measurements in this area by using data from the late-summer to early fall when surface returns dominate the altimeter signal

Numerical simulation and energy flux vector visualization of radiative-convection heat transfer in a porous triangular enclosure

A detailed theoretical examination laminar natural convection heat flow in a triangular porous cavity with significant radiative heat transfer and porosity variation is presented. Twodimensional laminar incompressible flow is considered with the left slant and right walls are low and high temperature respectively, and the remaining (top) wall prescribed as adiabatic. The Darcy-Brinkman isotropic model is utilized, and the coupled governing equations are solved by a numerical method utilizing finite differences. Visualization of isotherms and streamlines is achieved with the method of Energy Flux Vectors (EFVs). The impacts of the different model parameters (Rayleigh number Ra, Darcy number-Da, porosity-E and radiation parameter-Rd) on the thermo fluid characteristics are studied in detail. The computations show that convective heat transfer is enhanced with greater Darcy parameter (permeability) which also leads to intensification in the density of energy flux vector patterns. The flow is accelerated with increasing buoyancy effect (Rayleigh number) and temperatures are also increased with greater radiative flux. Average Nusselt number is decreased with higher porosity. The simulations are relevant to hybrid porous media solar collectors

Designing an information system for updating land records in Bangladesh: action design ethnographic research (ADER)

Open Access. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Information Systems (IS) has developed through adapting, generating and applying diverse methodologies, methods, and techniques from reference disciplines. Further, Action Design Research (ADR) has recently developed as a broad research method that focuses on designing and redesigning IT and IS in organizational contexts. This paper reflects on applying ADR in a complex organizational context in a developing country. It shows that ADR requires additional lens for designing IS in such a complex organizational context. Through conducting ADR, it is seen that an ethnographic framework has potential complementarities for understanding complex contexts thereby enhancing the ADR processes. This paper argues that conducting ADR with an ethnographic approach enhances design of IS and organizational contexts. Finally, this paper aims presents a broader methodological framework, Action Design Ethnographic Research (ADER), for designing artefacts as well as IS. This is illustrated through the case of a land records updating service in Bangladesh

Open Problems on Central Simple Algebras

We provide a survey of past research and a list of open problems regarding central simple algebras and the Brauer group over a field, intended both for experts and for beginners.Comment: v2 has some small revisions to the text. Some items are re-numbered, compared to v

Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial

<p>Abstract</p> <p>Background</p> <p>Pneumonia is a leading cause of children's deaths in developing countries and hinders achievement of the fourth Millennium Development Goal. This goal aims to reduce the under-five mortality rate, by two thirds, between 1990 and 2015.</p> <p>Few studies have examined the impact of zinc adjunct therapy on the outcome of childhood pneumonia. We determined the effect of zinc as adjunct therapy on time to normalization of respiratory rate, temperature and oxygen saturation. We also studied the effect of zinc adjunct therapy on case fatality of severe childhood pneumonia (as a secondary outcome) in Mulago Hospital, Uganda.</p> <p>Methods</p> <p>In this double blind, randomized, placebo-controlled clinical trial, 352 children aged 6 to 59 months, with severe pneumonia were randomized to zinc (20 mg for children ≥12 months, and 10 mg for those < 12 months) or a placebo once daily for seven days, in addition to standard antibiotics for severe pneumonia. Children were assessed every six hours. Oxygen saturation was normal if it was above 92% (breathing room air) for more than 15 minutes. The respiratory rate was normal if it was consistently (more than 24 hours) below 50 breaths per minute in infants and 40 breaths per minute in children above 12 months of age. Temperature was normal if consistently below 37.5°C. The difference in case fatality was expressed by the risk ratio between the two groups.</p> <p>Results</p> <p>Time to normalization of the respiratory rate, temperature and oxygen saturation was not significantly different between the two arms.</p> <p>Case fatality was 7/176 (4.0%) in the zinc group and 21/176 (11.9%) in the placebo group: Relative Risk 0.33 (95% CI 0.15 to 0.76). Relative Risk Reduction was 0.67 (95% CI 0.24 to 0.85), while the number needed to treat was 13. Among HIV infected children, case fatality was higher in the placebo (7/27) than in the zinc (0/28) group; RR 0.1 (95% CI 0.0, 1.0).</p> <p>Among 127 HIV uninfected children receiving the placebo, case fatality was 7/127 (5.5%); versus 5/129 (3.9%) among HIV uninfected group receiving zinc: RR 0.7 (95% CI 0.2, 2.2). The excess risk of death attributable to the placebo arm (Absolute Risk Reduction or ARR) was 8/100 (95% CI: 2/100, 14/100) children. This excess risk was substantially greater among HIV positive children than in HIV negative children (ARR: 26 (95% CI: 9, 42) per 100 versus 2 (95% CI: -4, 7) per 100); <it>P</it>-value for homogeneity of risk differences = 0.006.</p> <p>Conclusion</p> <p>Zinc adjunct therapy for severe pneumonia had no significant effect on time to normalization of the respiratory rate, temperature and oxygen saturation. However, zinc supplementation in these children significantly decreased case fatality.</p> <p>The difference in case fatality attributable to the protective effect of zinc therapy was greater among HIV infected than HIV uninfected children. Given these results, zinc could be considered for use as adjunct therapy for severe pneumonia, especially among Highly Active Antiretroviral Therapy</p> <p>naïve HIV infected children in our environment.</p> <p>Clinical trials registration number</p> <p>clinicaltrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT00373100">NCT00373100</a></p

X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury

This paper describes the results of the application of X-ray fluorescence microscopy to the qualitative, topographic and quantitative elemental analysis of nervous tissue from rats with neocortical brain injury. The tissue samples were analyzed with a 15 μm beam defined by the size of the polycapillary focus. Raster scanning of the samples generated 2D cartographies, revealing the distributions of elements such as P, S, Cl, K, Ca, Fe, Cu, and Zn. Special emphasis was placed on the analysis of the areas neighboring the lesion site and the hippocampal formation tissue. The results obtained for rats with mechanical brain injuries were compared with those recorded for controls and animals with pilocarpine-induced seizures. There were no significant differences in the elemental compositions of gray and white matter between injured and uninjured brain hemispheres. A higher level of Ca was observed in the gray matter of both of the hemispheres in brains with neocortical injuries. A similar relation was noticed for Fe in the white matter. A comparative study of hippocampal formation tissue showed a statistically significant decrease in the mass per unit area of P in the dentate gyrus (DG) and the hilus (H) of DG for animals with brain lesions in comparison with the control group. Analogous relations were found for Cu in the DG and Zn in sector 3 of Ammon’s horn (CA3) and the DG. It is important to note that identical changes in the same areas were observed for animals with pilocarpine-induced seizures in our previous study