2 research outputs found
Grupos sanguĂneos e lĂşpus eritematoso crĂ´nico discoide Blood groups and discoid lupus erythematosus
FUNDAMENTOS: LesĂŁo discoide Ă© a manifestação cutânea mais comum do lĂşpus eritematoso, e formas cutâneas crĂ´nicas apresentam caracterĂsticas imunolĂłgicas prĂłprias, direcionadas ao polo Th1. Diversas doenças possuem associação com grupos sanguĂneos, o que nĂŁo foi ainda estudado no lĂşpus discoide. OBJETIVO: Investigar a associação entre tipos sanguĂneos (ABO e Rh) e lĂşpus eritematoso discoide. MÉTODOS: Estudo prospectivo tipo transversal envolvendo tipagem sanguĂnea ABO e Rh, inquĂ©rito de dados clĂnicos e dosagem de FAN e C4 de portadores de lĂşpus discoide sem critĂ©rios de doença sistĂŞmica, atendidos em hospital universitário. RESULTADOS: Foram incluĂdos no estudo 69 pacientes, sendo 71,0% do sexo feminino (p 1:160, em 31,9%; e nĂveis baixos de C4, em 8,7%. NĂŁo houve diferença significativa entre as frequĂŞncias dos grupos sanguĂneos dos pacientes e da população local; entretanto, o grupo A foi associado Ă s formas disseminadas da doença (OR 4,1 e p < 0,05). CONCLUSĂ•ES: Grupos sanguĂneos de pacientes com lĂşpus discoide apresentam frequĂŞncia semelhante Ă da população; porĂ©m, formas clĂnicas disseminadas foram mais prevalentes entre portadores do grupo A.<br>Background: Discoid lesion is the commonest cutaneous finding in lupus erythematosus and chronic types have their own immunological features, with Th1 inflammation profile. Although many diseases have association with blood-group systems, this fact was not enlightened in discoid lupus erythematosus. Objective: To investigate the association between blood groups (ABO and Rh) and discoid lupus erythematosus. Methods: A prospective cross-sectional study assessing clinical information, blood group systems (ABO and Rh), FAN and C4 serum levels from discoid lupus patients without characteristics of systemic disease, was carried out at a clinic from a Brazilian university hospital. Results: Sixty-nine patients were enrolled in the study, 71.0% were females (p1:160 in 31.9%, and low levels of C4 in 8.7%. There was no significant difference between the frequency of blood groups from discoid lupus patients and local population, however, blood group A was associated to disseminate forms of the disease (OR 4.1 and p < 0.05). Conclusions: Discoid lupus erythematosus patients with ABO and Rh blood groups exhibit similar frequencies as in the general population; nevertheless, disseminate clinical forms were more prevalent among group A patients